Publications by authors named "Ziyi Shan"
Article Synopsis
- Mulberry leaf polysaccharides (MLP) show potential for treating Type 2 Diabetes Mellitus by reducing blood glucose and lipid levels, improving metabolism, and lowering insulin resistance in T2DM rats.
- The study found that MLP helped restore gut microbiota balance by increasing beneficial bacteria like Prevotella, Ruminococcus, and Lactobacillus, which is crucial for gut health.
- MLP also influenced bile acid metabolism by altering the expression of related enzymes and receptors, indicating a connection between gut microbiota and metabolic health in managing diabetes.
Article Synopsis
- High-Protein Mulberry (HPM) leaves were studied for their effects on glucose and lipid metabolism in a six-week experiment involving mice.
- The study found that HPM improved fasting blood glucose, glucose tolerance, and insulin resistance, and it decreased harmful serum lipid levels while increasing beneficial cholesterol levels.
- HPM's impact on metabolic regulation seems to be linked to the activation of key pathways (PI3K/Akt and PPARα/CPT-1), suggesting it may have therapeutic potential worth exploring further.
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested and indigestible polysaccharides. SCFAs play an important role in regulating intestinal energy metabolism and maintaining the homeostasis of the intestinal environment and also play an important regulatory role in organs and tissues outside the gut. In recent years, many studies have shown that SCFAs can regulate inflammation and affect host health, and two main signaling mechanisms have also been identified: the activation of G-protein coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC).
View Article and Find Full Text PDFMetabolic syndrome (MetS) is a clinical condition associated with multiple metabolic risk factors leading to type 2 diabetes mellitus and other metabolic diseases. Recent evidence suggests that modulating adipose tissue to adaptive thermogenesis may offer therapeutic potential for MetS. Xiasangju (XSJ) is a marketed drug and dietary supplement used for the treatment of metabolic disease with anti-inflammatory activity.
View Article and Find Full Text PDFBackground: Mulberry (Morus alba L.) leaf, as a medicinal and food homologous traditional Chinese medicine, has a clear therapeutic effect on type 2 diabetes mellitus (T2DM), yet its underlying mechanisms have not been totally clarified. The study aimed to explore the mechanism of mulberry leaf in the treatment of T2DM through tandem mass tag (TMT)-based quantitative proteomics analysis of skeletal muscle.
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