Publications by authors named "Ziyan Chen"

The skin, as the largest organ in the human body, serves as the primary physical barrier and plays a crucial role in the immune defense process. Immune-related skin diseases encompass a spectrum of complex dermatological conditions characterized by aberrant immune responses, including the production of autoantibodies and dysregulation of inflammatory mediators. Growing evidence suggest a heightened prevalence of comorbid neuropsychiatric disorders among patients with immune-related skin diseases, indicative of potential shared pathogenesis.

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Sleep disorders can increase amyloid beta (Aβ) burden in the brain and are linked to Alzheimer's disease (AD) risk. The precise mechanism by which sleep disturbances elevate Aβ levels is unclear. Our previous study has demonstrated that knocking down encoding gene Grin2a of astrocytic N-methyl-D-aspartate (NMDA) receptors GluN2A subunit could aggravate sleep deprivation (SD)-induced elevation of Aβ, indicating a protective role of astrocytic GluN2A in SD; but the underlying mechanism needs to be further elucidated.

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Low back pain is a prevalent musculoskeletal disorder and affects approximately 70% of the adults in the world. To explore how balance and hamstring training improve individuals with nonspecific lower back pain (NSLBP). A total of 26 NSLBP people were randomly allocated into either the experimental group (EG) (n = 13) or the control group (CG) (n = 13).

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Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, the dynamic nature of the oral cavity, characterized by continuous muscular activity and salivary secretion, poses barriers to sustained drug retention and thereby limits therapeutic efficacy. To address this issue, an approach has been devised that aims to facilitate transdermal delivery of bioactive components to promote the healing of diabetic oral ulcers.

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Nitrogen (N) fixing legumes typically enhance the ability of coexisting non-N-fixing species to resist disease and drought, but whether legumes enhance their ability to resist salt stress remains unknown, restricting our ability to explore the potential of legumes to rehabilitate salt-affected ecosystems. We conducted a simulation experiment to examine whether and how legumes influence the response of coexisting grass to salt stress. We compared the effects of salt stress on the plant biomass, root cell viability, antioxidant enzyme activities, soil extracellular enzyme activities and microbial functional gene abundances associated with N and phosphorus (P) cycling between pure grass communities and legume-grass mixtures.

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Transdermal drug delivery presents a compelling alternative to both needle injection and oral ingestion of medication, as it enhances patient adherence and convenience through its non-invasive and painless administration method. The use of microneedles penetrates the barrier of the stratum corneum, facilitating the sustained delivery of drugs across the skin. However, their efficacy has been limited by the slow diffusion of molecules and often requires external triggers.

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The automated diagnosis of low-resolution and difficult-to-recognize breast ultrasound images through multi-modal fusion holds significant clinical value. However, prevailing fusion methods predominantly rely on image modalities, neglecting the textual pathology information, and only benign and malignant diagnosis of breast tumors is not satisfying for clinical applications. Consequently, this paper proposes a novel multi-modal fusion interactive diagnostic framework, termed the MIC framework, to achieve the multi-label classification of breast cancer, namely benign-malignant classification and breast imaging reporting and data system (BI-RADS) 3, 4a, 4b, 4c, and 5 gradings.

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This study aims to reveal the effect and mechanism of Dendrobii Officinalis Caulis water extract on the rat model of hyperviscosity induced by a high-sugar, high-salt, and high-fat diet. Thirty-six male SD rats were randomized into normal, model, Compound Danshen Tablets(0.5 g·kg~(-1)), and low-, medium-, and high-dose(0.

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In laparoscopic surgery, a 30° lens is frequently used to obtain a wider field of view. However, it is difficult for inexperienced surgeons to maintain the horizontal state of the image in laparoscopic camera navigation (LCN). If there is a great deviation in the camera's horizontal axis, it may result in ambiguous anatomical recognition, which could impair patient safety.

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Background: Diabetic kidney disease (DKD) is a common pathway to End-stage renal disease (ESRD). Podocytes are crucial due to their dual barrier functions in kidney diseases. Their role in renal fibrosis and DKD regulatory mechanisms is increasingly studied.

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Article Synopsis
  • Memory consolidation during sleep depends on brain areas like the cortex, thalamus, and hippocampus, but how insomnia disrupts their metabolic patterns is still unclear.
  • This study investigates how insomnia affects metabolites related to memory consolidation, using both clinical research with human participants and experimental studies with rats.
  • Findings show that insomnia with mild cognitive impairment is associated with lower GABA levels, while sleep deprivation in rats worsens metabolic imbalances in the hippocampus, linking these changes to cognitive decline.
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  • The acoustic virtual 3D scaffold (AV-Scaf) method allows for effective culturing of tumor organoids without traditional bioscaffolds, making it easier to manipulate and study these organoids.
  • The technology enhances the self-organization of tumor cells and boosts calcium ion influx, promoting stronger interactions among cells in the culture.
  • Coculturing melanoma organoids with T cells using AV-Scaf leads to significant T cell activation, evidenced by increased levels of granzyme B and interferon-γ, which could advance research in cancer and immunotherapy.
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Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipose tissue in the pathogenesis of vitiligo, 50 patients newly diagnosed with vitiligo and 40 age- and sex-matched healthy controls were enrolled, and fat mass and distribution using dual-energy X-ray absorptiometry (DXA) and serum adipokine levels using enzyme-linked immunosorbent assay were assessed.

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Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross-resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a pH and near infrared (NIR) light responsive nanomedicine DOX@FG based on gold nanorods (GNRs) that demonstrated the potential to improve chemotherapy outcomes by overcoming MDR. DOX@FG was constructed by conjugating folic acid (FA) and doxorubicin (DOX) derivatives onto GNRs, where the DOX derivatives possessed an acid-labile hydrazone bond.

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Prostate cancer (PCa) gradually becomes the most common cancer in men in many countries, of which circRNAs and methylated modification exert an essential role in PCa progression. However, the concrete mechanisms of N6-methyladenosine (m6A) modification of circRNAs in PCa remain unclear. In our study, we identified circRPS6KC1, a novel and up-regulated circular RNA in PCa, through circRNA sequencing.

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Over the past decades, numerous large-scale neuroimaging projects that involved the collection and release of multimodal data have been conducted globally. Distinguished initiatives such as the Human Connectome Project, UK Biobank, and Alzheimer's Disease Neuroimaging Initiative, among others, stand as remarkable international collaborations that have significantly advanced our understanding of the brain. With the advancement of big data technology, changes in healthcare models, and continuous development in biomedical research, various types of large-scale projects are being established and promoted worldwide.

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Ethnopharmacological Relevance: Unhealthy dietary patterns and lifestyle changes have been linked to increased blood viscosity, which is recognized as an important pathogenic factor in cardiovascular and cerebrovascular diseases. The underlying mechanism may involve chronic inflammation resulting from intestinal barrier disruption induced by unhealthy diets. The rhizome of Atractylodes macrocephala Koidz.

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Introduction: The objective of this study was to investigate the prevalence, characteristics, and risk factors of acquired punctal stenosis (APS) in adult patients with allergic conjunctivitis (AC).

Methods: This observational case series study included 210 adult AC patients at Zhongshan Ophthalmic Center. The demographic data were collected, and the ocular manifestations were assessed.

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Article Synopsis
  • This study investigated imaging artefacts in the lacrimal gland using SS-OCT in patients with dry eye disease (DED) and healthy participants.
  • A total of 151 eyes were analyzed, categorizing artefacts into various types and severities, revealing that DED patients had significantly more artefacts compared to healthy individuals.
  • Key findings showed that artefacts were strongly associated with DED and higher intraocular pressure, highlighting the need for improved image quality control in SS-OCT assessments of the lacrimal gland.
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Deep learning technology is widely used in the field of medical imaging. Among them, Convolutional Neural Networks (CNNs) are the most widely used, and the quality of the dataset is crucial for the training of CNN diagnostic models, as mislabeled data can easily affect the accuracy of the diagnostic models. However, due to medical specialization, it is difficult for non-professional physicians to judge mislabeled medical image data.

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Research on changes in cryosphere services is crucial for the responsible management of cryospheric resources and for fostering sustainable development in Social-Ecological Systems (SESs) impacted by the cryosphere. While previous research has primarily focused on quantifying cryospheric change through Cryosphere Service Value (CSV), the impact of cryosphere service change on Social-Ecological Systems Resilience (SESR) remains unclear. This study considers the Qilian Mountains as a cryosphere system and assesses the changes in its service value from 2000 to 2020.

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Purpose: Cytarabine (Ara-C) chemotherapy causes symptoms resembling meibomian gland dysfunction (MGD), suggesting potential associations between Ara-C and MGD. In this study, the pathological effects of Ara-C on MGD were investigated in a rodent model.

Methods: Mice received Ara-C with or without rosiglitazone (PPARγ agonist) for 7 consecutive days.

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  • The treatment of infected bone defects (IBDs) requires both eliminating infection and promoting bone regeneration, but iron competition between pathogens and host cells creates a disadvantageous microenvironment.
  • A new method involves using iron-active multifunctional scaffolds made from iron gallate-modified hydroxyapatite and poly(lactic-co-glycolic acid) to create a composite that enhances healing.
  • Tests show that these scaffolds not only fight bacteria through photothermal effects but also restore iron balance, leading to reduced inflammation and improved bone repair, indicating their potential for future clinical use.
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Background: Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even organ failure until death. Up to now, there is still no specific drugs or strategies can effectively block or changeover tissue fibrosis. JNKs, a subset of mitogen-activated protein kinases (MAPK), have been reported that participates in various biological processes, such as genetic expression, DNA damage, and cell activation/proliferation/death pathways.

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The gut microbiota plays an important role in the development and treatment of hepatocellular carcinoma (HCC). However, the implication of specific gut microbiota in targeted sorafenib therapy for advanced HCC and the microbiota mode of action, remain to be elucidated. Here, we confirmed that four bacterial genera, , , and , are associated with the therapeutic efficacy of Sorafenib, and that (Efm) plays a crucial role in modulating the sorafenib activity.

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