Publications by authors named "Zivile Zemeckiene"
Article Synopsis
- Distinct SARS-CoV-2 lineage B.1.620 was identified in Lithuania, featuring multiple mutations in the spike protein commonly found in concerning variants like E484K and S477N.
- The study highlights the lineage's potential resistance to neutralizing antibodies and documents local instances of transmission in Europe, particularly in Lithuania.
- Evidence suggests that B.1.620 likely originated in Central Africa, supported by advanced phylogeographic methods and travel history data from infected individuals.
Unlabelled: IL-33 is a recently discovered cytokine which plays an important role in asthma pathogenesis.
Aim: To evaluate serum IL-33 in patients with asthma and healthy controls, and to evaluate the association of IL-33 with different asthma phenotypes.
Methods: Patients with asthma (n = 115) and healthy subjects (n = 85) were included in the study.
PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations.
View Article and Find Full Text PDFObjective: To investigate polymorphisms of proteasomal genes PSMA6 (rs1048990 and rs2277460), PSMC6 (rs2295826 and rs2295827) and PSMA3 (rs2348071) in Lithuanian patients with asthma.
Methods: One-hundred forty-six asthma patients and 150 control subjects were studied. DNA was extracted from peripheral blood samples.
A proteasome, a multicatalytic protein complex, is a central particle of the ubiquitin-proteasome proteolytic pathway in all eukaryotic cells. Through the degradation of most intracellular proteins, proteasomes play a significant role in cell processes, such as cell cycle and division, posttranslational protein quality control, cell signaling, and apoptosis. Therefore, the ubiquitin-proteasome system is necessary to ensure the normal functioning of cells and an organism.
View Article and Find Full Text PDF