Publications by authors named "Zixia Su"
Bone marrow stromal/stem cells (BMSCs) are generally considered as common progenitors for both osteoblasts and adipocytes in the bone marrow, but show preferential differentiation into adipocytes rather than osteoblasts under aging, thus leading to senile osteoporosis. Accumulated evidences indicate that rejuvenation of BMSCs by autophagic enhancement delays bone aging. Here we synthetized and demonstrated a novel autophagy activator, CXM102 that could induce autophagy in aged BMSCs, resulting in rejuvenation and preferential differentiation into osteoblasts of BMSCs.
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- * This review compiles extensive research, highlighting cinnamaldehyde's role in treating inflammatory diseases, infections, cancer, diabetes, and cardiovascular issues by inhibiting the NF-κB pathway and managing pro-inflammatory responses.
- * There is promising evidence from both preclinical and clinical studies supporting cinnamaldehyde’s potential benefits, but further research is needed to fully understand its mechanisms and ensure safety for developing new therapeutic drugs.
Hypochlorous acid is a reactive oxygen species that is widely present in the body and has been found to exhibit an elevated concentration in tumors. As a result, fluorescent probes for tumor detection have recently gained significant attention. In this study, we designed and synthesized a novel ratiometric fluorescent probe, LW-1, using coumarin as a scaffold, and characterized its spectral properties.
View Article and Find Full Text PDFAquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive system and have important implications for the physiopathology of the gastrointestinal tract as well as other tissues and organs.
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- Recent research highlights the role of thermal transient receptor potential (TRP) ion channels as targets for traditional Chinese medicine (TCM) in managing body temperature and alleviating pain.
- The discovery of TRPV1, a specific TRP channel, underscores their significance, even earning a Nobel Prize for its identification.
- The review identifies 29 TCMs that influence TRP channels, while seeking to explore the unknown molecular mechanisms behind these effects and suggests future research directions.
Context: Markgr. (Gnetaceae) is used to treat rheumatic arthralgia and bruises in the clinic.
Objective: To exam the activity and mechanism of extract (GME) against colon cancer cells SW480.
Objective: Coronavirus Disease 2019 (COVID-19) has been diagnosed as an epidemic disease characterized by cold and dampness pathogens in TCM clinic. Due to many Chinese medicines with different functions were used in the treatment of COVID-19, it is very important to find the law of application of damp-removing traditional Chinese medicine with high frequency application, with view to providing a reference for the use and research of Chinese medicine to further control the pandemic.
Methods: The publicly released diagnosis and treatment programs issued by the National Health Commission and Health Commission of provinces, autonomous regions and municipalities, and Chinese herbs prescription information in these were collected, a database was established, and Excel and Graphpad 8.