Temperature-Adaptive Organic Scintillators for X-ray Radiography.

Organic phosphorescence or thermally activated delayed fluorescence (TADF) scintillators, while effective in utilizing triplet excitons, are sensitive to temperature changes, which can impact radioluminescence performance. In this study, we have developed a type of temperature-adaptive organic scintillator with phosphorescence and TADF dual emission. These scintillators can automatically switch modes with temperature changes, enabling efficient radioluminescence from 77 to 400 K.

FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle.

FK506-binding protein 5 (FKBP5) is a negative regulator of the glucocorticoid response and may play an important role in regulating metabolic homeostasis in birds. However, limited information is available regarding its role in avian species. This study aimed to clarify the spatiotemporal characteristics of chicken FKBP5 and investigate the effects of exogenous stimuli on its expression.

The investigation of the mechanism underlying variations in oxidative stress tolerance of Lacticaseibacillus paracasei resulting from fermentation methods through endogenous CRISPR-Cas9 editing methodology.

The probiotic effects of lactic acid bacteria make them widely used in human and animal breeding industry. However, the presence of oxidative stress during the production and application process can cause bacterial damage or even death, significantly compromising the functionality of probiotics. Despite its potential for broader application scenarios that could provide a more comprehensive understanding of bacteria's internal adaptation strategies, there is a lack of research investigating oxidative stress from the perspective of culture methods.

Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration.

Birds' glycolipid metabolism has garnered considerable attention due to their fasting blood glucose levels being nearly twice those of mammals. While skeletal muscle is the primary insulin-sensitive tissue in mammals, the effects of insulin on chicken skeletal muscle remain unclear. In this study, the insulin-responsive metabolites were identified in broiler's pectoralis muscle (after 16 h of fasting) using widely targeted metabolomics.

[Response Mechanism and Promotion Path of Habitat Quality to Land Use Change in Hexi Corridor Area].

Scientifically recognizing and mastering the spatial-temporal response of habitat quality to land use change and its internal mechanism is the basis of seeking sustainable development in arid areas. Based on the data of land use in 1990, 2000, 2010, and 2020, the land use transfer matrix model, dynamic attitude and state degree model, InVEST model, and geographically weighted regression model were adopted. The research results were as follows： ① From 1990 to 2020, the area of unused land in Hexi Corridor changed the most, with a decrease of 3 021 km and the cultivated land, construction land, and water area increased by 2 343.

sp. nov., a plant growth-promoting bacterium, isolated from leaves in China.

A Gram-stain-negative, facultatively aerobic, rod-shaped and motile bacterium, designated as CCTCC AB 2023082, was isolated from leaves of in China. Optimal growth occurred at 4-45 ℃ and pH 4.0-10.

Viscosity Reduction and Drag Reduction Performance Analysis of Bionic Excavator Buckets Based on Discrete Element Method.

With the aiming of solving problems with the existing ordinary excavator buckets used in the process of operations (such as heavy digging resistance, ease of adhesion, and others), seven types of bionic buckets and a prototype bucket were designed, based on the contractile-state curve of the earthworm head and the contour curve of the pangolin claw toe. The digging processes of the buckets were simulated using the discrete element method. The results show that, compared with the prototype buckets, all seven types of bionic buckets have significant drag reduction effects at the same digging depth, and the drag reduction effects increase with the decrease of digging speed.

[ protein design in the age of artificial intelligence].

Proteins with specific functions and characteristics play a crucial role in biomedicine and nanotechnology. protein design enables the customization of sequences to produce proteins with desired structures that do not exist in the nature. In recent years, with the rapid development of artificial intelligence (AI), deep learning-based generative models have increasingly become powerful tools, enabling the design of functional proteins with atomic-level precision.

Range extended SP-iToF LiDAR with time-gated and spatially fused imaging.

Light detection and ranging (LiDAR) systems based on indirect time-of-flight (iToF) sensors have garnered considerable interest due to their all-solid-state design, high resolution, high reliability, and cost-effective nature. However, the challenge of extending the operational range of iToF LiDAR systems without compromising the range precision is a significant barrier to their broader application. This paper introduces what we believe to be a novel method to overcome these hurdles, which involves pre-setting the delay between the light pulse emission and the sensor's transfer gates to extend the operational range and utilizing spatial overlap fusion techniques to enhance the range precision.

Incidence trends and specific risk factors of ischemic heart disease and stroke: An ecological analysis based on the Global Burden of Disease 2019.

Distribution of risk factors for cardiovascular diseases has been changing globally, which may account for the discrepant temporal trends of ischemic heart disease (IHD) and stroke. To test the hypothesis and identify potential contributing factors, we designed an ecological study based on the GDB-2019 data and extracted age-standardized incidence rates (ASIRs) of IHD and stroke, and summary exposure values (SEVs) of 87 attributable factors. A declining trend was observed for ASIRs of stroke (globally from 181.

Accelerated biological aging and risk of atrial fibrillation: A cohort study.

Background: Even though aging has been demonstrated to be associated with a higher risk of atrial fibrillation (AF), it is unclear whether biological aging is associated with risk of incident AF.

Objective: This study aimed to investigate the association between biological aging and AF.

Methods: A total of 371,882 participants without AF at baseline from the UK Biobank were included.

Optical terahertz metamaterial switch controlled via high-stability CsPbBr microcrystals.

Dynamic control of terahertz metamaterials using thin organic perovskite active layers has been extensively researched. However, the preparation of organic perovskite devices requires strict environmental conditions, and the devices are prone to hydrolysis in air, which reduces performance. Herein, we report an optical terahertz metamaterial switch controlled via hybridization with high-stability CsPbBr microcrystals prepared through precipitation from a water-dimethylformamide (DMF) mixed-solution.

The Glutamine Synthetases Are Required for Sensory Hair Cell Formation and Auditory Function in Zebrafish.

The development of sensory hair cells (HCs) is closely linked to hearing loss. There are still many unidentified genes that may play a crucial role in HC development and function. Glutamine synthetase, Glul, is expressed in sensory hair cells and auditory organs.

Motion State Estimation with Bandwidth Constraints and Mixed Cyber-Attacks for Unmanned Surface Vehicles: A Resilient Set-Membership Filtering Framework.

This paper investigates the motion state estimation problem of the unmanned surface vehicle (USV) steering system in wireless sensor networks based on the binary coding scheme (BCS). In response to the presence of bandwidth constraints and mixed cyber-attacks in USV communication networks, this paper proposes an improved set-membership state estimation algorithm based on BCS. This algorithm partially addresses the problem of degraded performance in USV steering motion state estimation caused by mixed cyber-attacks and bandwidth constraints.

Interpretable Clinical Decision-Making Application for Etiological Diagnosis of Ventricular Tachycardia Based on Machine Learning.

Ventricular tachycardia (VT) can broadly be categorised into ischemic heart disease, non-ischemic structural heart disease, and idiopathic VT. There are few studies related to the application of machine learning for the etiological diagnosis of VT, and the interpretable methods are still in the exploratory stage for clinical decision-making applications. The aim is to propose a machine learning model for the etiological diagnosis of VT.

Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation.

Background: Although the therapeutic effects of berberine have received some attention in recent years, its potential mechanisms underlying its action against stomach carcinoma (SC) remain unclear. In this study, we aimed to elucidate the mechanisms underlying the effects of berberine against SC using a network pharmacology and experimental verification approach.

Methods: Several publicly available databases were used to collect the targets of berberine and SC.

Codon Bias of the Gene and Transcription Factor EHF in Multiple Species.

Milk production is an essential economic trait in cattle, and understanding the genetic regulation of this trait can enhance breeding strategies. The discoidin domain receptor 1 () gene has been identified as a key candidate gene that influences milk production, and ETS homologous factor (EHF) is recognized as a critical transcription factor that regulates expression. Codon usage bias, which affects gene expression and protein function, has not been fully explored in cattle.