Self-Reconstruction Induced Electronic Metal-Support Interaction for Modulated Cu Sites on TiO Nanofibers in Electrocatalytic Nitrate Conversion.

The Cu active sites have gained great attention in electrochemical nitrate reduction, offering a highly promising method for nitrate removal from water bodies. However, challenges arise from the instability of the Cu state and microscopic structure over prolonged operation, limiting the selectivity and durability of Cu-based electrodes. Herein, a self-reconstructed CuO/TiO nanofibers (CuO/TiO NFs) catalyst, demonstrating exceptional stability over 50 cycles (12 h per cycle), a high NO -N removal rate of 90.

Durable Photo-Pyroelectric Detection in a Diamine-Constructed Lead-Free Hybrid Perovskite Ferroelectric.

As a subcategory of pyroelectric materials, hybrid perovskite ferroelectrics possess substantial pyroelectric properties and exceptional light absorption characteristics, demonstrating significant potential in the photo-pyroelectric (PPE) detection field. Despite the significant advantages of hybrid perovskite ferroelectric materials for PPE detection, both the lead issue and the weak stability from van der Waals interactions in monoamines have hindered their further application. Here, 1D lead-free ferroelectric (BDA)SbBr (1, where BDA is 1,4-butanediammonium) is fabricated to achieve PPE detection.

Comparative efficacy and safety of first-line tyrosine kinase inhibitors in chronic myeloid leukemia: a systematic review and network meta-analysis.

Background: Tyrosine kinase inhibitors (TKIs) have become the preferred drugs for the treatment of chronic phase (CP) chronic myeloid leukemia (CML). This study aims to compare the safety and efficacy of different TKIs as first-line treatments for CML using network meta-analysis (NMA), providing a basis for the precise clinical use of TKIs.

Methods: A systematic search was conducted on PubMed, Cochrane Library, Embase, China National knowledge Infrastructure (CNKI), Wanfang, Chinese Science and Technology Periodical Databases (VIP), SinoMed and ClinicalTrials.

Comprehensive analysis of risk factors (methanol, acetaldehyde and higher alcohols) in alcoholic beverages and their reduction strategies: GC-MS analysis and modified activated carbon adsorption and characterization.

This study endeavors to examine the levels of risk factors in alcoholic beverages and propose mitigation strategies. GC-MS analysis was utilized to assess risk factors in various distilled-spirits. The content of such risk factors in spirits ranked as follows: vodka ≈ gin < baijiu < whiskey < brandy, and all were adhering to the Chinese national standard.

A review of Aconiti Lateralis Radix Praeparata (Fuzi) for kidney disease: phytochemistry, toxicology, herbal processing, and pharmacology.

Background: Aconiti Lateralis Radix Praeparata, commonly known as Fuzi in. traditional Chinese medicine (TCM), is widely utilized in clinical practice despite its inherent toxicity. Since ancient times, TCM practitioners have explored various processing techniques to broaden its clinical applications and enhance its safety profile.

Phytochemistry, pharmacology, toxicology and detoxification of Thunb.: a comprehensive review.

Background: Polygonum multiflorum Thunb. (PM), a kind of perennial plant, belongs to the genus of the family polygonaceae.The dry root of PM (also called Heshouwu), is a traditional Chinese medicine, which has a series of functions and is widely used in clinic for hair lossing, aging, and insomnia.

Multiple Interlayer Interactions Enable Highly Stable X-ray Detection in 2D Hybrid Perovskites.

Metal halide perovskites have outperformed conventional inorganic semiconductors in direct X-ray detection due to their ease of synthesis and intriguing photoelectric properties. However, the operational instability caused by severe ion migration under a high external electric field is still a big concern for the practical application of perovskite detectors. Here, we report a 2D (BPEA)PbI (BPEA = -1-(4-bromophenyl)ethylammonium) perovskite with Br-substituted aromatic spacer capable of introducing abundant interactions, e.

Bidirectional two-sample Mendelian randomization study of association between smoking initiation and atrial fibrillation.

Introduction: The relationship between smoking and heart disease has been frequently reported. Therefore, we aimed to explore the association between smoking initiation and atrial fibrillation.

Methods: Genetic association data pertaining to smoking initiation and atrial fibrillation were obtained from genome-wide association studies (GWAS).

Optimisation and characterisation of KOH-activated carbon obtained from Baijiu spent grains for the mitigation of risk factors in alcoholic beverages.

This study aims to repurpose waste grain from the Baijiu brewing process into activated carbon for mitigating risk factors in alcoholic beverages, enhancing quality and ensuring safety. For attaining the most effective activated carbon, tailored carbon synthesis conditions were identified for diverse alcoholic beverages, optimising strategies. For beverages with low flavour compound content, optimal conditions include 900 °C calcination, 16-hour activation and a 1:2 activation ratio.

Tetrandrine alleviates oxaliplatin-induced mechanical allodynia via modulation of inflammation-related genes.

Oxaliplatin, a platinum-based chemotherapy drug, causes neuropathic pain, yet effective pharmacological treatments are lacking. Previously, we showed that tetrandrine (TET), with anti-inflammatory properties, reduces mechanical allodynia in nerve-injured mice. This study explores the effect of TET on oxaliplatin-induced mechanical allodynia and gene changes in mice.

A Dual-Mechanism Targeted Bioorthogonal Prodrug Therapy.

Bioorthogonal prodrug therapies offer an intriguing two-component system that features enhanced circulating stability and controlled activation on demand. Current strategies often deliver either the prodrug or its complementary activator to the tumor with a monomechanism targeted mechanism, which cannot achieve the desired antitumor efficacy and safety profile. The orchestration of two distinct and orthogonal mechanisms should overcome the hierarchical heterogeneity of solid tumors to improve the delivery efficiency of both components simultaneously for bio-orthogonal prodrug therapies.

The barriers and facilitators for the implementation of clinical practice guidelines in healthcare: an umbrella review of qualitative and quantitative literature.

Objectives: To identify barriers and facilitators of clinical practice guidelines (CPGs) implementation, and map those factors to the theoretical domains framework (TDF) and behavior change wheel (BCW).

Methods: We conducted an umbrella review of systematic reviews. PubMed, Embase, and the Cochrane Library were searched.

Electrospun polylactic acid nanofiber film modified by silver oxide deposited on hemp fibers for antibacterial fruit packaging.

Bacterial and fungal contamination have become major factors in fruit spoilage and damage, posing a potential risk to human health. In this work, polylactic acid (PLA) nanofibers combined with AgO-hemp fibers for a good antimicrobial effect were developed and applied to antimicrobial fruit fresh-keeping packages. The results of molecular simulation calculations showed that the strength of hydrogen bonds between AgO and hemp fibers reached 45.

Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial.

Background: Clinical trial evidence is limited to identify better topical non-steroidal anti-inflammatory drugs (NSAIDs) for treating knee osteoarthritis (OA). We aimed to compare the clinical efficacy and safety of flurbiprofen cataplasms (FPC) with loxoprofen sodium cataplasms (LSC) in treating patients with knee OA.

Methods: This is an open-label, non-inferiority randomized controlled trial conducted at Peking University Shougang Hospital.

Modulating the Active Hydrogen Adsorption on Fe─N Interface for Boosted Electrocatalytic Nitrate Reduction with Ultra-Long Stability.

The electrocatalytic reduction of nitrate (NO ) to nitrogen (N ) is an environmentally friendly approach for efficient N-cycle management (toward a nitrogen-neutral cycle). However, poor catalyst durability and the competitive hydrogen evolution reaction significantly impede its practical application. Interface-chemistry engineering, utilizing the close relationship between the catalyst surface/interface microenvironment and electron/proton transfer process, has facilitated the development of catalysts with high intrinsic activity and physicochemical durability.

Continuous CO capture and methanation over Ni-Ca/AlO dual functional materials.

Although Ni-Ca-based dual functional materials (DFMs) have been examined for CO capture and reduction with H (CCR) for the synthesis of CH, their performance has generally been investigated using single reactors in an oxygen-free environment. In addition, continuous CCR operations have scarcely been investigated. In this study, continuous CCR for the production of CH was investigated using a double reactor system over AlO-supported Ni-Ca DFMs in the presence of O.

The efficacy and safety of prophylactic antibiotics for post-acute stroke infection: A systematic review and meta-analysis.

Aims: Infections are common complications after stroke and associated with unfavourable outcomes. We aimed to evaluate the efficacy and safety of prophylactic antibiotics for post-acute stroke infection.

Methods: We searched PubMed, Embase, the Cochrane Library, SinoMed, China National Knowledge Infrastructure, WanFang Data, China Science and Technology Journal Database, and clinical trial register platforms from inception to 15 February 2022.

Volcano relationships and a new activity descriptor of 2D transition metal-Fe layered double hydroxides for efficient oxygen evolution reaction.

Iron (Fe) sites play a critical role in boosting the catalytic activity of transition metal layered double hydroxide (LDH) electrocatalysts for the oxygen evolution reaction (OER), but the contribution of the Fe content to the catalysis of Fe-doped LDHs is still not well understood. Herein, a series of two-dimensional (2D) Fe-doped MFe-LDHs (M = Co, Ni, Cu, and Mn) was synthesized a general molecular self-assembly method to track the role of Fe in their electrocatalytic OER activities. Besides the revelation of the intrinsic activity trend of NiFe > CoFe > MnFe > CuFe, volcano-shaped relationships among the catalytic activity descriptors, , overpotential, Tafel slope, and turnover frequency (TOF), and the Fe-content in MFe-LDHs, were identified.

Drug-induced torsades de pointes: Disproportionality analysis of the United States Food and Drug Administration adverse event reporting system.

Objective: This study aimed to identify the most common and top drugs associated with the risk of torsades de pointes (TdP) based on the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database.

Materials And Methods: We used OpenVigil 2.1 to query FAERS database and data from the first quarter of 2004 to the third quarter of 2021 were retrieved.