RELMβ sets the threshold for microbiome-dependent oral tolerance.

Tolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule β (RELMβ) is a critical regulator of oral tolerance.

High-efficiency Pb removal by hydroxy-sodalite for point-of-use drinking water purification.

The development of cost-effective point-of-use (POU) devices that effectively remove lead (Pb) from drinking water is imperative in mitigating the threat of Pb contamination to public health in underdeveloped regions. Herein, we have successfully transformed inexpensive natural kaolinite as hydroxy-sodalite (HySOD) via a simple hydrothermal process, achieving an impressive yield of 91.5 %.

High cellular plasticity state of medulloblastoma local recurrence and distant dissemination.

Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity and genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and spatial transcriptomics profiles and identified distinct cellular populations in SHH (sonic hedgehog) and Group_3 subgroups, with varying proportions in local recurrence or dissemination. Local recurrence showed higher cycling tumor cell enrichment, whereas disseminated lesions had a relatively notable presence of differentiated subsets.

Nonlinear relationship between physical environment risks, investor attentions, and financial systemic risks: Evidence from mLSTM-CoVaR networks.

How do physical environment risks affect financial market systemic risk? We use remoting data to measure physical environment risks and select 26 banks across 12 EU countries. We extend the CoVaR framework with the quantile-mLSTM algorithm, obtaining time-varying CoVaRs. We then use time-varying partial derivatives to calculate the banks' tail risk spillover effects.

Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response.

Radiotherapy is an integral component in the treatment of many types of cancer, with approximately half of cancer patients receiving radiotherapy. Systemic therapy applies pressure that can select for resistant tumor subpopulations, underscoring the importance of understanding how radiation impacts tumor evolution to improve treatment outcomes. We integrated temporal genomic profiling of 120 spatially distinct tumor regions from 20 patients with undifferentiated pleomorphic sarcomas (UPS), longitudinal circulating tumor DNA (ctDNA) analysis, and evolutionary biology computational pipelines to study UPS evolution during tumorigenesis and in response to radiotherapy.

Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8 T cells and alleviating thymus injury.

Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.

Exploring the effect of carbon nanoparticle tracing technique on five-year overall survival and disease-free survival in patients undergoing radical surgery for colorectal cancer: a retrospective study.

Background: To investigate the effect of preoperative carbon nanoparticle tracing technique via colonoscopy on the five-year overall survival and disease-free survival rates in patients undergoing radical resection for colorectal cancer.

Methods: A retrospective cohort study was conducted to collect data from patients diagnosed with colorectal cancer who underwent radical resection with complete postoperative pathological information at the First Affiliated Hospital of Chongqing Medical University from March 2013 to February 2017. Patients with multiple primary cancers were excluded, resulting in 2,237 eligible patients in the study.

Insights into hepatotoxicity of fluorinated liquid crystal monomer 1-ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) benzene (EDPrB) in adult zebrafish at environmentally relevant concentrations: Metabolic disorder and stress response.

Fluorinated liquid crystal monomers (FLCMs) are widely employed in liquid crystal display (LCD) panels. As emerging environmental contaminants with persistent, bioaccumulative, and toxic properties, FLCMs were proven to accumulate in liver, raising great concern regarding potential hepatotoxicity. 1-Ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) benzene (EDPrB), as one representative FLCM, was chosen to investigate the hepatotoxicity in adult zebrafish (Danio rerio) at environmentally relevant concentrations (1, 10, and 100 μg/L) with long-term exposure (21 days).

Embodied neuromorphic synergy for lighting-robust machine vision to see in extreme bright.

Proper exposure settings are crucial for modern machine vision cameras to accurately convert light into clear images. However, traditional auto-exposure solutions are vulnerable to illumination changes, splitting the continuous acquisition of unsaturated images, which significantly degrades the overall performance of underlying intelligent systems. Here we present the neuromorphic exposure control (NEC) system.

Exploring pathways to digital transformation: fsQCA analysis based on the AMO framework.

In recent years, China has significantly increased its global competitiveness in digital technologies, emphasizing the importance of the digital economy during the high-quality development stage. The question of how firms in traditional industries can achieve digital transformation, which is critical for participating in the digital economy, is still understudied. Using the ability-motivation-opportunity (AMO) framework, this research developed a model and identified six factors' ability, motivation, and opportunity dimensions.

Enhanced Pb immobilization by CaO/MgO-modified soybean residue (okara) in phosphate mining wasteland soil: Mechanism and microbial community structure.

Lead (Pb) contamination is an inevitable consequence of phosphate mining, necessitating the development of effective remediation strategies. This study investigated the use of CaO/MgO-modified okara (CMS) as an eco-friendly approach to remediate Pb-contaminated soils from phosphate mining wastelands. In the present study, following 30 d of CMS application, the exchangeable Pb content was significantly decreased to 10.

A curcumin-based HDACs inhibitor for targeted sonodynamic therapy of breast cancer.

Histone Deacetylases (HDACs) have emerged as key therapeutic targets in cancer treatment. In this study, we designed CURSAHA, a multifunctional anticancer agent, through the pharmacophore fusion of Vorinostat and curcumin. CURSAHA demonstrates broad-spectrum inhibitory activity against HDACs, effectively suppressing tumor cells with overexpressed HDACs.

Histone lactylation-mediated overexpression of RASD2 promotes endometriosis progression via upregulating the SUMOylation of CTPS1.

Histone lactylation is crucial in a variety of physiopathological processes; however, the function and mechanism of histone lactylation in endometriosis remain poorly understood. Therefore, the objective of this investigation was to illuminate the function and mechanism of histone lactylation in endometriosis. Immunohistochemistry was used to investigate the expression of histone lactylation.

MDIG in Breast Cancer Progression and Metastasis.

Breast cancer is the most diagnosed cancer among women worldwide, and metastasis remains the major cause of breast cancer-related mortality and is associated with poor patient outcomes. Among breast cancers, triple-negative breast cancers have the worst prognosis owing to their highly aggressive and metastasizing attributes and hence have limited therapeutic options. Here, we have presented our research on an environmentally regulated gene named mdig and its role in the pathogenesis of breast cancer and metastasis.

Forecast of NOx Emissions for a 660MW Coal-Fired Boiler with Multilayered Gradient Boosting Decision Tree Considering Multiple Operating Modes.

Nitrogen oxides (NOx) are among the primary pollutants emitted by coal-fired power plants. Accurate prediction of NOx concentrations at the boiler outlet is crucial for optimizing unit control and reducing emissions. This study introduces a data-driven NOx emissions prediction methodology based on a multilayered Gradient Boosting Decision Tree (mGBDT) framework.

Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations.

Small molecules that possess the ability to regulate the interactions between Son of Sevenless 1 (SOS1) and Kristen rat sarcoma (KRAS) offer immense potential in the realm of cancer therapy. In this study, we present a novel series of SOS1 inhibitors featuring a tricyclic quinazoline scaffold. Notably, we have identified compound 8d, which demonstrates the highest potency with an IC value of 5.

Antimicrobial Susceptibility Testing-Guided Eradication Therapy in the Southeast Region of China: A Retrospective Study.

Background And Aim: Antibiotic resistance of is increasing worldwide, lowering its efficacy in eradication therapy and posing a serious threat to human health. This study evaluated resistance to antibiotics in the southeast region of China and explored factors related to eradication failure guided by antimicrobial susceptibility testing (AST).

Methods: In this retrospective study, patients who tested positive underwent gastroscopy, and infection was confirmed by histological staining and culture.

Comparative analysis of manual vs. mechanical suturing techniques in esophagectomy: A propensity score‑matched study of long‑term outcomes.

Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a major health concern worldwide, particularly in China. Surgical resection is still considered the primary curative treatment for this disease. However, the effect of different surgical methods-traditional hand-sewn anastomosis and modern mechanical anastomosis-remains controversial.

Computer tomography-based radiomics combined with machine learning for predicting the time since onset of epidural hematoma.

Estimation of the age of epidural hematoma (EDH) is a challenge in clinical forensic medicine, and this issue has yet to be conclusively resolved. The advantages of objectivity and non-invasiveness make computing tomography (CT) imaging an potential diagnostic method for EDH in living individuals. Recently, radiomics, the extraction hidden information from medical images, has emerged as a promising method for constructing predictive models.

Optimization of ecological network to improve water conservation services in the Nianchu River Basin.

Against the backdrop of water resource depletion in the Qinghai-Tibet Plateau, water conservation services (WCS) have emerged as critical ecosystem services warranting attention. Adjusting the ecological network (EN) structure and optimizing topological relationships among landscape elements are instrumental in facilitating ecological processes, constituting an effective approach for enhancing WCS. We employed the Integrated Valuation of Ecosystem Services and Tradeoffs model to simulate the WCS value in the Nianchu River Basin and used the Minimum Cumulative Resistance model in combination with the Linkage Mapper to construct an EN.

BPA-free? Exploring the reproductive toxicity of BPA substitutes BPS and BPF on endometrial decidualization.

Bisphenol A (BPA) exposure is linked to multiple adverse health outcomes, prompting the rise of "BPA-free" products. However, substitutes like Bisphenol S (BPS) and Bisphenol F (BPF) are equally prevalent, with detection frequencies and concentrations rivaling BPA. Our research previously identified BPA as an endocrine disruptor affecting reproductive and developmental systems.

Haplotype-resolved genome assembly of poplar line NL895 provides a valuable tree genomic resource.

Poplar line NL895 can potentially become a model plant for poplar study as it is a widely cultivated elite line. However, the lack of genome resources hindered the use of NL895 as the major plant material in poplar. In this study, we provided a high-quality genome assembly for poplar line NL895 with PacBio single molecule real-time (SMRT) sequencing and High-throughput chromosome conformation capture (Hi-C) technology.