Publications by authors named "Ziyan Imran"
Article Synopsis
- Severe traumatic brain injury (TBI) often causes contusions that can worsen due to swelling or bleeding, significantly impacting recovery outcomes.
- In studies on both human and rat brain tissues, the sulfonylurea receptor 1 (SUR1) was found to be upregulated in specific brain cells, and blocking SUR1 with glibenclamide reduced the worsening of contusions.
- The research identified SUR1-TRPM4 channels as the main pathway contributing to contusion expansion and suggests that targeting these channels may improve treatment options for TBI.
Blast traumatic brain injury (bTBI) affects both military and civilian populations, and often results in chronic deficits in cognition and memory. Chronic glial activation after bTBI has been linked with cognitive decline. Pharmacological inhibition of sulfonylurea receptor 1 (SUR1) with glibenclamide was shown previously to reduce glial activation and improve cognition in contusive models of CNS trauma, but has not been examined in bTBI.
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