Population genetic structure of Culex tritaeniorhynchus in different types of climatic zones in China.

Background: Culex tritaeniorhynchus is widely distributed in China, from Hainan Island in the south to Heilongjiang in the north, covering tropical, subtropical, and temperate climate zones. Culex tritaeniorhynchus carries 19 types of arboviruses. It is the main vector of the Japanese encephalitis virus (JEV), posing a serious threat to human health.

The Performance of the Two-Seeded GdBCO Superconductor Bulk with the Buffer by the Modified TSMG Method.

The multiseeding technique is a method to grow large-sized REBaCuO (REBCO, where is a rare earth element) high temperature superconducting bulks. However, due to the existence of grain boundaries between seed crystals, the superconducting properties of bulks are not always better than those of single grain bulks. In order to improve the superconducting properties caused by grain boundaries, we introduced buffer layers with a diameter of 6 mm in the growth of GdBCO bulks.

Evaluation of the evolutionary genetics and population structure of Culex pipiens pallens in Shandong province, China based on knockdown resistance (kdr) mutations and the mtDNA-COI gene.

Background: Mosquitoes are important vectors for a range of diseases, contributing to high rates of morbidity and mortality in the human population. Culex pipiens pallens is dominant species of Culex mosquito in northern China and a major vector for both West Nile virus and Bancroftian filariasis. Insecticide application were largely applied to control the mosquito-mediated spread of these diseases, contributing to increasing rates of resistance in the mosquito population.

Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.

BRAF mutations have been found in gliomas which exhibit abnormal electrophysiological activities, implying their potential links with the ion channel functions. In this study, we identified the Drosophila potassium channel, Slowpoke (Slo), the ortholog of human KCNMA1, as a critical factor involved in dRaf glioma progression. Slo was upregulated in dRaf glioma.

Interactions between the gut micro-community and transcriptome of Culex pipiens pallens under low-temperature stress.

Background: Culex pipiens pallens (Diptera: Culicidae) can survive at low temperature for long periods. Understanding the effects of low-temperature stress on the gut microflora and gene expression levels in Cx. pipiens pallens, as well as their correlation, will contribute to the study of the overwintering mechanism of Cx.

METTL14 Regulates Intestine Cellular Senescence through mA Modification of Lamin B Receptor.

N-6-Methyladenosine (mA) modification is involved in multiple biological processes including aging. However, the regulation of mA methyltransferase-like 14 (METTL14) in aging remains unclear. Here, we revealed that the level of mA modification and the expression of METTL14 were particularly decreased in the intestine of aged mice as compared to young mice.

Phosphatase of Regenerating Liver-1 Regulates Wing Vein Formation through TGF-β Pathway in .

Background: Phosphatase of Regenerating Liver-1 (PRL-1) is the only homolog of the mammalian PRLs with which it shares high sequence and structural similarities. Whilst PRLs are most notable for their high expression in malignant cancers and related promotion of cancer progression, the specific biological functions of the PRLs remain largely elusive.

Methods: Here, using a gain-of-function approach, we found that PRL-1 functions during wing vein development in ().

Flux Pinning Properties of Single-Grain Bulk GdBCO Superconductors Processed by Different Thicknesses of Y123 Liquid Source.

The performance of critical current density of GdBaCuO (GdBCO or Gd123) superconductor bulk has an important influence on its practical applications. In this work, four single-domain GdBCO superconductor bulks were successfully processed by the modified top-seeded melt-texture growth method. The addition of a YBaCuO (Y123) liquid source with different thicknesses, 0 mm (S0), 3 mm (S3), 5 mm (S5), 7 mm (S7), was introduced to study the influence on the superconducting properties.

A motor neuron protective role of miR-969 mediated by the transcription factor kay.

Maintenance of motor neuron structure and function is crucial in development and motor behaviour. However, the genetic regulatory mechanism of motor neuron function remains less well understood. In the present study, we identify a novel neuroprotective role of the microRNA miR-969 in motor neurons.