Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8 T cells.

During chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8 T cells. Nevertheless, exhausted CD8 T (T) cells still preserve certain effector function, and maintaining a reservoir of exhausted cells is of vital importance for virus elimination and tumor eradiation. Despite considerable work interrogating the rejuvenation of T cells, mechanisms underpinning the clonal deletion of T cells remain largely unexplored over the past decade.

COVID-19 Variants and Vaccine Development.

Coronavirus disease 2019 (COVID-19), the global pandemic caused by severe acute respiratory syndrome 2 virus (SARS-CoV-2) infection, has caused millions of infections and fatalities worldwide. Extensive SARS-CoV-2 research has been conducted to develop therapeutic drugs and prophylactic vaccines, and even though some drugs have been approved to treat SARS-CoV-2 infection, treatment efficacy remains limited. Therefore, preventive vaccination has been implemented on a global scale and represents the primary approach to combat the COVID-19 pandemic.

Design of a high speed rat whiskers tracking and symmetry analysis system based on FPGA.

This paper presents a high-speed rat whisker tracking and symmetry analysis system based on FPGA. The system utilizes high-speed image sensors recording rat face videos at 120 and 1000 fps. The Xilinx Ultra96 single computer board is chosen as the platform to implement the system's processing system (PS) and the programmable logic (PL) part.

Chitosan and TiO functionalized polypropylene nonwoven fabrics with visible light induced photocatalytic antibacterial performances.

Chitosan/TiO functionalized polypropylene (CS/TiO/PP) nonwoven fabrics were fabricated through crosslinking of chitosan with glutaraldehyde followed by loading of TiO nanoparticles. The functionalized CS/TiO/PP has super hydrophilicity and excellent visible light induced photocatalytic antibacterial properties owing to the synergistic effects of CS and TiO. The photocatalytic degradation performance was determined by assessing the degradation of methyl blue under simulated visible light irradiation and its recyclability was also evaluated.

Exploring the Agrobacterium-mediated transformation with CRISPR/Cas9 in cucumber (Cucumis sativus L.).

Backgrounds: The narrow genetic basis of cucumber makes breeding of this species difficult. CRISPR/Cas9 system is  characteristic of  simple design, low cost and  high efficiency, which has opened a new path for cucumber functional genetics and the development of cucumber mocular breeding. However, the immature genetic transformation system is the main limiting factor for applying this technology in cucumber.

Preparation of YO/TiO-Loaded Polyester Fabric and Its Photocatalytic Properties under Visible Light Irradiation.

In this study, YO/TiO-loaded polyester fabric was prepared to improve the catalytic activity of the TiO and to increase its reuse efficiency. The samples were systematically characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and infrared spectroscopy (FT-IR). Furthermore, the degradation performance of methyl orange in the presence of simulated visible light irradiation was also investigated.

Mutations in CsPID encoding a Ser/Thr protein kinase are responsible for round leaf shape in cucumber (Cucumis sativus L.).

Two round-leaf mutants, rl-1 and rl-2, were identified from EMS-induced mutagenesis. High throughput sequencing and map-based cloning suggested CsPID encoding a Ser/Thr protein kinase as the most possible candidate for rl-1. Rl-2 was allelic to Rl-1.