Publications by authors named "Ziwen Yu"

Template-assisted colloidal self-assembly has gained significant attention due to its flexibility and versatility. By precisely controlling the shape of the template, it is possible to achieve custom-designed nanoparticle assemblies. However, a major challenge remains in fabricating these templates over large areas at a low cost.

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The article explores celery-derived extracellular vesicles (CDEVs), characterized by high cellular uptake, low immunogenicity, and high stability, as a therapeutic strategy for antitumor nanomedicines. The methods employed in this study include cell experiments such as co-culture, Western Blot, and flow cytometry. experiments were conducted in C57BL/6 tumor-bearing mice subcutaneously injected with Lewis lung carcinoma (LLC) cells.

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Background: Short-term and long-term adverse events could occur after general anesthesia (GA) and the specific mechanism driving these effects has not yet been well-characterized. In this study, we aimed to evaluate the global effect of GA on DNA methylation in the cell-free DNA (cfDNA) of surgical lung-nodule patients.

Methods: This large retrospective cohort study enrolled 1,006 surgical lung nodule patients (529 pre-anesthesia, and 477 post-anesthesia).

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Article Synopsis
  • Accurate detection of driver gene mutations is key for treating lung cancer, but traditional methods require high-quality tissue samples and can be too slow or unavailable for many patients, especially in low-resource areas.
  • The study developed an AI model called DeepGEM, which uses routine histological slides to predict gene mutations without needing prior annotation or high-quality samples.
  • The model was trained and tested on a large dataset of lung cancer patients across multiple hospitals in China, showing promising results in predicting gene mutations, which was further validated on external and public datasets.
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While the emergence of PM6 : Y6 active layer re-energized the organic photovoltaic community, excessive aggregation of Y6 molecules induced by their strong intermolecular interactions has limited the performance of PM6 : Y6-based organic solar cells (OSCs). Adding 3D multi-arm small-molecule acceptors is an effective strategy to inhibit such aggregation. However, to maximize OSC efficiency, these molecules should also contribute to the electronic processes.

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Article Synopsis
  • Extracellular vesicles (EVs) are small structures released by cells, playing a role in communication between them and showing potential as diagnostic and therapeutic tools.
  • The study presents a new method using in vivo flow cytometry (IVFC) to monitor small EVs (sEVs) in the bloodstream, revealing that the IVFC signal level reflects sEV concentration.
  • Findings indicate that PEGylated sEVs stay longer in circulation and aggregate less than non-PEGylated sEVs, providing insights into how sEVs behave in the body and their potential applications in medicine.
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Background: Respiratory cancer is the leading cause of cancer-related deaths worldwide, but its statistics vary between the East and West. This study aimed to estimate the burdens of tracheal, bronchus, and lung (TBL) cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia, and at regional and national levels.

Methods: This research evaluated the incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) for respiratory tract cancers using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 database.

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To tackle misdiagnosis in lung cancer screening with low-dose computed tomography (LDCT), we aimed to compile a genome atlas for differentiating benign, preinvasive, and invasive lung nodules and characterize their molecular pathogenesis. We collected 432 lung nodule tissue samples from Chinese patients, spanning benign, atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IA). We performed comprehensive sequencing, examining somatic variants, gene expressions, and methylation levels.

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In invasive lung adenocarcinoma (LUAD), patients with micropapillary (MIP) or solid (SOL) components had a significantly poorer prognosis than those with only lepidic (LEP), acinar (ACI) or papillary (PAP) components. It is interesting to explore the genetic features of different histologic subtypes, especially the highly aggressive components. Based on a cohort of 5,933 patients, this study observed that in different tumor size groups, LUAD with MIP/SOL components showed a different prevalence, and patients with ALK alteration or TP53 mutations had a higher probability of developing MIP/SOL components.

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Background: With the aging population, the number of individuals with dementia in China is increasing rapidly. This community-based study aimed to investigate the prevalence and risk factors for dementia and mild cognitive impairment (MCI) among older adults in China.

Methods: In this study, 20,070 individuals aged ≥ 65 were recruited between January 1, 2022, and February 1, 2023, from ten communities in Xiamen City, China.

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With the rapid growth of the economy and industrial technology, vigoroso and stable power distribution networks have gradually been established worldwide. Among these networks, underground cables play a crucial role in the distribution process, determining the overall electrical stability of entire cities. Based on density functional theory, this paper first proposes a TiO particle-doped MoTe monolayer to detect and eliminate these faults and hazardous gases within the underground cableway.

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In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound exhibited high HDAC6 inhibitory activity (IC = 261 nM) and excellent HDAC6 selectivity (SI = 109 for HDAC6 over HDAC3). also showed decent antiproliferative activity with IC of 7.

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Genetic factors play an important role in early-onset Parkinson's disease (EOPD). The genetic spectrum of patients with EOPD varies widely among different ethnicities, with extensive investigations having been performed in Caucasian populations; however, research in Chinese populations remains limited. In this study, we performed multiplex ligation-dependent probe amplification assay and whole-exome sequencing in 15 unrelated Chinese EOPD patients with age of onset before 40 years.

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To reveal the correlation of dynamic serum tumor markers (STMs) and molecular features of epidermal growth factor receptor-mutated (EGFR-mutated) lung cancer during targeted therapy, we retrospectively reviewed 303 lung cancer patients who underwent dynamic STM tests [neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), the soluble fragment of cytokeratin 19 (CYFRA21-1), and squamous cell carcinoma antigen (SCC)] and circulating tumor DNA (ctDNA) testing with a panel covering 168 genes. At baseline, patients with EGFR mutation trended to have abnormal CEA, abnormal CA153, and normal SCC levels. Additionally, patients with Thr790Met (T790M) mutation were more likely to have abnormal CEA levels than patients without T790M mutation.

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Background: Huangkui capsule (HKC) comprises the total flavonoid extract of flowers of (L.) Medicus. This study aimed to explore the effects of HKC on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and LPS-stimulated RAW 264.

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Cancer, as a malignant tumor, seriously endangers human health. The study of cancer diagnosis and therapy has great practical significance. The development of theranostic agents has become a very important research topic.

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The catadioptric panoramic imaging system may provide 360° panoramic imaging by employing the convex surface of a quadric surface with rotational symmetry as the reflector, which effectively compensates for the disadvantages of the narrow field of view in typical camera systems. First, this paper proposes a theodolite-based catadioptric camera image model based on the rotational symmetry of a catadioptric camera mirror, which simplifies the 2D modeling problem to a 1D problem. Simultaneously, the equivalence of the theodolite imaging model and the standard spherical imaging model also is demonstrated in this work.

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A series of 2-phenylthiazole analogues were designed and synthesized as potential histone deacetylase 6 (HDAC6) inhibitors based on compound (an HDAC6/tubulin dual inhibitor discovered by us recently) and CAY10603 (a known HDAC6 inhibitor). Among them, compound was the most potent HDAC6 inhibitor with an IC of 31 nM and excellent HDAC6 selectivity (SI = 338 for HDAC6 over HDAC3). also displayed high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC = 0.

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Background: Several randomized controlled trials have suggested that adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) were associated with prolonged disease-free survival (DFS) in EGFR-mutated NSCLC patients after radical resection, comparing with chemotherapy or placebo. We aimed to compare the effectiveness of different first-generation EGFR-TKIs as adjuvant treatment in real-world setting.

Methods: Early-stage EGFR mutated NSCLC patients who underwent radical resection and treated with first-generation EGFR-TKIs (gefitinib, erlotinib, icotinib) as adjuvant therapy between Feb 2010 and Jan 2019 were retrieved from a prospectively-maintained database in our center.

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Background: The responses of cancer patients to immune checkpoint inhibitors (ICIs) vary in success. CD8+ tumor infiltrating lymphocytes (TILs) play a key role in killing tumor cells. This study aims to evaluate the prognostic role of CD8+ TILs in cancer patients treated with ICIs.

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Familial Alzheimer's disease (FAD) present as a positive family history of cognitive decline, with early onset and an autosomal dominant inheritance pattern. FAD is mainly caused by the mutations in the genes encoding for amyloid precursor protein (), presenilin-1 (), and presenilin-2 (). In the present study, we identified a variant (c.

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Groundwater infiltration into sanitary sewers increases hydraulic loadings of sewage collection systems and threatens wastewater treatment efficiency. However, cost-effective approach to quantify this important process still needs to be improved in order to better manage this common issue. This paper presents a method for determining the origin and amount of groundwater entering the urban sewer system.

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Low Impact Development (LID) is part of a new paradigm in urban water management that aims to decentralize water storage and movement functions within urban watersheds. LID strategies can restore ecosystem functions and reduce runoff loadings to municipal water pollution control facilities (WPCF). This research examines the avoided energy and greenhouse gas (GHG) emissions of select LID strategies using life cycle assessment (LCA) and a stochastic urban watershed model.

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