A novel prognostic signature based on smoking-associated genes for predicting prognosis and immune microenvironment in NSCLC smokers.

Background: As a highly heterogeneous tumor, non-small cell lung cancer (NSCLC) is famous for its high incidence and mortality worldwide. Smoking can cause genetic changes, which leading to the occurrence and progress of NSCLC. Nevertheless, the function of smoking-related genes in NSCLC needs more research.

An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death.

Cancer cells have a strategically optimized metabolism and tumor microenvironment for rapid proliferation and growth. Increasing research efforts have been focused on developing therapeutic agents that specifically target the metabolism of cancer cells. In this work, we prepared 1-methyl-4-phenylpyridinium-functionalized Ir(iii) complexes that selectively localize in the mitochondria and generate singlet oxygen and superoxide anion radicals upon two-photon irradiation.

miR-6076 targets BCL6 in SH-SY5Y cells to regulate amyloid-β-induced neuronal damage.

Amyloid-β (Aβ ) is strongly associated with Alzheimer's disease (AD). The aim of this study is to elucidate whether and how miR-6076 participates in the modulation of amyloid-β (Aβ)-induced neuronal damage. To construct the neuronal damage model, SH-SY5Y cells were treated with Aβ .

Medical Applications and Advancement of Near Infrared Photosensitive Indocyanine Green Molecules.

Indocyanine green (ICG) is an important kind of near infrared (NIR) photosensitive molecules for PTT/PDT therapy as well as imaging. When exposed to NIR light, ICG can produce reactive oxygen species (ROS), which can kill cancer cells and pathogenic bacteria. Moreover, the absorbed light can also be converted into heat by ICG molecules to eliminate cancer cells.

Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma.

Melanoma represents the most fatal form of skin cancer due to its resistance mechanisms and high capacity for the development of metastases. Among other medicinal techniques, photodynamic therapy is receiving increasing attention. Despite promising results, the application of photodynamic therapy is inherently limited due to interference from melanin, poor tissue penetration of photosensitizers, low loading into drug delivery systems, and a lack of tumor selectivity.

Highly hydrostable and flexible opal photonic crystal film for enhanced up-conversion fluorescence sensor of COVID-19 antibody.

Efficient detection of related markers is significant for the early screening of COVID-19. Near infrared (NIR) light excited up-conversion fluorescence probes are ideal for biosensing but limited by the low luminescence efficiency. In this work, a novel highly stable opal photonic crystal (OPC) structure was designed to provide an OPC effect for up-conversion fluorescence enhancement, and sensitive Novel Coronavirus IgG up-conversion FRET-based sensor was further constructed.

miR-6216 regulates neural stem cell proliferation by targeting RAB6B.

Neural stem cells (NSCs) are a class of self-renewing, multipotent and undifferentiated progenitor cells that retain the capacity to both glial and neuronal lineages. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in stem cell fate determination and self-renewal. Our previous RNA-seq data indicated that the expression of miR-6216 was decreased in denervated hippocampal exosomes compared with normal.

Spatial temporal Fourier single-pixel imaging.

Generally, the imaging quality of Fourier single-pixel imaging (FSI) will severely degrade while achieving high-speed imaging at a low sampling rate (SR). To tackle this problem, a new, to the best of our knowledge, imaging technique is proposed: firstly, the Hessian-based norm constraint is introduced to deal with the staircase effect caused by the low SR and total variation regularization; secondly, based on the local similarity prior of consecutive frames in the time dimension, we designed the temporal local image low-rank constraint for the FSI, and combined the spatiotemporal random sampling method, the redundancy image information of consecutive frames can be utilized sufficiently; finally, by introducing additional variables to decompose the optimization problem into multiple sub-problems and analytically solving each one, a closed-form algorithm is derived for efficient image reconstruction. Experimental results show that the proposed method improves imaging quality significantly compared with state-of-the-art methods.

High-speed three-dimensional shape measurement based on tripartite complementary Gray-coded light.

In phase-shifting profilometry based on the Gray code, the jump error is inevitably generated and is further amplified in dynamic scenes. To tackle this problem, we propose the robust tripartite complementary Gray code method (TCG). Without projecting additional patterns, TCG uses different combinations of Gray code to calculate three complementary orders able to avoid jump error in the unwrapping process.

Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis.

Hereditary (variant) transthyretin amyloidosis (ATTRv amyloidosis), which is caused by variants in the transthyretin (TTR) gene, leads to TTR amyloid deposits in multiple organs and various symptoms such as limb ataxia, muscle weakness, and cardiac failure. Interaction between amyloid proteins and extracellular vesicles (EVs), which are secreted by various cells, is known to promote the clearance of the proteins, but it is unclear whether EVs are involved in the formation and deposition of TTR amyloid in ATTRv amyloidosis. To clarify the relationship between ATTRv amyloidosis and EVs, serum-derived EVs were analyzed.

Fast and high-quality single-pixel imaging.

The imaging quality of the conventional single-pixel-imaging (SPI) technique seriously degrades at a low sampling rate. To tackle this problem, we propose an efficient sampling method and a high-quality real-time image reconstruction strategy: first, different from the conventional simple circular path sampling strategy or variable density random sampling technique, the proposed method samples the Fourier spectrum using the spectrum distribution of the image, that is, sampling the significant spectrum coefficients first, which will help to improve the image quality at a relevantly low sampling rate; second, to handle the long image reconstruction time caused by the iterative algorithm, the sparsity of the image and the alternating direction optimization strategy are combined to ameliorate the reconstruction process in the image gradient space. Compared with the state-of-the-art techniques, the proposed method significantly improves the imaging quality and achieves real-time reconstruction on the time scale of milliseconds.

Estimation of Vibration Characteristics of a Space Manipulator From Air Bearing Supported Test Data.

Space manipulators have attracted much attention due to their implications in on-orbit servicing in recent years. Air bearing based support equipment is widely used for ground test to offset the effect of gravity. However, an air bearing support introduces a new problem caused by additional inertial and mass properties.