According to active aging theory, self-management plays a pivotal role for well-being of older adults as they navigate the aging process. The current quasi-experimental study, employing a between-within design, examines the impact of guided group physical training on changes in self-management and its subsequent effect on quality of life among a sample of independently living old adults. We assessed balance, strength, mobility, self-management, and quality of life were among 149 older adults (123 females, 26 males), mean age = 77.
View Article and Find Full Text PDFHere we propose a not pupil-dependent microsaccades tracking technique and a novel detection method. We present a proof of concept for detecting microsaccades using a non-contact laser-based photonic system recording and processing the temporal changes of speckle patterns scattered from an eye sclera. The data, simultaneously recorded by the speckle-based tracker (SBT) and the video-based eye tracker (Eyelink), was analyzed by the frequently used detection method of Engbert and Kliegl (E&K) and by advanced machine learning detection (MLD) techniques.
View Article and Find Full Text PDFProtein aggregation is a hallmark of age-related neurodegeneration. Yet, aggregation during normal aging and in tissues other than the brain is poorly understood. Here, we leverage the African turquoise killifish to systematically profile protein aggregates in seven tissues of an aging vertebrate.
View Article and Find Full Text PDFProtein aggregation, which can sometimes spread in a prion-like manner, is a hallmark of neurodegenerative diseases. However, whether prion-like aggregates form during normal brain aging remains unknown. Here, we use quantitative proteomics in the African turquoise killifish to identify protein aggregates that accumulate in old vertebrate brains.
View Article and Find Full Text PDFSchizophrenia (Heidelb)
May 2024
A variety of studies have suggested that at least some children with autism spectrum disorder (ASD) view the world differently. Differences in gaze patterns as measured by eye tracking have been demonstrated during visual exploration of images and natural viewing of movies with social content. Here we analyzed the temporal randomness of saccades and blinks during natural viewing of movies, inspired by a recent measure of "randomness" applied to micro-movements of the hand and head in ASD (Torres et al.
View Article and Find Full Text PDFBackground: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. It is associated with significant itch and impaired quality of life. Systemic treatments are efficient but associated with side effects.
View Article and Find Full Text PDFCell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how size influences cell physiology. Increasing cell size was recently shown to remodel the proteomes of cultured human cells, demonstrating that large and small cells of the same type can be biochemically different. Here, we corroborate these results in mouse hepatocytes and extend our analysis using yeast.
View Article and Find Full Text PDFPsychosis is diagnosed based on disruptions in the structure and use of language, including reduced syntactic complexity, derailment, and tangentiality. With the development of computational analysis, natural language processing (NLP) techniques are used in many areas of life to make evaluations and inferences regarding people's thoughts, feelings and behavior. The present study explores morphological characteristic of schizophrenia inpatients using NLP.
View Article and Find Full Text PDFPhilos Trans R Soc Lond B Biol Sci
June 2021
Protein aggregation, particularly in its prion-like form, has long been thought to be detrimental. However, recent studies have identified multiple instances where protein aggregation is important for normal physiological functions. Combining mass spectrometry and cell biological approaches, we developed a strategy for the identification of protein aggregates in cell lysates.
View Article and Find Full Text PDFOur eyes are never still, but tend to "freeze" in response to stimulus onset. This effect is termed "oculomotor inhibition" (OMI); its magnitude and time course depend on the stimulus parameters, attention, and expectation. We previously showed that the time course and duration of microsaccade and spontaneous eye-blink inhibition provide an involuntary measure of low-level visual properties such as contrast sensitivity during fixation.
View Article and Find Full Text PDFObservation of the romantic lives of the majority of young people shows that they might move between transitory and inconsistent states, being in and out of a relationship. The present study aims to better understand the meaning of these fluctuations. For this purpose, and employing a multi-method design, 144 Israeli adolescents (59.
View Article and Find Full Text PDFAdolescent sexual behavior was examined within a health perspective. Assuming a developmental perspective, the current study investigated the associations between sexual behavior in either stable relationships or in casual encounters, and the quality of romantic relationships and affect 4 years later. Data were collected from 144 Israeli adolescents aged 16-18 years (mean age 16.
View Article and Find Full Text PDFStudies suggest that married people frequently engage in intimate relationships with people other than their spouses, and the literature has extensively examined motives for doing so. However, less is known about what factors prevent spouses from engaging in extramarital sex. While investment theory, interdependence theory, and moral theories offer insights into this question, they have not been subject to much empirical research.
View Article and Find Full Text PDFHeparin is known to have anti-inflammatory effects, yet the mechanisms are not completely understood. In this study, we tested the hypothesis that heparin has a direct effect on activated polymorphonuclear leukocytes (PMNLs), changing their activation state, and can explain its anti-inflammatory effect. To test our hypothesis, we designed both in vitro and ex vivo studies to elucidate the mechanism by which heparin modulates PMNL functions and therefore the inflammatory response.
View Article and Find Full Text PDFStudies of correlations between general internet use and psychological well-being have shown mixed results. The present study aimed to elucidate the relationship between Facebook use and psychological well-being, with mental resilience expected to moderate the relationship. Two hundred Israeli adolescents and young adults completed questionnaires assessing their Facebook use, mental resilience, and psychological well-being.
View Article and Find Full Text PDFUbiquitin-binding domains (UBDs) differentially recognize ubiquitin (ub) modifications. Some of them specifically bind mono-ub, as has been shown for the CUE domain. Interestingly, so far no significant ubiquitin binding has been observed for the CUE domain of yeast Cue1p.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
September 2012
Purpose: Early assessment of tumor response to therapy is vital for treatment optimization for the individual cancer patient. Induction of apoptosis is an early and nearly universal effect of anticancer therapies. The purpose of this study was to assess the performance of (18)F-ML-10, a novel PET radiotracer for apoptosis, as a tool for the early detection of response of brain metastases to whole-brain radiation therapy (WBRT).
View Article and Find Full Text PDFJ Neural Transm (Vienna)
November 2012
Parkinson's disease (PD) exacts a physical and emotional toll on both patients and family. The aim of this study was to compare patient and caregiver perceptions of the social consequences of basic symptoms of PD and levodopa-induced dyskinesias. Forty patients with PD and dyskinesias and 35 of their caregivers completed a self-report questionnaire on the impact of PD and dyskinesias on their feelings of security and embarrassment and participation in family/social events, and indicated their preference for the "on" (with dyskinesias) or the "off" (without dyskinesias) state.
View Article and Find Full Text PDFThe present study analyzes the differential contribution of a familial or social focus in imaginative ideation (the personal fable and imagined audience mental constructs) to the separation-individuation process of firstborn, middleborn, and lastborn children. A total of 160 young adults were divided into 3 groups by birth order. Participants' separation-individuation process was evaluated by the Psychological Separation Inventory, and results were cross-validated by the Pathology of Separation-Individuation Inventory.
View Article and Find Full Text PDFUnlabelled: Clinical PET of apoptosis may have substantial value in advancing patient care. We report here the first-in-humans study with (18)F-labeled 2-(5-fluoropentyl)-2-methyl malonic acid ((18)F-ML-10), a small-molecule PET tracer for apoptosis. Presented are the dosimetry, biodistribution, stability, and safety profiles of this PET tracer in healthy human volunteers.
View Article and Find Full Text PDFAny of seven lysine residues on ubiquitin can serve as the base for chain-extension, resulting in a sizeable spectrum of ubiquitin modifications differing in chain length or linkage type. By optimizing a procedure for rapid lysis, we charted the profile of conjugated cellular ubiquitin directly from whole cell extract. Roughly half of conjugated ubiquitin (even at high molecular weights) was nonextended, consisting of monoubiquitin modifications and chain terminators (endcaps).
View Article and Find Full Text PDFMolecular imaging studies of Parkinson's disease (PD) progression mostly focus on the first 5 years after disease onset, demonstrating rapid initial nigrostriatal neuronal loss. The fate of residual functional dopaminergic nerve terminals in patients with long-standing PD has not yet been specifically explored. Therefore, we performed [(123)I]-FP-CIT single photon emission computed tomography (SPECT) in 15 patients with very long-standing PD (mean disease duration 20.
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