Publications by authors named "Ziyadullaev Shukhrat"
Article Synopsis
- The study focuses on how the NLRP3 inflammasome contributes to cell death (pyroptosis) in macrophages during sepsis, leading to acute lung injury (ALI), and investigates the protective effects of tangeretin (TAN), a compound found in citrus peels.
- TAN was tested in both mice and cell culture models, showing it reduces inflammation and lung damage due to sepsis, such as pulmonary edema and fibrosis, while also suppressing inflammatory markers.
- The research identified Polo-like kinase 1 (PLK1) as a key target for TAN's action, as it prevents the decline in PLK1 levels and impacts related processes involved in inflammation and mitochondrial function in the context of sepsis-induced ALI
Objectives: Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties.
Materials And Methods: The MTT assay was used to assess the cytotoxic activity of corosolic acid on MDA-MB-231 and MCF7 cell lines.
Heavy metals (HM) are among the elements that are rare in nature and threaten human health, animals, and the environment. Fix sources including (power plants, industries, homes) and mobile sources include (cars and motorcycles) are the main sources production and emission of HM. It is important to understand the main information about sources of emission, chemical processes (reactions, oxidation, and leaching), and how they precipitate.
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- Research shows miRNA-128 (miR-128) plays a crucial role in the initiation and development of various cancers, impacting immune responses.
- There is potential for miR-128 to be used as a biomarker and a focus for new anticancer treatments due to its abnormal expression in tumors.
- The review explores miR-128's role in multiple cancers and discusses its influence on resistance to treatments and immunotherapy through exosomes.
Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological functions, including the regulation of sphingolipid metabolism, platelet aggregation, and apoptosis. However, it has been found that metabolites derived from cholesterol play essential functions in cancer development and immunological suppression.
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