Curcumin inhibits pancreatic steatosis in mice with a high-fat diet through the YAP/p53 pathway and confirmed through ultrasonic imaging.

Aims: To investigate the mechanism by which curcumin inhibits pancreatic steatosis (PS), and the diagnostic value of ultrasonography in the pancreas of mice with obesity.

Materials And Methods: Male mice were randomly divided into normal chow diet (NC), high-fat diet (HFD), and HFD + 80 mg/kg curcumin groups (HC) and maintained for 12 weeks to induce PS. Weight and fasting blood glucose (FBG) were collected biweekly and oral glucose tolerance test and insulin levels were measured in the final week.

Template-directed self-assembly of porphyrin nanorings through an imine condensation reaction.

Template-directed self-assembly has proven to be an extremely effective method for the precise fabrication of biomacromolecules in natural systems, while artificial template-directed self-assembly systems for the preparation of highly intricate molecules remain a great challenge. In this article, we report the template-directed self-assembly of porphyrin nanorings with different cavity sizes from a tetraaldehyde-derived Zn(ii) porphyrin and a diamine precursor through an imine condensation reaction. Up to 9 or 18 precursor molecules self-assemble together to produce a triporphyrin nanoring and a hexaporphyrin nanoring in one step, with the assistance of a tripyridine or hexapyridine template, respectively.

Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis.

Background: Metastasis remains the leading cause of cancer mortality. The natural product brusatol (Bru) has exhibited promising anticancer activity; however, the target proteins of Bru and the underlying mechanisms in suppressing tumor metastasis remain unclear.

Purpose: We aim to identify the target of Bru and examine its role in suppressing tumor metastasis.

Position-definable coherent microwave pulse train generation in an actively mode-locked optoelectronic oscillator.

An approach to generating position-definable coherent microwave pulse trains is proposed and demonstrated based on an actively mode-locked optoelectronic oscillator (OEO). In this scheme, a low-frequency signal with a customized waveform is employed as the mode-locking signal to periodically manipulate the intracavity gain of the OEO. Once the repetition frequency of the mode-locking signal satisfies the active mode-locking condition, microwave pulses are generated at the time positions corresponding to the gain peaks.

Tinosinenside A inhibits neuroinflammation and protects HT22 cells by suppressing the TLR4/NF-κB/NLRP3 signaling pathway in BV2 cells.

Microglia-mediated neuroinflammation plays a crucial role in Alzheimer's disease (AD). Tinosinenside A (Tis A) is a novel sesquiterpene glycoside isolated from the dried rattan stem of Tinospora sinensis (Lour.) Merr.

Targeting the chemokines in acute graft-versus-host disease.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) constitutes a critical therapeutic approach for patients with malignant hematological disorders. Nevertheless, acute graft-versus-host disease (GVHD), one of the most prevalent complications associated with HSCT, remains a leading contributor to non-relapse mortality. In recent years, there has been an increasing focus on the interplay between chemokines and their receptors in the context of acute GVHD.

Periodic spiking pulse formation in broadband nonlinear optoelectronic oscillator.

An approach to generating periodic spiking pulses in a broadband opto-electronic oscillator (OEO) without external injection is proposed and demonstrated. Through biasing the electro-optic Mach-Zehnder modulator (MZM) in the OEO cavity at its nonlinear working point, spiking pulses are excited by the self-generated chaos under the combined action of the loop filter response time and the nonlinear excitation effect. An interaction force is introduced between pulses.

The association between precuneus cortex thickness and mild behavioral impairment in patients with mild stroke.

The objective of this research was to examine the association between precuneus cortex thickness and mild behavioral impairment (MBI) in patients with mild stroke. Seventy-two patients were evaluated by high-resolution 3 T magnetic resonance and the mild behavioral impairment checklist (MBI-C). To determine the association between precuneus cortex thickness and MBI, we adjusted for demographics, vascular risk factors, and laboratory examination indicators in logistic regression analysis.

Tailoring ORR Activity in Fe-N-C Catalysts through Phosphorus Incorporation.

Atomically dispersed iron and nitrogen co-doped carbon materials (Fe-N-C) represent promising non-precious metal catalysts for the oxygen reduction reaction (ORR), offering potential alternatives to noble metal-based benchmarks. In our study, we investigated the influence of phosphorus doping on the catalytic activity of Fe-N-C. The experimental research demonstrate that the doping of phosphorus significantly enhances the ORR activity.

Temporal dissipative soliton with controllable morphology in a time-delayed coupled optoelectronic oscillator.

A temporal dissipative soliton (TDS) with controllable morphology is demonstrated in a time-delayed coupled optoelectronic oscillator (OEO) driven by two optical carriers with different wavelengths. The morphology of the TDS is controlled by the power difference between the two optical carriers and the delay difference induced by the group-velocity dispersion (GVD) in the OEO loop. When the delay difference is small, the OEO operates in a single-soliton state.

Mitigation effects of plant carbon black on intestinal morphology, inflammation, antioxidant status, and microbiota in piglets challenged with deoxynivalenol.

Introduction: Plant carbon black (PCB) is a new feed additive for zearalenone adsorption in China. However, information regarding whether PCB can effectively absorb deoxynivalenol (DON) is limited.

Methods: To explore this research gap, the present study examined the adsorption effectiveness of DON by PCB using a phosphate buffer, artificial gastric juice, and artificial intestinal juice.

Polymeric bis(triphenylphosphine)iminium chloride as a recyclable catalyst.

Metal-free catalysts have garnered considerable interest as an environmental and economical alternative to precious metal catalysts. Bis(triphenylphosphine)iminium chloride (PPNCl) has emerged as a prominent choice due to its air and thermal stability and broad reactivity, especially in applications where a bulky cation is needed. The high phosphorus content and synthetic effort required for catalyst synthesis increase environmental impact; the recyclability of PPNCl in catalytic processes remains largely unexplored.

Evaluating fetal lung development at various gestational weeks using two-dimensional shear wave elastography.

Background: Noninvasive evaluation of fetal lung development is a critical area of study. Two-dimensional shear-wave elastography (2D-SWE) provides valuable insights into tissue stiffness, potentially correlating with different stages of lung development. This study aims to explore the potential of the 2D-SWE technique for assessing the maturity of fetal lung development.

Intermolecular Assembly of Dual Hydrogen Bonding Regio-Isomers Generates High-Performance AIE Probes.

Regio-isomers are utilized to design innovative AIE luminogens (AIEgens) by regulating molecular aggregation behavior. However, relevant examples are limited, and the underlying mechanism is not fully understood. Herein, a regio-isomer strategy is used to develop AIEgens by precisely regulating the intermolecular interactions in the solid state.

Dense Perovskite Thick Film Enabled by Saturated Solution Filling for Sensitive X-ray Detection and Imaging.

Thick polycrystalline perovskite films synthesized by using solution processes show great potential in X-ray detection applications. However, due to the evaporation of the solvent, many pinholes and defects appear in the thick films, which deteriorate their optoelectronic properties and diminish their X-ray detection performance. Therefore, the preparation of large area and dense perovskite thick films is desired.

Effects of a manganese complex with lysine and glutamic acid on growth performance, manganese deposition, and emission, antioxidant capacity and metacarpal strength in weaned piglets.

The present study sought to assess the effects of manganese complexes with lysine and glutamic acid (Mn-LG) as manganese (Mn) sources on growth performance, trace element deposition, antioxidant capacity, and metacarpal strength in weaned piglets. The study involved 288 healthy Duroc × Landrace × Yorkshire piglets that were weaned at 25 to 28 d of age and weighed 8.66 ± 0.

Effective enrichment and separation of three flavonoids from Ohwia caudata (Thunberg) H. Ohashi using magnetic layered double hydroxide/ZIF-8 composites and pCEC.

In this study, FeO@ZnCr-layered double hydroxide/zeolitic imidazolate frameworks-8 (MLDH/ZIF-8) magnetically functionalized composites were synthesized by co-precipitation and in situ growth based on the advantages of LDHs and ZIF-8 using FeO nanoparticles as a magnetic substrate to obtain adsorbents with excellent performance. Moreover, the composite was used for the efficient enrichment of flavonoids in Chinese herbal medicines. The internal structures and surface properties were characterized by SEM, Fourier transform infrared spectroscopy, X-ray diffraction and so on.

T-cell subsets and cytokines are indicative of neoadjuvant chemoimmunotherapy responses in NSCLC.

Purpose: Neoadjuvant PD-1 blockade combined with chemotherapy is a promising treatment for resectable non-small cell lung cancer (NSCLC), yet the immunological mechanisms contributing to tumor regression and biomarkers corresponding to different pathological responses remain unclear.

Methods: Using dynamic and paired blood samples from NSCLC patients receiving neoadjuvant chemoimmunotherapy, we analyzed the frequencies of CD8 + T-cell and Treg subsets and their dynamic changes during neoadjuvant treatment through flow cytometry. Cytokine profiles and function-related gene expression of CD8 + T cells and Tregs were analyzed through flow cytometry and mRNA-seq.

White matter hyperintensities mediate the association between frailty and cognitive impairment in moyamoya disease.

Objectives: The relationship between cognitive function and frailty in moyamoya disease (MMD) remains unclear, and the underlying mechanism is poorly understood. This study aims to investigate whether white matter hyperintensities (WMHs) mediate the association between frailty and cognitive impairment in MMD.

Methods: Patients with MMD were consecutively enrolled in our study from January 2021 to May 2023.

Composite interfaces of g-CN fragments loaded on a Cu substrate for CO reduction.

Designing an electrocatalyst with high efficiency and product selectivity is always crucial for an electrocatalytic CO reduction reaction (CORR). Inspired by the great progress of two-dimensional (2D) nanomaterials growing on Cu surfaces and their promising CORR catalytic efficiencies at their interfaces, the unique performance of Cu-based 2D materials as high-efficiency and low-cost CORR electrocatalysts has attracted extensive attention. Herein, based on density functional theory (DFT) calculations, we proposed a composite structure of graphitic carbon nitride (g-CN) fragments loaded on a Cu surface to explore the CORR catalytic property of the interface between g-CN and the Cu surface.

Construction of a co-expression network affecting intramuscular fat content and meat color redness based on transcriptome analysis.

Intramuscular fat content (IFC) and meat color are vital indicators of pork quality. A significant positive correlation between IFC and redness of meat color (CIE value) indicates that these two traits are likely to be regulated by shared molecular pathways.To identify candidate genes, hub genes, and signaling pathways that regulate these two traits, we measured the IFC and CIE value in 147 hybrid pigs, and selected individuls with extreme phenotypes for transcriptome analysis.

Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities.

Background: The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising. This study aims to analyze clinicopathological features, gene abnormalities, and prognostic outcomes in individuals diagnosed with PLC-PHM MPC.

Methods: A retrospective analysis included 89 patients diagnosed with PLC-PHM MPC at the Respiratory or Hematology Departments of Ruijin Hospital from 2003 to 2022 (a total of 842,047 people).