Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration.

Infectious bone defects present a significant clinical challenge, characterized by infection, inflammation, and subsequent bone tissue destruction. Traditional treatments, including antibiotic therapy, surgical debridement, and bone grafting, often fail to address these defects effectively. However, recent advancements in biomaterials research have introduced innovative solutions for managing infectious bone defects.

The effects of delayed appropriate antimicrobial therapy on children with Staphylococcus aureus blood infection.

Early appropriate antimicrobial therapy plays a critical role for patients with Staphylococcus aureus bloodstream infection (SAB). We aim to determine the optimal time-window for appropriate antimicrobial therapy and evaluate the effects of delayed therapy on adverse clinical outcomes (in-hospital mortality, sepsis, and septic shock) in children with SAB by propensity score matching (PSM) analysis. Receiver-operating characteristic was used to determine the cut-off point of the time to appropriate therapy (TTAT), the patients were divided into timely and delayed appropriate antimicrobial therapy (delayed therapy) groups accordingly.

The Influencing Factors of "Post-African Swine Fever" Pig Farm Biosecurity: Evidence from Sichuan Province, China.

Effective biosecurity measures are crucial in controlling and preventing major pig diseases, ultimately ensuring farm income and social stability. This study extracted data from 205 farmer surveys in Sichuan Province, China, to construct a biosecurity index system for pig farms. The biosecurity levels of pig farms were evaluated using a projection pursuit method to identify weak areas.

The role of small airway function parameters in preschool asthmatic children.

Background: Small airways are the major sites of inflammation and airway remodeling in all severities of asthma patients. However, whether small airway function parameters could reflect the airway dysfunction feature in preschool asthmatic children remain unclear. We aim to investigate the role of small airway function parameters in evaluating airway dysfunction, airflow limitation and airway hyperresponsiveness (AHR).

Effect of Acute PM2.5 Exposure on Lung Function in Children: A Systematic Review and Meta-Analysis.

Objective: The objective of this study was to conduct a systematic review and meta-analysis to identify the adverse effects of acute PM2.5 exposure on lung function in children.

Design: Systematic review and meta-analysis.

Vancomycin efficiency and safety of a dosage of 40-60 mg/kg/d and corresponding trough concentrations in children with Gram-positive bacterial sepsis.

Background: Optimal vancomycin trough concentrations and dosages remain controversial in sepsis children. We aim to investigate vancomycin treatment outcomes with a dosage of 40-60 mg/kg/d and corresponding trough concentrations in children with Gram-positive bacterial sepsis from a clinical perspective.

Methods: Children diagnosed with Gram-positive bacterial sepsis and received intravenous vancomycin therapy between January 2017 and June 2020 were enrolled retrospectively.

Inappropriate empirical antibiotic therapy was an independent risk factor of pediatric persistent S. aureus bloodstream infection.

Unlabelled: Persistent S. aureus bloodstream infection (PSBSI) increased the incidence of metastatic infection and mortality. We aimed to clarify its risk factors and correlation with metastatic infection and septic shock in children.

Neonatal infection induces long-lasting dysbiosis of the gut microbiota in a mouse model.

Early life is a "critical window" for gut microbiota development, antibiotic use during this period exerts a profound effect on gut microbial dysbiosis and asthma. In clinical practice, antibiotics are usually used in patients with bacterial infections, we previously showed that neonatal pneumonia promoted adult-onset asthma in mice model, while it remains unclear whether neonatal infection have long-term effects on gut microbiota. Neonatal BALB/c mice were inoculated with 5*10 CFU D39 to establish non-lethal pneumonia model.

Robust Nonlinear Tracking Control with Exponential Convergence Using Contraction Metrics and Disturbance Estimation.

This paper presents a tracking controller for nonlinear systems with matched uncertainties based on contraction metrics and disturbance estimation that provides exponential convergence guarantees. Within the proposed approach, a disturbance estimator is proposed to estimate the pointwise value of the uncertainties, with a pre-computable estimation error bounds (EEB). The estimated disturbance and the EEB are then incorporated in a robust Riemannian energy condition to compute the control law that guarantees exponential convergence of actual state trajectories to desired ones.

Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.

Background: Our previous study showed that neonatal S. pneumoniae pneumonia promoted airway smooth muscle myosin heavy chain (SMMHC) expression and AHR development. Researches demonstrated HMGB1, TLR4 and ERK are involved in smooth muscle contractile protein expression, so we hypothesis that HMGB1/TLR4/ERK pathway participated in airway SMMHC overexpression in neonatal S.

Diagnosis and management of protracted bacterial bronchitis: a survey of Chinese pediatricians.

Background: Protracted bacterial bronchitis (PBB) is a common cause of chronic wet cough in children. However, it is often misdiagnosed and inappropriately treated in clinical practices. This study aims to investigate the current diagnosis and management of PBB among Chinese pediatricians.

The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children.

Background: Vitamin A plays a pivotal role in respiratory infection, accurate estimation of vitamin A status was recommended in planning and implementing interventions. As infections affect serum vitamin A productions, the real status need to be adjusted by acute phase protein (APP). Mycoplasma pneumoniae is an important cause of respiratory infection in children, the association between vitamin A concentrations and refractory Mycoplasma pneumoniae pneumonia (RMPP) remains unclear.