Dynamic risk prediction models for different subtypes of hypertensive disorders in pregnancy.

Background: Hypertensive disorders in pregnancy (HDP) are diseases that coexist with pregnancy and hypertension. The pathogenesis of this disease is complex, and different physiological and pathological states can develop different subtypes of HDP.

Objective: To investigate the predictive effects of different variable selection and modeling methods on four HDP subtypes: gestational hypertension, early-onset preeclampsia, late-onset preeclampsia, and chronic hypertension complicated with preeclampsia.

Targeted delivery of ZNF416 siRNA-loaded liposomes attenuates experimental pulmonary fibrosis.

Background: Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that matrix stiffness is essential in promoting fibroblast activation and profibrotic changes. Here, we investigated the expression and function of matrix stiffness-regulated ZNF416 in pulmonary fibrotic lung fibroblasts.

Quantized H filtering for networked persistent dwell-time switched piecewise-affine systems.

In this study, the problem of quantized H filtering is addressed for networked switched piecewise-affine systems, in which the switching mechanism obeys the persistent dwell-time constraint. To process the measurement output and schedule the transmission sequence for alleviating the burden of the limited communication channel, a logarithmic quantizer is employed, which can further improve the bandwidth utilization in networked switched systems. On the basis of state-space division, the objective is to design a mode-dependent and region-dependent filter that ensuresthe filtering error system is globally uniformly exponentially stable and meets an H performance.

Genome-wide identification and expression analysis of gene family reveal their involvement in hormone response and abiotic stresses in .

promoter-binding-protein (SBP)-box family proteins are a class of plant-specific transcription factors, and widely regulate the development of floral and leaf morphology in plant growth and involve in environment and hormone signal response. In this study, we isolated and identified 21 non-redundant genes in with bioinformatics analysis. Sequence alignments of 21 CnSBP proteins discovered a highly conserved SBP domain including two zinc finger-like structures and a nuclear localization signal region.

The pathogenesis, diagnosis, prevention, and treatment of CAR-T cell therapy-related adverse reactions.

Chimeric antigen receptor (CAR)-T cell therapy is effective in the treatment of refractory/relapsed (r/r) hematological malignancies (r/r B-cell lymphoblastic leukemia, B-cell lymphoma, and multiple myeloma). In addition, it is being explored as a treatment option for solid tumors. As of 31 March 2022, seven CAR-T therapies for hematological malignancies have been approved worldwide.

3.76-Gbps yellow-light visible light communication system over 1.2 m free space transmission utilizing a Si-substrate LED and a cascaded pre-equalizer network.

Recently, visible light communication (VLC) has emerged as a promising communication method in 6G. To achieve 6G high-speed transmission, wavelength division multiplexing (WDM) based VLC systems are a highly promising candidate. However, the "yellow and green gap" greatly limits the yellow light efficiency of InGaN-based LEDs and also restricts the transmission rate of yellow LEDs.

Fast hyperspectral single-pixel imaging via frequency-division multiplexed illumination.

Hyperspectral imaging that detects 3D spectra-spatial information has been used in a wide range of applications. Among reported techniques, multiplexed spectral imaging with a single-pixel detector provides as a photon-efficient and low-cost implementation; however, the previous spectral modulation schemes are mostly complicated and sacrifice the imaging speed. Here, we propose a fast and compact hyperspectral single-pixel imaging technique based on programmable chromatic illumination.

Dynamic prediction model of fetal growth restriction based on support vector machine and logistic regression algorithm.

Background: This study analyzed the influencing factors of fetal growth restriction (FGR), and selected epidemiological and fetal parameters as risk factors for FGR.

Objective: To establish a dynamic prediction model of FGR.

Methods: This study used two methods, support vector machine (SVM) and multivariate logistic regression, to establish the prediction model of FGR at different gestational weeks.

Giant Enhancement of Second-Harmonic Generation in Hybrid Metasurface Coupled MoS with Fano-Resonance Effect.

Plasmonic nanostructures have been regarded as potential candidates for boosting the nonlinear up-conversion rate at the nanoscale level due to their strong near-field enhancement and inherent high design freedom. Here, we design a hybrid metasurface to realize the moderate interaction of Fano resonance and create the dual-resonant mode-matching condition to facilitate the nonlinear process of second harmonic generation (SHG). The hybrid metasurface presents dipolar and octupolar plasmonic modes near the fundamental and doubled-frequency wavelengths, respectively, further utilized to enhance the SHG of low-dimensional MoS semiconductors.

Enzymatic modification of D-mannose alleviates DSS-induced colonic inflammation in mice through macrophage polarization mediated by PPARγ.

As a dietary supplement, supraphysiological levels of D-mannose have been proven to attenuate colitis administration of 20% (w/v) D-mannose given in drinking water or by oral gavage. However, we observed that a lower dosage of 2% (w/v) D-mannose had no significant beneficial effect on colitis. Herein, enzymatic modification of mannose (phosphatidylmannoside, PtdMan) phospholipase D catalyzed transphosphatidylation is proposed as a way to enhance the modulatory effect of mannose on colitis.

Liposomal UHRF1 siRNA shows lung fibrosis treatment potential through regulation of fibroblast activation.

Pulmonary fibrosis is a chronic and progressive interstitial lung disease associated with the decay of pulmonary function, which leads to a fatal outcome. As an essential epigenetic regulator of DNA methylation, the involvement of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) in fibroblast activation remains largely undefined in pulmonary fibrosis. In the present study, we found that TGF-β1-mediated upregulation of UHRF1 repressed beclin 1 via methylated induction of its promoter, which finally resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.

Does Hyponatremia Affect the Short-Term Outcomes of Colorectal Cancer Surgery: A Propensity Score Matching Analysis.

Purpose: The purpose of the current study is to analyze whether preoperative hyponatremia affected the short-term outcomes of colorectal cancer (CRC) surgery.

Methods: This retrospective study was conducted in a single clinical center where we enrolled patients who underwent primary CRC surgery from January 2011 to December 2021. The short-term outcomes were compared between the hyponatremia group and the normal sodium group using propensity score matching (PSM) analysis.

The 5'-end motif of Senecavirus A cDNA clone is genetically modified in 36 different ways for uncovering profiles of virus recovery.

Senecavirus A (SVA) is an emerging picornavirus. Its genome is one positive-sense, single-stranded RNA. The viral protein (VPg) is covalently linked to the extreme 5' end of the SVA genome.

Saving 80% Polypropylene in Facemasks by Laser-Assisted Melt-Blown Nanofibers.

The ongoing coronavirus (COVID-19) pandemic requires enormous production of facemasks and related personal protection materials, thereby increasing the amount of nondegradable plastic waste. The core material for facemasks is melt-blown polypropylene (PP) fiber. Each disposable facemask consumes ∼0.

Potential application of TurboID-based proximity labeling in studying the protein interaction network in plant response to abiotic stress.

Abiotic stresses are major environmental conditions that reduce plant growth, productivity and quality. Protein-protein interaction (PPI) approaches can be used to screen stress-responsive proteins and reveal the mechanisms of protein response to various abiotic stresses. Biotin-based proximity labeling (PL) is a recently developed technique to label proximal proteins of a target protein.

Crystal idioblasts are involved in the anther dehiscence of Nicotiana tabacum.

In Nicotiana tabacum, the degeneration of connective tissue and stomium tissue (the stomium and circular cell cluster [CCC]) is essential for anther dehiscence. Both connective cells and CCC cells are crystal idioblasts, and these cells will undergo degeneration after accumulating calcium oxalate (CaOx) crystals. However, detailed data concerning this process are minimal.

Analysis of the functional gene of degrading BDE-47 by Acinetobacter pittii GB-2 based on transcriptome sequencing.

2,2',4,4'-tetrabrominated diphenyl ether (BDE-47) is one of the most widely distributed PBDEs. BDE-47 is also the most abundant in organisms and the most toxic to humans and animals. Herein, we have studied the pathway of BDE-47 degradation and gene involvement in Acinetobacter pittii GB-2.

A Weakly Supervised Brain Tumor Segmentation Strategy Based on Multi-level Sub-category and Membership Matrix.

Background: Using a classification network to generate class activation mapping (CAM) is a mainstream method for weakly supervised semantic segmentation. However, for brain tumor images, CAM cannot fit the boundary of the tumor well.

Objective: To improve the performance of brain tumor CAM, we propose a weakly supervised learning strategy based on a multi-level sub-category and membership matrix.

Preparation, characterization, and osteogenic activity mechanism of casein phosphopeptide-calcium chelate.

Casein phosphopeptides (CPPs) are good at calcium-binding and intestinal calcium absorption, but there are few studies on the osteogenic activity of CPPs. In this study, the preparation of casein phosphopeptide calcium chelate (CPP-Ca) was optimized on the basis of previous studies, and its peptide-calcium chelating activity was characterized. Subsequently, the effects of CPP-Ca on the proliferation, differentiation, and mineralization of MC3T3-E1 cells were studied, and the differentiation mechanism of CPP-Ca on MC3T3-E1 cells was further elucidated by RNA sequencing (RNA-seq).

Robust humoral and cellular immune responses in long-term convalescent COVID-19 individuals following one-dose SARS-CoV-2 inactivated vaccination.

COVID-19, caused by SARS-CoV-2, has resulted in hundreds of millions of infections and millions of deaths worldwide. Preliminary results exhibited excellent efficacy of SARS-CoV-2 vaccine in preventing hospitalization and severe disease. However, data on inactivated vaccine-induced immune responses of naturally infected patients are limited.

Organ-on-a-chip: A new tool for in vitro research.

Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and simulate the physiology of tissues and organs. It will become an increasingly important platform for in vitro drug development and screening. Most importantly, organ-on-a-chip technology, incorporating 3D cell cultures, overcomes the traditional drawbacks of 2D (flat) cell-culture technology in vitro and in vivo animal trials, neither of which generate completely reliable results when it comes to the actual human subject.

Duck CD8 T Cell Response to H5N1 Highly Pathogenic Avian Influenza Virus Infection In Vivo and In Vitro.

Domestic ducks are the important host for H5N1 highly pathogenic avian influenza virus (HPAIV) infection and epidemiology, but little is known about the duck T cell response to H5N1 AIV infection. In infection experiments of mallard ducks, we detected significantly increased CD8 cells and augmented expression of cytotoxicity-associated genes, including granzyme A and IFN-γ, in PBMCs from 5 to 9 d postinfection when the virus shedding was clearly decreased, which suggested the importance of the duck cytotoxic T cell response in eliminating H5N1 infection in vivo. Intriguingly, we found that a CD8 population of PBMCs was clearly upregulated in infected ducks from 7 to 9 d postinfection compared with uninfected ducks.

Preoperative hypokalemia can increase complications after colorectal cancer surgery: a propensity score matching analysis.

Background: Whether hypokalemia can affect the short-term outcomes of CRC patients after radical surgery remains unclear. The purpose of this study was to investigate the impact of preoperative hypokalemia on the short-term outcomes for colorectal cancer (CRC) patients who underwent radical CRC surgery using propensity score matching (PSM).

Methods: We retrospectively enrolled consecutive CRC patients from Jan 2011 to Dec 2021 in a single-center hospital.

Genome Functional Analysis of the Psychrotrophic Lignin-Degrading Bacterium sp. C2 and the Role of DyP in Catalyzing Lignin Degradation.

In the cold regions of China, lignin-rich corn straw accumulates at high levels due to low temperatures. The application of psychrotrophic lignin-degrading bacteria should be an effective means of overcoming the low-temperature limit for lignin degradation and promoting the utilization of corn straw. However, this application is limited by the lack of suitable strains for decomposition of lignin; furthermore, the metabolic mechanism of psychrotrophic lignin-degrading bacteria is unclear.