Integrating polygenic risk scores in the prediction of gestational diabetes risk in China.

Background: Polygenic risk scores (PRS) serve as valuable tools for connecting initial genetic discoveries with clinical applications in disease risk estimation. However, limited studies have explored the association between PRS and gestational diabetes mellitus (GDM), particularly in predicting GDM risk among Chinese populations.

Aim: To evaluate the relationship between PRS and GDM and explore the predictive capability of PRS for GDM risk in a Chinese population.

Broken Global Symmetries and Defect Conformal Manifolds.

Just as exactly marginal operators allow one to deform a conformal field theory along the space of theories known as the conformal manifold, appropriate operators on conformal defects allow for deformations of the defects. When a defect breaks a global symmetry, there is a contact term in the conservation equation with an exactly marginal defect operator. The resulting defect conformal manifold is the symmetry breaking coset, and its Zamolodchikov metric is expressed as the two-point function of the exactly marginal operator.