On the Specific Status of Rhinogobius zhoui (Gobiiformes, Gobiidae) with mtDNA Characterization.

Rhinogobius zhoui is found only in streams on Lianhua Mountain, Guangdong Province, China. Juveniles of Rhinogobius zhoui bred in an artificial environment do not undergo a planktonic period and have a landlocked life history. At present, there is not much published literature regarding this species.

Reimagining cancer tissue classification: a multi-scale framework based on multi-instance learning for whole slide image classification.

In cancer pathology diagnosis, analyzing Whole Slide Images (WSI) encounters challenges like invalid data, varying tissue features at different magnifications, and numerous hard samples. Multiple Instance Learning (MIL) is a powerful tool for addressing weakly supervised classification in WSI-based pathology diagnosis. However, existing MIL frameworks cannot simultaneously tackle these issues.

Policy and care in tandem: structuring youth volunteerism for psychological benefits in pediatric palliative care.

Terminally ill children (TIC) in pediatric palliative care often encounter psychological deprivation due to isolation, impacting their self-discovery and identity formation. The Young Pioneer Voluntary Teams (YPVTs), initiated by the Ministry of Education of China, address these challenges while also benefiting adolescents with enhanced self-esteem and self-efficacy. However, the current lack of a standardized approach in integrating youth volunteerism into pediatric care raises concerns about potential negative impacts on TIC.

Development and validation of potential molecular subtypes and signatures of thyroid eye disease based on angiogenesis-related gene analysis.

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disorder of the orbit, associated with a range of potential clinical sequelae. Tumor cells in TED overexpress pro-angiogenic factors, driving the formation of heterogeneous and immature neovascularization. This dysregulated angiogenesis often leads to a hypoxic microenvironment due to insufficient perfusion.

Molecular insights into ulcerative colitis and orbital inflammation.

Ulcerative colitis (UC) is an increasingly prevalent inflammatory condition affecting the intestinal mucosa, while nonspecific orbital inflammation (NSOI) is a common non-neoplastic orbital disorder. Exploring the molecular interplay between UC and NSOI may help physicians make earlier diagnoses and enhance treatment approaches. We analyzed gene expression datasets (GSE58331, GSE105149, GSE206285, and GSE179285) for UC and NSOI from the GEO database.

Hydrophobic cellulose nanofiber based aerogel for high-efficiency oil-water separation.

Hydrophobic aerogel has emerged as an effective material for oil absorption. In this study, we fabricated four types of hydrophobic nanocellulose (NC)-based aerogels through a freeze-drying method with methyltrimethoxysilane (MTMS) surface modification for enhanced oil removal. It involved tuning the functional groups of NC (cellulose nanofibers (CNF) and TEMPO-oxidized cellulose nanofibers (TCNF)) and selection of crosslinkers (polyethyleneimine (PEI) and tannic acid (TA)).

Carboxymethylated polysaccharides from Chrysanthemum indicum with antimicrobial and hemostatic properties for promoting wound healing.

Seeking potential active ingredients with suitable functions to promote the entire wound repair process remains an unmet requirement. In this study, the polysaccharide (CIP) with an average molecular weight of 5.85 × 10 g/mol was isolated from dried Chrysanthemum indicum flowers.

Transcriptomic Analysis of Gills Following FPPS Knockdown Reveals Its Regulatory Role in Immune Response.

Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the terpenoid biosynthesis pathway, responsible for converting isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) into farnesyl pyrophosphate (FPP). In crustaceans, FPPS plays an important role in various physiological processes, particularly in synthesizing the crustacean-specific hormone methyl farnesoate (MF). This study analyzed the evolutionary differences in the physicochemical properties, subcellular localization, gene structure, and motif composition of FPPS in (named NdFPPS) compared to other species.

Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression.

Somatic cells can be reprogrammed into pluripotent stem cells (iPSCs) by overexpressing defined transcription factors. Specifically, overexpression of OCT4 alone has been demonstrated to reprogram mouse fibroblasts into iPSCs. However, it remains unclear whether any other single factor can induce iPSCs formation.

Moiré metasurfaces with tunable near-infrared-I chiroptical responses for biomolecular chirality discrimination.

Manipulating circular dichroism in chiral metasurfaces has been increasingly important for a wide range of polarization-sensitive photonic applications. However, simple methods for presenting chiral nanostructures with tunable and considerable chiroptical responses in the near-infrared-I regime remains underexplored. Herein, two sheets of suspended symmetric bilayer metagratings fabricated single-step electron beam lithography are stacked into a moiré metasurface with its circular dichroism value reaching up to 20.

Music-induced emotion flow modeling by ENMI Network.

The relation between emotions and music is substantial because music as an art can evoke emotions. Music emotion recognition (MER) studies the emotions that music brings in the effort to map musical features to the affective dimensions. This study conceptualizes the mapping of music and emotion as a multivariate time series regression problem, with the aim of capturing the emotion flow in the Arousal-Valence emotional space.

Integrated analysis of transcriptome and metabolome reveals chronic low salinity stress responses in the muscle of Exopalaemon carinicauda.

Low salinity environment is one of the key factors threatening the survival of aquatic organisms. Due to the strong adaptability of low salinity, Exopalaemon carinicauda is an ideal model to study the low salinity adaptation mechanism of crustaceans. In this study, E.

Integrated machine learning and Mendelian randomization reveal PALMD as a prognostic biomarker for nonspecific orbital inflammation.

Background: Nonspecific Orbital Inflammation (NSOI) remains a perplexing enigma among proliferative inflammatory disorders. Its etiology is idiopathic, characterized by distinctive and polymorphous lymphoid infiltration within the orbital region. Preliminary investigations suggest that PALMD localizes within the cytosol, potentially playing a crucial role in cellular processes, including plasma membrane dynamics and myogenic differentiation.

Soluble trehalase responds to heavy metal stimulation by regulating apoptosis in Neocaridina denticulata sinensis.

Trehalase plays an important role in insect metabolism and development by hydrolyzing blood sugar trehalose, but it seems to perform primarily an immunomodulatory function in crustaceans whose blood sugar is glucose. Metal ions as pollutants seriously affecting crustacean health, but studies on trehalase in metal immunity are still limited. In this study, a soluble trehalase (NdTre1) that could bind to multiple metals was identified from Neocaridina denticulata sinensis for investigating metal resistance.

Generating Airy surface acoustic waves with dislocated interdigital transducers.

We propose an innovative design for interdigital transducers (IDTs), enabling phase modulation of surface acoustic waves (SAWs) with a dislocated electrode structure. By designing the size and arrangement of these dislocated IDTs, a novel type of Airy SAWs can be generated, exhibiting self-accelerating, self-bending, and self-healing characteristics. The acceleration of the generated Airy SAW is 0.

The effectiveness of nirmatrelvir/ritonavir regimen in hospitalized renal transplant patients with prolonged COVID-19 infection: a multicenter clinical experience.

Objectives: Effectiveness of nirmatrelvir/ritonavir (NR) in kidney transplant recipients (KTRs) infected COVID-19 for more than 5 days has not been evaluated.

Methods: In this multicenter retrospective study, 85 KTRs with COVID-19 were enrolled, including 50 moderate, 21 severe, and 14 critical patients.

Results: The median time from onset to starting NR treatment was 14 (IQR, 11-19) days.

Deciphering the role of HLF in idiopathic orbital inflammation: integrative analysis via bioinformatics and machine learning techniques.

Idiopathic orbital inflammation, formerly known as NSOI (nonspecific orbital inflammation), is characterized as a spectrum disorder distinguished by the polymorphic infiltration of lymphoid tissue, presenting a complex and poorly understood etiology. Recent advancements have shed light on the HLF (Human lactoferrin), proposing its critical involvement in the regulation of hematopoiesis and the maintenance of innate mucosal immunity. This revelation has generated significant interest in exploring HLF's utility as a biomarker for NSOI, despite the existing gaps in our understanding of its biosynthetic pathways and operational mechanisms.

Elucidating the pan-oncologic landscape of S100A9: prognostic and therapeutic corollaries from an integrative bioinformatics and Mendelian randomization analysis.

The calcium-binding protein S100A9 has emerged as a pivotal biomolecular actor in oncology, implicated in numerous malignancies. This comprehensive bioinformatics study transcends traditional boundaries, investigating the prognostic and therapeutic potential of S100A9 across diverse neoplastic entities. Leveraging a wide array of bioinformatics tools and publicly available cancer genomics databases, such as TCGA, we systematically examined the S100A9 gene.

The shared mechanism and potential diagnostic markers for premature ovarian failure and dry eye disease.

Premature ovarian failure (POF), which is often comorbid with dry eye disease (DED) is a key issue affecting female health. Here, we explored the mechanism underlying comorbid POF and DED to further elucidate disease mechanisms and improve treatment. Datasets related to POF (GSE39501) and DED (GSE44101) were identified from the Gene Expression Omnibus (GEO) database and subjected to weighted gene coexpression network (WGCNA) and differentially expressed genes (DEGs) analyses, respectively, with the intersection used to obtain 158 genes comorbid in POF and DED.

Mechanism of drug-pairs Astragalus Mongholicus-Largehead Atractylodes on treating knee osteoarthritis investigated by GEO gene chip with network pharmacology and molecular docking.

Investigations into the therapeutic potential of Astragalus Mongholicus (AM, huáng qí) and Largehead Atractylodes (LA, bái zhú) reveal significant efficacy in mitigating the onset and progression of knee osteoarthritis (KOA), albeit with an elusive mechanistic understanding. This study delineates the primary bioactive constituents and their molecular targets within the AM-LA synergy by harnessing the comprehensive Traditional Chinese Medicine (TCM) network databases, including TCMSP, TCMID, and ETCM. Furthermore, an analysis of 3 gene expression datasets, sourced from the gene expression omnibus database, facilitated the identification of differential genes associated with KOA.

Spontaneous Generation of Unconventional Language and Its Link with Grammatical Performance in Chinese Adults With and Without ASD.

This study investigated the generation of unconventional language in the spontaneous speech of Chinese adults with autism spectrum disorder (ASD), and how it was related to their grammatical performance, when compared to neurotypical (NT) controls. Twenty Cantonese-speaking adults with ASD and 20 NT controls completed three interview tasks in the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), and their spontaneous speech was recorded and transcribed. Utterances containing unconventional language (neologisms, idiosyncratic phrases, and pedantic language), morphosyntactic errors, mean length of utterance (MLU), and mazes were computed.

Research on the loading and release kinetics of the vincristine sulfate liposomes and its anti-breast cancer activity.

Vincristine (VCR), as a cytotoxic drug, is used clinically to treat acute lymphatic leukemia and breast cancer, and commonly used clinically as vincristine sulfate (VCRS). However, its clinical use is limited by unpredictable pharmacologic characteristics, a narrow therapeutic index, and neurotoxicity. The pH gradient method was used for active drug loading of VCRS, and the process route mainly includes the preparation of blank liposomes and drug-loaded liposomes.

Elucidating the multifaceted roles of GPR146 in non-specific orbital inflammation: a concerted analytical approach through the prisms of bioinformatics and machine learning.

Background: Non-specific Orbital Inflammation (NSOI) is a chronic idiopathic condition marked by extensive polymorphic lymphoid infiltration in the orbital area. The integration of metabolic and immune pathways suggests potential therapeutic roles for C-peptide and G protein-coupled receptor 146 (GPR146) in diabetes and its sequelae. However, the specific mechanisms through which GPR146 modulates immune responses remain poorly understood.

The roles of IRF8 in nonspecific orbital inflammation: an integrated analysis by bioinformatics and machine learning.

Background: Nonspecific Orbital Inflammation (NSOI) represents a persistent and idiopathic proliferative inflammatory disorder, characterized by polymorphous lymphoid infiltration within the orbit. The transcription factor Interferon Regulatory Factor 8 (IRF8), integral to the IRF protein family, was initially identified as a pivotal element for the commitment and differentiation of myeloid cell lineage. Serving as a central regulator of innate immune receptor signaling, IRF8 orchestrates a myriad of functions in hematopoietic cell development.