Publications by authors named "Ziyao Dang"
Article Synopsis
- The study aimed to assess how the SUMOylation inhibitor TAK981 affects oxidative damage caused by hydrogen peroxide (H2O2) in human retinal pigment epithelial cells (ARPE-19) and its underlying mechanisms.
- An oxidative damage model was created, and various concentrations of TAK981 were tested to see their impact on cell viability, levels of oxidative stress markers, and inflammatory cytokines, while comparing them to control and model groups.
- Results showed that H2O2 reduced cell viability significantly, while TAK981 treatment improved cell survival and reduced oxidative damage and inflammation markers, indicating its potential protective effects against oxidative stress in ARPE-19 cells.
Background: Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage is commonly observed in myopia with tilted optic disc. It presents with typical features on the fundus and follows a self-limiting course. However, due to its complex etiology, clinicians sometimes lack sufficient understanding of it which can easily lead to misdiagnosis or overtreatment.
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