Theoretical Study on Intramolecular Hydrogen Bonds of Flavonoid Cocrystals.

This study investigates the role of intramolecular hydrogen bonds in the formation of cocrystals involving flavonoid molecules, focusing on three active pharmaceutical ingredients (APIs): chrysin (CHR), isoliquiritigenin (ISO), and kaempferol (KAE). These APIs form cocrystals with different cocrystal formers (CCFs) through intramolecular hydrogen bonding. We found that disruption of these intramolecular hydrogen bonds leads to decreased stability compared to molecules with intact bonds.

Fusing Ta-doped LiLaZrO grains using nanoscale YO sintering aids for high-performance solid-state lithium batteries.

Solid-state lithium batteries have advantages of high energy density and usage safety and are considered as promising next-generation power sources. Among them, the garnet-type oxide electrolyte has become a widely studied inorganic electrolyte due to its high ionic conductivity and chemical stability. In this paper, nanoscale YO (NYO) particles are introduced as sintering aids for fabricating Ta-doped LiLaZrO (LLZTO) ceramics, and the sintering effects of various NYO ratios on the properties of LLZTO are investigated.

SlNAC3 suppresses cold tolerance in tomatoes by enhancing ethylene biosynthesis.

Low temperature stress poses a significant challenge to the productivity of horticultural crops. The dynamic expression of cold-responsive genes plays a crucial role in plant cold tolerance. While NAC transcription factors have been extensively studied in plant growth and development, their involvement in regulating plant cold tolerance remains poorly understood.

Exploring evolution characteristics of eco-environment quality in the Yangtze River Basin based on remote sensing ecological index.

As an important ecological-economic development area in China, scientific understanding of the spatial and temporal changes in eco-environment quality (EEQ) and its drivers in the Yangtze River Basin (YRB) is crucial for the effective implementation of ecological protection projects in the YRB. To address the lack of large-scale EEQ assessment in the YRB, this paper uses the Google Earth Engine (GEE) platform and the Remote Sensing Ecological Index (RSEI) to investigate the spatial and temporal characteristics of EEQ in the YRB from 2000 to 2020, and to analyze the impact of various factors on the EEQ of the YRB. This study showed that: (1) The overall EEQ of YRB was at the 'good' grade over the past 20 years, showing an increasing trend, with the value changing from 0.

Insights into long-term changes of groundwater levels in the typical region of Zhangjiakou City, China.

Little information is available on the long-term changes of groundwater levels and their associated influencing factors. Zhangjiakou City was chosen as a case to reveal the temporal and spatial dynamics of groundwater level and its driving factors in the long term. Herein, the observation data of groundwater level from 56 wells was investigated from 1981 to 2015, including the collected meteorological data, socio-economic data, and groundwater resource exploitation situation.

Elevated nano-α-FeO enhances arsenic metabolism and dissolved organic carbon release of Microcystis aeruginosa under a phytate environment.

Little information is available on the effects of nano-α-FeO on arsenic (As) metabolism of algae and potential associated carbon (C) storage in As-contaminated water with dissolved organic phosphorus (DOP) as a phosphorus (P) source. In this study, Microcystis aeruginosa (M. aeruginosa) was used to investigate impacts of nano-α-FeO on cell growth and As metabolism of algae under a phytate (PA) environment as well as potential associated C storage.

Psychoactive Comfort Products or Snacks: How Chinese Young Adults Perceive the Potentially Addictive Nature of E-Cigarettes.

The potential health value and pitfalls of e-cigarettes are currently under dispute in the scientific community. Exploring young adult e-cigarette users' perceptions would assist in adding a public dimension of understanding to the literature and in scientific public health decision making. Therefore, in this study, we collected and analyzed data from interviews with young adult ( = 14) e-cigarette users and found that many referred to e-cigarettes as "snacks," indicating that they considered that both their frequency of use and addiction were manageable and that they could stop using e-cigarettes at any time.

Genotypic and phenotypic characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Guangzhou, China.

Background: G6PD deficiency is a common inherited disorder worldwide and has a higher incidence rate in southern China. Many variants of G6PD result from point mutations in the G6PD gene, leading to decreased enzyme activity. This study aimed to analyse the genotypic and phenotypic characteristics of G6PD deficiency in Guangzhou, China.

CUCUME: An RNA methylation database integrating systemic mRNAs signals, GWAS and QTL genetic regulation and epigenetics in different tissues of .

As an internal modification of transcripts, RNA methylation determines RNA fate by changing RNA-protein binding affinity. In plants, RNA methylation is ubiquitous and is involved in all aspects of RNA post-transcriptional regulation. For instance, long-distance mobile RNAs, strongly influenced by their methylation status, play important roles in plant growth, development and environmental adaptation.

The role of shoot-derived RNAs transported to plant root in response to abiotic stresses.

A large number of RNA molecules are transported over long-distance between shoots and roots via phloem in higher plants. Mobile RNA signals are important for plants to tackle abiotic stresses. Shoot-derived mobile RNAs can be involved in the response to different developmental or environmental signals in the root.

The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2.

Cardiac dysfunction has been recognized as a major contributor to mortality in sepsis, which is closely associated with inflammatory reactions. The carboxy terminus of Hsc70-interacting protein (CHIP), a U-box E3 ubiquitin ligase, defends against cardiac injury caused by other factors, but its role in sepsis-induced cardiac dysfunction has yet to be determined. The present study was designed to investigate the effects of CHIP on cardiac dysfunction caused by sepsis and the molecular mechanisms underlying these processes.

Pursuing individualism without feminism: Leisure life and gender politics of young female bar-goers in urban China.

Drawing upon fieldwork data collected among young female bar-goers in China, we examine the gender politics manifested by their leisure activities and argue that these young women are pursuing individualism without feminism. By analyzing the act of bar hopping, we reveal the internal tension of individuation, which urges women to engage in gender labor in order to obtain preferential treatment regarding consumption and a competitive advantage in esthetic femininity. This indicates that the central axis of Chinese women's individualization is a hybrid of neoliberal individuals and essentialist gender roles.

Retinal Vessel Segmentation Based on B-COSFIRE Filters in Fundus Images.

Retinal vessel extraction plays an important role in the diagnosis of several medical pathologies, such as diabetic retinopathy and glaucoma. In this article, we propose an efficient method based on a B-COSFIRE filter to tackle two challenging problems in fundus vessel segmentation: (i) difficulties in improving segmentation performance and time efficiency together and (ii) difficulties in distinguishing the thin vessel from the vessel-like noise. In the proposed method, first, we used contrast limited adaptive histogram equalization (CLAHE) for contrast enhancement, then excerpted region of interest (ROI) by thresholding the luminosity plane of the CIELab version of the original RGB image.

"Returning to Ordinary Citizenship": A Qualitative Study of Chinese PWUD's Self-Management Strategies and Disengagement Model of Identity.

How PWUD (people who use drugs) live under drug governance is an important research question. This study adopts a qualitative research method to explore how PWUD in China self-manage after perceiving the dilemma of incomplete citizenship and the social pressure brought by drug control arrangements. Through analysis of 130 PWUD's files and in-depth interviews with 10 interviewees (from the 24 preliminary interviews), this study found that PWUD developed action strategies of hidden mobility (spatial isolation), disconnection of past experiences (time isolation), instrumental actions, as well as narrative strategies of reframing themselves as ordinary citizens with attempts of reversing identity disadvantages.

Rootstock-scion exchanging mRNAs participate in the pathways of amino acids and fatty acid metabolism in cucumber under early chilling stress.

Cucumber (Cucumis sativus L.) often experiences chilling stress that limits their growth and productivity. Grafting is widely used to improve abiotic stress resistance by alternating a vigorous root system, suggesting there exists systemic signals communication between distant organs.

[The role of SnRK2 in the response to stress, the growth and development of plants].

Sucrose non-fermenting-1-related protein kinase 2 (SnRK2) is a specific Ser/Thr protein kinase in plants. SnRK2 can regulate the expression of downstream genes or transcription factors through phosphorylation of substrates to achieve stress resistance regulation in different tissue parts, and make plants adapt to adverse environment. SnRK2 has a small number of members and a molecular weight of about 40 kDa, and contains a conserved N-terminal kinase domain and a divergent C-terminal regulatory domain, which plays an important role in the expression of enzyme.

Pneumocystis pneumonia in liver transplant recipients.

The clinical course of Pneumocystis pneumonia in liver transplant recipients has not been well investigated. Therefore, we collected and analyzed the clinical, epidemiological, and molecular data from patients with Pneumocystis pneumonia as well as paired controls (Chinese Clinical Trial Registry, ChiCTR2100046028; www.chictr.

Research on a Rice Counting Algorithm Based on an Improved MCNN and a Density Map.

The thousand grain weight is an index of size, fullness and quality in crop seed detection and is an important basis for field yield prediction. To detect the thousand grain weight of rice requires the accurate counting of rice. We collected a total of 5670 images of three different types of rice seeds with different qualities to construct a model.

A novel method for credit scoring based on feature transformation and ensemble model.

Credit scoring is a very critical task for banks and other financial institutions, and it has become an important evaluation metric to distinguish potential defaulting users. In this paper, we propose a credit score prediction method based on feature transformation and ensemble model, which is essentially a cascade approach. The feature transformation process consisting of boosting trees (BT) and auto-encoders (AE) is employed to replace manual feature engineering and to solve the data imbalance problem.

Transcriptomic and Physiological Analysis Reveal That α-Linolenic Acid Biosynthesis Responds to Early Chilling Tolerance in Pumpkin Rootstock Varieties.

Climate changes especially chilling stress affects cucurbit crops during winter seasonal production. Grafting to pumpkin rootstocks is widely used to improve the vigor of cucurbits, especially cucumber ( L.) plants, in the face of chilling stress.

RNA Motifs and Modification Involve in RNA Long-Distance Transport in Plants.

A large number of RNA molecules have been found in the phloem of higher plants, and they can be transported to distant organelles through the phloem. RNA signals are important cues to be evolving in fortification strategies by long-distance transportation when suffering from various physiological challenges. So far, the mechanism of RNA selectively transportation through phloem cells is still in progress.

Optimization of RNA In Situ Hybridization for mRNA Localization Detection in Mature Tissue of Cucumber Seedlings.

Cucumber ( L.) is one of the main vegetable crops in China. The physiological cultivation mechanism and gene function characteristics of cucumber are of great significance to the construction of modern agriculture.