Contrasting impacts of fertilization on topsoil and subsoil greenhouse gas fluxes in a thinned Chinese fir plantation.

Globally, forest soils are considered as important sources and sinks of greenhouse gases (GHGs). However, most studies on forest soil GHG fluxes are confined to the topsoils (above 20 cm soil depths), with only very limited information being available regarding these fluxes in the subsoils (below 20 cm soil depths), especially in managed forests. This limits deeper understanding of the relative contributions of different soil depths to GHG fluxes and global warming potential (GWP).

Biomechanical study of two-level oblique lumbar interbody fusion with different types of lateral instrumentation: a finite element analysis.

Objective: The aim of this study was to verify the biomechanical properties of a newly designed angulated lateral plate (mini-LP) suited for two-level oblique lumbar interbody fusion (OLIF). The mini-LP is placed through the lateral ante-psoas surgical corridor, which reduces the operative time and complications associated with prolonged anesthesia and placement in the prone position.

Methods: A three-dimensional nonlinear finite element (FE) model of an intact L1-L5 lumbar spine was constructed and validated.

Evolution and Simulation of Terrestrial Ecosystem Carbon Storage and Sustainability Assessment in Karst Areas: A Case Study of Guizhou Province.

Against the background of "carbon neutrality" and sustainable development goals, it is of great significance to assess the carbon storage changes and sustainability of terrestrial ecosystems in order to maintain the coordinated sustainable development of regional ecological economies and the balance of terrestrial ecosystems. In this study, the terrestrial ecosystem carbon storage in Guizhou from 2010 to 2020 was assessed with the InVEST model. Using the PLUS model, the distribution of terrestrial ecosystem carbon storage by 2030 and 2050 was predicted.

is a novel diagnostic and prognostic biomarker in hepatocellular carcinoma.

Background: GDP Dissociation inhibitor 2 () gene has been correlated with some important biological processes in a variety of cancers, whereas the role of in hepatocellular carcinoma (HCC) is ill-defined. We aimed to demonstrate the relationship between and HCC based on The Cancer Genome Atlas (TCGA) data mining.

Methods: The expression of was compared between cancer and normal tissues of 371 HCC patients collected from TCGA-LIHC, and verified in HCC cell lines.

Exogenous Vitamin C-Triggered Surface Charge Conversion of pH/Reduction-Responsive Micelles for the Enhanced Tumor-Specific Activity of Loaded Doxorubicin.

The effective accumulation at tumor sites and endocytosis by tumor cells for anticancer agents in carriers are essential in successful cancer therapy, and both of the processes are affected by the surface charge of drug carriers. In this study, vitamin C (VC) was employed as an "exogenous switch" to trigger the surface charge conversion of DOX-loaded micelles to obtain a better antitumor effect. T micelles formed by poly(ε-caprolactone)--poly(,-diethylaminoethyl methacrylate)-ss--poly(2-methacryloyloxyethyl phosphorylcholine) (PCL-PDEA-ss-PMPC) turned their ζ potentials from +1 mV to +18 mV under treatment of 20 mM VC, while the ζ potentials of control R micelles formed by PCL-ss-P(DEA-r-MPC) almost remained unchanged under the same condition.

pH/redox dual-responsive amphiphilic zwitterionic polymers with a precisely controlled structure as anti-cancer drug carriers.

Responding to the tumor microenvironment, functional polymers can serve as preeminent drug carriers for targeted cancer therapy. Stimuli-responsive polymeric drug carriers are reported with diverse anti-tumor effects for various polymer structures. Thus, three pH/redox dual-responsive amphiphilic zwitterionic polymer 'isomers' with different locations of pH/redox responsive units were prepared to understand the relationship between polymer structure and anti-tumor effect.