Upregulated PrP by HBx enhances NF-κB signal via liquid-liquid phase separation to advance liver cancer.

Cellular prion protein (PrP) has been implicated in carcinogenic through the activation of various signal pathways, however, the precise mechanisms remain elusive. In vitro studies have shown that PrP is prone to undergo liquid-liquid phase separation (LLPS). However, it remains unknown whether PrP contributes to LLPS-inducing cancer development.