Publications by authors named "Ziyi Han"

Organic semiconductor single crystals (OSSCs) have garnered considerable attention because of their high charge mobility and atomic-scale smooth surface. However, their large-size high-quality preparation remains challenging due to the inevitable defects and limited growth speed brought by traditional epitaxial growth. Here, we demonstrate a space-confined strategy, named out-of-plane microspacing in-air sublimation (OPMAS), for growing vertically millimeter-sized OSSCs in several minutes by revolutionizing the heterogeneous epitaxial growth mode severely depending on substrates into a spontaneous homogeneous growth mode free from substrates.

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Depression, anxiety and sleep disorders are prevalent psychiatric conditions worldwide, significantly impacting the physical and mental well-being of individuals. The treatment of these conditions poses various challenges, including limited efficacy and potential side effects. Tea, a globally recognized healthful beverage, contains a variety of active compounds.

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Medical image segmentation is a critical task in early disease detection and diagnosis. In recent years, numerous variants of U-Net and Transformer-based models have demonstrated success in medical image segmentation. But these models still have certain limitations, particularly regarding the extraction of semantic information and high computational complexity.

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Gut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, and each of them contributes to diverse aspects of host health. Nevertheless, the influence of interaction among gut microbiota on host health remains uncovered. Here, we showed that the interaction between intestinal fungi and bacteria shaped lung inflammation during infection.

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Article Synopsis
  • The study focuses on the engineering and fabrication of two-dimensional transition-metal dichalcogenides (TMDs), highlighting the challenges in achieving controlled stacking orders and nucleation sites for these materials.
  • An optimized chemical vapor deposition method is presented, allowing the modulation of MoS single crystals from monolayer to multilayer configurations, which enhances their properties significantly.
  • The research demonstrates that phototransistors made from monolayer MoS exhibit exceptional sensitivity and performance, and it explores the use of polarized Raman spectroscopy to understand interlayer interactions, paving the way for advanced optoelectronic applications.
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The intratumor microbiome imbalance in pancreatic cancer promotes a tolerogenic immune response and triggers immunotherapy resistance. Here we show that Lactobacillus rhamnosus GG probiotics, outfitted with a gallium-polyphenol network (LGG@Ga-poly), bolster immunotherapy in pancreatic cancer by modulating microbiota-immune interactions. Upon oral administration, LGG@Ga-poly targets pancreatic tumors specifically, and selectively eradicates tumor-promoting Proteobacteria and microbiota-derived lipopolysaccharides through a gallium-facilitated disruption of bacterial iron respiration.

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The somatic embryo (SE) has bipolar characteristics, which is an ideal material for large-scale microproduction of woody plants represented by apples, and the somatic embryo is also an excellent receptor for genetic transformation. The formation of embryogenic cells is a prerequisite for somatic embryogenesis to occur. The embryogenic cells of apples cannot be obtained without induction of exogenous auxin, but how the auxin pathway regulates this process remains unknown.

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Background: For Rheumatoid Arthritis (RA), a long-term chronic illness, it is essential to identify and describe patient subtypes with comparable goal status and molecular biomarkers. This study aims to develop and validate a new subtyping scheme that integrates genome-scale transcriptomic profiles of RA peripheral blood genes, providing a fresh perspective for stratified treatments.

Methods: We utilized independent microarray datasets of RA peripheral blood mononuclear cells (PBMCs).

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Article Synopsis
  • - High-entropy materials (HEMs), such as FeMnNiVZnPS, offer enhanced energy storage performance due to features like entropy stabilization and complex interactions among multiple components, though predicting their properties remains difficult.
  • - Advanced imaging techniques (STEM-ADF and 4D-STEM) reveal unique atomic structures and strain soliton boundaries in FeMnNiVZnPS, linked to imbalanced stress from varying metal-sulfur bonds.
  • - The study shows that the unique structural and electric field characteristics of FeMnNiVZnPS lead to impressive ion-diffusion rates and high-rate performance, contributing to the development of effective designs for future high-entropy materials.
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Background: Observational evidence suggests that type 1 diabetes mellitus (T1DM) is associated with the risk of osteoporosis (OP). Nevertheless, it is not apparent whether these correlations indicate a causal relationship. To elucidate the causal relationship, a two-sample Mendelian randomization (MR) analysis was performed.

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Due to inherent differences in cellular composition and metabolic behavior with host cells, tumor-harbored bacteria can discriminatorily affect tumor immune landscape. However, the mechanisms by which intracellular bacteria affect antigen presentation process between tumor cells and antigen-presenting cells (APCs) are largely unknown. The invasion behavior of attenuated Salmonella VNP20009 (VNP) into tumor cells is investigated and an attempt is made to modulate this behavior by modifying positively charged polymers on the surface of VNP.

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Improving resource use is a pressing research issue because of the huge potential organic waste market. Composting is a recycling technique, treatment to achieve the dual effect of resource recovery and zero waste. Waste composition varies: for example, chicken manure is rich in protein, straw contains wood fibres, fruit and vegetables contain sugar, and food waste contains starch.

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The effectiveness of various cancer therapies for solid tumors is substantially limited by the highly hypoxic tumor microenvironment (TME). Here, a microalgae-integrated living hydrogel (ACG gel) is developed to concurrently enhance hypoxia-constrained tumor starvation therapy and immunotherapy. The ACG gel is formed following intratumoral injection of a biohybrid fluid composed of alginate, , and glucose oxidase, facilitated by the crossing-linking between divalent ions within tumors and alginate.

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Article Synopsis
  • - **The study highlights the importance of targeted composting regulation to enhance the quality of compost, particularly by converting organic matter into humic acid (HA).
  • ** - **Chicken manure compost typically has low carbon levels, necessitating carbon supplements like lignite, which boosts HA content and increases the complexity of humified components.
  • ** - **Adding lignite not only improves the activity of specific enzymes like laccase but also impacts microbial functions, ultimately enhancing the structural complexity of HA through both microbial interactions and enzymatic processes.
  • **
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This study explored the transformation of inorganic nitrogen, the expression levels of antibiotic resistance genes (ARGs), and the regulatory mechanisms of key species on ARGs and inorganic nitrogen cycling genes (INCGs) under different levels of amoxicillin (AMX) stress. High level of AMX inhibited the accumulation of NH-N, which increased by 531 % relative to the initial. Moreover, AMX to some extent increased the levels of nirS and nirK, which could potentially result in nitrogen loss and the accumulation of NO.

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Article Synopsis
  • - Self-intercalation in two-dimensional (2D) materials allows for the modification of their properties, leading to the development of functional materials crucial for numerous applications. - Researchers successfully synthesized self-intercalated H-phase and T-phase TaS using a temperature-controlled chemical vapor deposition method, achieving a tunable intercalation concentration between 10% and 58%. - The presence of nonperiodic Ta atoms alters the structure and physical properties of TaS, resulting in a consistent nonlinear optical effect across different sample thicknesses and concentrations, revealing a new strategy to enhance optoelectronic characteristics in centrosymmetric 2D materials.
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Transcription factor engineering has unique advantages in improving the performance of microbial cell factories due to the global regulation of gene transcription. Omics analyses and reverse engineering enable learning and subsequent incorporation of novel design strategies for further engineering. Here, we identify the role of the global regulator IhfA for overproduction of free fatty acids (FFAs) using CRISPRi-facilitated reverse engineering and cellular physiological characterization.

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Infectious bone defects are characterized by the partial loss or destruction of bone tissue resulting from bacterial contaminations subsequent to diseases or external injuries. Traditional bone transplantation and clinical methods are insufficient in meeting the treatment demands for such diseases. As a result, researchers have increasingly focused on the development of more sophisticated biomaterials for improved therapeutic outcomes in recent years.

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In self-intercalated two-dimensional (ic-2D) materials, understanding the local chemical environment and the topology of the filling site remains elusive, and the subsequent correlation with the macroscopically manifested physical properties has rarely been investigated. Herein, highly crystalline gram-scale ic-2D TaS crystals were successfully grown by the high-pressure high-temperature method. Employing combined atomic-resolution scanning transmission electron microscopy annular dark field imaging and density functional theory calculations, we systematically unveiled the atomic structures of an atlas of stacking registries in a well-defined √3(a) × √3(a) TaS superlattice.

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saponin active fraction (AJSAF), is a prospective adjuvant with dual Th1/Th2 and Tc1/Tc2 potentiating activity. Its adjuvant activity has previously been proven to be strictly dependent on its spatial co-localization with antigens, highlighting the role of local innate immunity in its mechanisms. However, its potential targets and pathways remain unclear.

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3-hydroxy-12-oleanen-27-oic acid (ATA), a cytotoxic oleanane triterpenoid with C14-COOH isolated from the rhizome of , has been previously proven to possess antitumor activity and may be a promising antitumor agent. However, its molecular mechanisms of antitumor action were still unclear. This study explored the underlying mechanisms of cytotoxicity and potential target of ATA against human colorectal cancer HCT116 cells via integrative analysis of transcriptomics and network pharmacology in combination with in vitro and in vivo experimental validations.

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Background: Growing evidence supports an association between physical activity (PA) and the risk of osteoarthritis (OA), but this may be influenced by confounding and reverse causality. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to reveal the causal relationship between PA and OA.

Methods: MR was performed to explore the causation of PA and OA with genetic variants as instrumental variables.

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Adoptive cell therapy has emerged as a promising approach for cancer treatment. However, the transfer of macrophages exhibits limited efficacy against solid tumors due to the dynamic cellular phenotypic shift from antitumor to protumor states within the immunosuppressive tumor microenvironment. In this study, a strategy of attaching bacteria to macrophages (Mø@bac) is reported that endows adoptively infused macrophages with durable stimulation by leveraging the intrinsic immunogenicity of bacteria.

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Actinidia eriantha polysaccharide (AEPS) is a potent adjuvant with dual Th1 and Th2 potentiating activity. linc-AAM has been previously proved to facilitate the expression of immune response genes (IRGs) in AEPS-activated RAW264.7 macrophages.

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Local lung microbiota is closely associated with lung tumorigenesis and therapeutic response. It is found that lung commensal microbes induce chemoresistance in lung cancer by directly inactivating therapeutic drugs via biotransformation. Accordingly, an inhalable microbial capsular polysaccharide (CP)-camouflaged gallium-polyphenol metal-organic network (MON) is designed to eliminate lung microbiota and thereby abrogate microbe-induced chemoresistance.

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