Publications by authors named "Zixiao Wan"
Background: Colorectal cancer (CRC) is considered as an age-related disease, and cellular senescence (CS) plays a crucial role in cancer development and progression. Previous studies have shown the role of epigenetic changes in aging and cancer development, but the role of RNA pseudouridine (Ψ) modification in aging and cancer remains to be explored.
Results: Using bulk RNA sequencing, CRC cells with low Ψ writers expression levels have higher CS levels.
Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. The remodeled microenvironment and field cancerization may enable the cancer-specific features in the image of non-cancer regions surrounding cancer, which may provide additional information not available in the cancer region to improve cancer diagnosis.
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- This study explores how radiogenomic analysis can identify imaging biomarkers linked to DNA methylation in gliomas to improve molecular diagnosis and treatment.* -
- Machine learning techniques were applied to analyze MRI features from 146 glioma patients, resulting in models (MoRad) that accurately profile various molecular features, particularly global DNA methylation.* -
- Findings show that global DNA methylation correlates with certain MRI features, histological grades, and various molecular and immunological factors, indicating its potential as a quantitative imaging biomarker.*
Article Synopsis
- Early-onset rectal cancer (LARC) is rising quickly and shows different clinical features and risks compared to late-onset cases, complicating treatment strategies.
- A study analyzed data from the FOWARC trial, focusing on the effects of preoperative radiation on early-onset LARC versus late-onset LARC patients.
- Results show that early-onset LARC patients had worse tumor responses and higher complication risks from radiation, and adding radiation to chemotherapy did not improve their long-term survival compared to chemotherapy alone.