The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis.

Although chromatin remodelers are among the most important risk genes associated with neurodevelopmental disorders (NDDs), the roles of these complexes during brain development are in many cases unclear. Here, we focused on the recently discovered ChAHP chromatin remodeling complex. The zinc finger and homeodomain transcription factor ADNP is a core subunit of this complex, and de novo mutations lead to intellectual disability and autism spectrum disorder.

Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1.

Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body temperature (T) decreases via unknown mechanisms to conserve energy. In small mammals, non-shivering thermogenesis in brown adipose tissue (BAT) is critical to T regulation; therefore, we hypothesize that hypoxia decreases naked mole-rat BAT thermogenesis.