MRI-based neuroimaging alterations in immune-related skin diseases: a comprehensive review.

The skin, as the largest organ in the human body, serves as the primary physical barrier and plays a crucial role in the immune defense process. Immune-related skin diseases encompass a spectrum of complex dermatological conditions characterized by aberrant immune responses, including the production of autoantibodies and dysregulation of inflammatory mediators. Growing evidence suggest a heightened prevalence of comorbid neuropsychiatric disorders among patients with immune-related skin diseases, indicative of potential shared pathogenesis.

Astrocytic GluN2A alleviates sleep deprivation-induced elevation of Aβ through regulating neprilysin and AQP4 via the calcineurin/NFAT pathway.

Sleep disorders can increase amyloid beta (Aβ) burden in the brain and are linked to Alzheimer's disease (AD) risk. The precise mechanism by which sleep disturbances elevate Aβ levels is unclear. Our previous study has demonstrated that knocking down encoding gene Grin2a of astrocytic N-methyl-D-aspartate (NMDA) receptors GluN2A subunit could aggravate sleep deprivation (SD)-induced elevation of Aβ, indicating a protective role of astrocytic GluN2A in SD; but the underlying mechanism needs to be further elucidated.

Effects of balance and hamstring training on nonspecific low back pain: A randomized controlled trial.

Low back pain is a prevalent musculoskeletal disorder and affects approximately 70% of the adults in the world. To explore how balance and hamstring training improve individuals with nonspecific lower back pain (NSLBP). A total of 26 NSLBP people were randomly allocated into either the experimental group (EG) (n = 13) or the control group (CG) (n = 13).

Polyphenol-Modified Mg-Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment.

Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, the dynamic nature of the oral cavity, characterized by continuous muscular activity and salivary secretion, poses barriers to sustained drug retention and thereby limits therapeutic efficacy. To address this issue, an approach has been devised that aims to facilitate transdermal delivery of bioactive components to promote the healing of diabetic oral ulcers.

Legumes reduce the effects of salt stress on co-existing grass.

Nitrogen (N) fixing legumes typically enhance the ability of coexisting non-N-fixing species to resist disease and drought, but whether legumes enhance their ability to resist salt stress remains unknown, restricting our ability to explore the potential of legumes to rehabilitate salt-affected ecosystems. We conducted a simulation experiment to examine whether and how legumes influence the response of coexisting grass to salt stress. We compared the effects of salt stress on the plant biomass, root cell viability, antioxidant enzyme activities, soil extracellular enzyme activities and microbial functional gene abundances associated with N and phosphorus (P) cycling between pure grass communities and legume-grass mixtures.

Thumb-sized 3D-Printed cymbal microneedle array (CyMA) for enhanced transdermal drug delivery.

Transdermal drug delivery presents a compelling alternative to both needle injection and oral ingestion of medication, as it enhances patient adherence and convenience through its non-invasive and painless administration method. The use of microneedles penetrates the barrier of the stratum corneum, facilitating the sustained delivery of drugs across the skin. However, their efficacy has been limited by the slow diffusion of molecules and often requires external triggers.

MIC: Breast Cancer Multi-label Diagnostic Framework Based on Multi-modal Fusion Interaction.

The automated diagnosis of low-resolution and difficult-to-recognize breast ultrasound images through multi-modal fusion holds significant clinical value. However, prevailing fusion methods predominantly rely on image modalities, neglecting the textual pathology information, and only benign and malignant diagnosis of breast tumors is not satisfying for clinical applications. Consequently, this paper proposes a novel multi-modal fusion interactive diagnostic framework, termed the MIC framework, to achieve the multi-label classification of breast cancer, namely benign-malignant classification and breast imaging reporting and data system (BI-RADS) 3, 4a, 4b, 4c, and 5 gradings.

[Effect of Dendrobii Officinalis Caulis water extract on hyperviscosity rats based on TLR4/NF-κB/ICAM-1 signaling pathway].

This study aims to reveal the effect and mechanism of Dendrobii Officinalis Caulis water extract on the rat model of hyperviscosity induced by a high-sugar, high-salt, and high-fat diet. Thirty-six male SD rats were randomized into normal, model, Compound Danshen Tablets(0.5 g·kg~(-1)), and low-, medium-, and high-dose(0.

Does the Lens Deflection Angle Affect Laparoscopic Camera Navigation?

In laparoscopic surgery, a 30° lens is frequently used to obtain a wider field of view. However, it is difficult for inexperienced surgeons to maintain the horizontal state of the image in laparoscopic camera navigation (LCN). If there is a great deviation in the camera's horizontal axis, it may result in ambiguous anatomical recognition, which could impair patient safety.

Focus on podocytes: diabetic kidney disease and renal fibrosis - a global bibliometric analysis (2000-2024).

Background: Diabetic kidney disease (DKD) is a common pathway to End-stage renal disease (ESRD). Podocytes are crucial due to their dual barrier functions in kidney diseases. Their role in renal fibrosis and DKD regulatory mechanisms is increasingly studied.

Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis.

Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipose tissue in the pathogenesis of vitiligo, 50 patients newly diagnosed with vitiligo and 40 age- and sex-matched healthy controls were enrolled, and fat mass and distribution using dual-energy X-ray absorptiometry (DXA) and serum adipokine levels using enzyme-linked immunosorbent assay were assessed.

Two-pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect.

Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross-resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a pH and near infrared (NIR) light responsive nanomedicine DOX@FG based on gold nanorods (GNRs) that demonstrated the potential to improve chemotherapy outcomes by overcoming MDR. DOX@FG was constructed by conjugating folic acid (FA) and doxorubicin (DOX) derivatives onto GNRs, where the DOX derivatives possessed an acid-labile hydrazone bond.

N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.

Prostate cancer (PCa) gradually becomes the most common cancer in men in many countries, of which circRNAs and methylated modification exert an essential role in PCa progression. However, the concrete mechanisms of N6-methyladenosine (m6A) modification of circRNAs in PCa remain unclear. In our study, we identified circRPS6KC1, a novel and up-regulated circular RNA in PCa, through circRNA sequencing.

Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research.

Over the past decades, numerous large-scale neuroimaging projects that involved the collection and release of multimodal data have been conducted globally. Distinguished initiatives such as the Human Connectome Project, UK Biobank, and Alzheimer's Disease Neuroimaging Initiative, among others, stand as remarkable international collaborations that have significantly advanced our understanding of the brain. With the advancement of big data technology, changes in healthcare models, and continuous development in biomedical research, various types of large-scale projects are being established and promoted worldwide.

Atractylodes macrocephala Rhizoma alleviates blood hyperviscosity induced by high-fat, high-sugar, and high-salt diet by inhibiting gut-liver inflammation and fibrinogen synthesis.

Ethnopharmacological Relevance: Unhealthy dietary patterns and lifestyle changes have been linked to increased blood viscosity, which is recognized as an important pathogenic factor in cardiovascular and cerebrovascular diseases. The underlying mechanism may involve chronic inflammation resulting from intestinal barrier disruption induced by unhealthy diets. The rhizome of Atractylodes macrocephala Koidz.

Prevalence, Clinical Characteristics, and Relative Factors of Acquired Punctal Stenosis in Adult Allergic Conjunctivitis Patients.

Introduction: The objective of this study was to investigate the prevalence, characteristics, and risk factors of acquired punctal stenosis (APS) in adult patients with allergic conjunctivitis (AC).

Methods: This observational case series study included 210 adult AC patients at Zhongshan Ophthalmic Center. The demographic data were collected, and the ocular manifestations were assessed.

MIDC: Medical image dataset cleaning framework based on deep learning.

Deep learning technology is widely used in the field of medical imaging. Among them, Convolutional Neural Networks (CNNs) are the most widely used, and the quality of the dataset is crucial for the training of CNN diagnostic models, as mislabeled data can easily affect the accuracy of the diagnostic models. However, due to medical specialization, it is difficult for non-professional physicians to judge mislabeled medical image data.

The impact of cryosphere service change on the social-ecological systems resilience: Evidence from the Qilian Mountains Area in China.

Research on changes in cryosphere services is crucial for the responsible management of cryospheric resources and for fostering sustainable development in Social-Ecological Systems (SESs) impacted by the cryosphere. While previous research has primarily focused on quantifying cryospheric change through Cryosphere Service Value (CSV), the impact of cryosphere service change on Social-Ecological Systems Resilience (SESR) remains unclear. This study considers the Qilian Mountains as a cryosphere system and assesses the changes in its service value from 2000 to 2020.

Cytarabine chemotherapy induces meibomian gland dysfunction.

Purpose: Cytarabine (Ara-C) chemotherapy causes symptoms resembling meibomian gland dysfunction (MGD), suggesting potential associations between Ara-C and MGD. In this study, the pathological effects of Ara-C on MGD were investigated in a rodent model.

Methods: Mice received Ara-C with or without rosiglitazone (PPARγ agonist) for 7 consecutive days.

The role of JNK signaling pathway in organ fibrosis.

Background: Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even organ failure until death. Up to now, there is still no specific drugs or strategies can effectively block or changeover tissue fibrosis. JNKs, a subset of mitogen-activated protein kinases (MAPK), have been reported that participates in various biological processes, such as genetic expression, DNA damage, and cell activation/proliferation/death pathways.

Synergistic activity of m-induced ferroptosis via expansion of IFN-γCD8 T cell population in advanced hepatocellular carcinoma treated with sorafenib.

The gut microbiota plays an important role in the development and treatment of hepatocellular carcinoma (HCC). However, the implication of specific gut microbiota in targeted sorafenib therapy for advanced HCC and the microbiota mode of action, remain to be elucidated. Here, we confirmed that four bacterial genera, , , and , are associated with the therapeutic efficacy of Sorafenib, and that (Efm) plays a crucial role in modulating the sorafenib activity.