The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is one of the most common and aggressive malignancies of the urinary system. Despite being the first-line treatment for advanced ccRCC, vascular endothelial growth factor receptor inhibitors (VEGFRis) face significant limitations due to both initial and acquired resistance, which impede complete tumor eradication. Using a CRISPR/Cas9 library screening approach, was identified as a resistance-associated gene for three prevalent VEGFRis (Sunitinib, Axitinib, and Sorafenib).

Establishment of a Real-Time Fluorescence Isothermal Recombinase-Aided Amplification Method for the Detection of H9 Avian Influenza Virus.

The H9 subtype of avian influenza virus (AIV) has been characterized by its rapid spread, wide range of prevalence, and continuous evolution in recent years, leading to an increasing ability for cross-species transmission. This not only severely impacts the economic benefits of the aquaculture industry, but also poses a significant threat to human health. Therefore, developing a rapid and sensitive detection method is crucial for the timely diagnosis and prevention of H9 AIVs.

Oregano Essential Oil in Livestock and Veterinary Medicine.

With a growing global concern over food safety and animal welfare issues, the livestock and veterinary industries are undergoing unprecedented changes. These changes have not only brought challenges within each industry, but also brought unprecedented opportunities for development. In this context, the search for natural and safe products that can effectively replace traditional veterinary drugs has become an important research direction in the fields of animal husbandry and veterinary medicine.

Genome-wide identification and expression analysis of the KNOX family and its diverse roles in response to growth and abiotic tolerance in sweet potato and its two diploid relatives.

KNOXs, a type of homeobox genes that encode atypical homeobox proteins, play an essential role in the regulation of growth and development, hormonal response, and abiotic stress in plants. However, the KNOX gene family has not been explored in sweet potato. In this study, through sequence alignment, genomic structure analysis, and phylogenetic characterization, 17, 12 and 11 KNOXs in sweet potato (I.

Assessing the effectiveness of a residential-scale detention tank operated in a multi-objective approach using SWMM.

The volume capture ratio of annual rainfall (VCRAR) of low-impact development measures is significantly influenced by its operating characteristics, particularly for residential stormwater detention tanks (SWDTs). The multi-objective operation strategy of SWDTs, encompassing toilet flushing (TF), green space irrigation (GSI), combined TF and GSI (TF-GSI), and peak flow reduction (PFR) rate, were compared using a case study in Beijing based on the stormwater management model. The findings indicate that the VCRAR for TF, GSI, and TF-GSI rainwater harvesting targets was 89.

Multimedia image evaluation based on blockchain, visual communication design and color balance optimization.

The relationship between image processing and image analysis is inseparable. With the increasing demand for multimedia visual images, the quality of image analysis is also increasing. However, in image processing and computer vision tasks, protecting users' privacy and preventing data leakage and abuse are not handled well.

The influence of prostate volume on pathological outcomes after radical prostatectomy: A single-center retrospective study.

Currently, the association between prostate volume (PV) or prostate weight with pathological outcomes in patients with prostate cancer (PCa) is not well understood. This study aimed to explore whether PV can predict the adverse pathological outcomes of PCa patients after radical prostatectomy (RP). A total of 1063 men with confirmed localized PCa who underwent RP at the First Affiliated Hospital of Zhejiang University from January 2014 to April 2019 were retrospectively analyzed.

Effect of different MIT rainfall event division methods on volume capture ratio of annual rainfall based on bioretention assessment.

Volume capture ratio of annual rainfall (VCRAR) is the key parameter of low-impact development (LID) facilities design, which is significantly affected by the rainfall event division method. However, there is no universal agreement on how to determine an optimal division method to achieve it. A modified minimum inter-event time (MIT) method based on MATLAB software was proposed to find an optimal MIT value.

Repeated fluctuation of Cu concentration during photocatalytic purification of SMZ-Cu combined pollution: Behavior, mechanism and application.

Although the effect of Cu on antibiotic removal during photocatalytic reaction has been studied in depth, there is less known about the effect of antibiotics on Cu removal. In this study, we report for the first time that, during the photocatalytic purification of sulfamerazine (SMZ) and Cu combined pollution, Cu concentration showed an obvious five-stage fluctuation, which was completely different from the simple promotion or inhibition reported in previous studies. By employing HPLC-MS analysis and density functional theory (DFT) calculation, the repeated fluctuation of Cu concentration was found to be closely related to the SMZ degradation process, mainly resulting from solution pH drop and formation of Cu-containing intermediates which acted as sacrificial agents for Cu reduction.

The Phytophthora sojae effector PsFYVE1 modulates immunity-related gene expression by targeting host RZ-1A protein.

Oomycete pathogens secrete numerous effectors to manipulate plant immunity and promote infection. However, relatively few effector types have been well characterized. In this study, members of an FYVE domain-containing protein family that are highly expanded in oomycetes were systematically identified, and one secreted protein, PsFYVE1, was selected for further study.

Research Status and Application Prospects of the Medicinal Mushroom Armillaria mellea.

Armillaria is one of the most common diseases underlying chronic root rot in woody plants. Although there is no particularly effective way to prevent it, soil disinfection is a common effective protective measure. However, Armillaria itself has important medicinal value and is a symbiotic fungus in the cultivation of Gastrodia elata and Polyporus umbellatus.

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases.

Circular RNAs (circRNAs) are a class of noncoding RNAs with closed-loop of single-stranded RNA structure. Although most of the circRNAs do not directly encode proteins, emerging evidence suggests that circRNAs play a pivotal and complex role in multiple biological processes by regulating gene expression. As one of the most popular circRNAs, circular homeodomain-interacting protein kinase 3 (circHIPK3) has frequently gained the interest of researchers in recent years.

Cognitive Attitudes of International Mainstream Media to China during the Contaminated Water and Human Health Under Big Data.

The water pollution affecting human health is a crisis and big test, which tests the mainstream news media's ability and level of communication to respond to major public opinions and public emergencies. The contaminated water is a crisis and a major test, which tests the ability and level of communication of major news outlets to respond to important common views and emergencies. It aims to understand the perception and attitude of the international mainstream media towards China during the contaminated water.

Based on Contaminated Water and Human Health to Change of China's International Image Under Mainstream Media Reports During the COVID-19 Pandemic.

As water quality can be an indicator of public health, it cannot be ignored. We can regard the international image of a country as a kind of soft national power, which embodies the comprehensive strength of the country and plays a very important role in safeguarding the interests of a country. This article aims to study the changes in China's international image under mainstream media reports during the COVID-19 pandemic.

c-Met: A Promising Therapeutic Target in Bladder Cancer.

Mesenchymal-epithelial transition factor (c-Met) belongs to the tyrosine kinase receptor family and is overexpressed in various human cancers. Its ligand is hepatocyte growth factor (HGF), and the HGF/c-Met signaling pathway is involved in a wide range of cellular processes, including cell proliferation, migration, and metastasis. Emerging studies have indicated that c-Met expression is strongly associated with bladder cancer (BCa) development and prognosis.

FTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an mA dependent pathway.

FTO, as an mA mRNA demethylase, is involved in various cancers. However, the role of FTO in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we discovered FTO is upregulated in ccRCC.

Construction of a Co-Expression Network for lncRNAs and mRNAs Related to Urothelial Carcinoma of the Bladder Progression.

Carcinoma of urinary bladder is the most familiar cancer of the urinary tract, with the highest incidence in men. However, its prognosis and treatment have not improved significantly in the last 30 years. The main reason for this may be related to the alteration and regulation of genes.

Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma.

Background: Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) is a member of the PAS superfamily. Previous studies explored the carcinogenic roles of transcription factor ARNTL2 in human malignancies. However, its roles in ccRCC have not been elucidated.

Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis.

Background:  Studies have shown that AR-V7 may be correlated with the poor prognosis of castration resistant prostate cancer (CRPC), however, clinicopathological characteristics of AR-V7 have not been fully elucidated.

Objective: This study aimed at evaluating the clinicopathological features of AR-V7 in CRPC patients.

Materials And Methods: To evaluate the clinicopathological features of AR-V7 in CRPC patients.

Rapid and simple detection of in strawberry using a coupled recombinase polymerase amplification-lateral flow strip assay.

Unlabelled: is a devastating pathogen that infects a wide range of plants and causes Phytophthora rot disease, which has resulted in great economic losses in crop production. Therefore, the rapid and practicable detection of is important for disease monitoring and forecasting. In this study, we developed a lateral flow recombinase polymerase amplification (LF-RPA) assay for the sensitive visual detection of .

Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers.

The incidence of urological cancer has been gradually increasing in the last few decades. However, current diagnostic tools and treatment strategies continue to have limitations. Substantial evidence shows that long noncoding RNAs (lncRNAs) play essential roles in carcinogenesis and the progression, treatment response and prognosis of multiple human cancers, including urological cancers, gastrointestinal tumours, reproductive cancers and respiratory neoplasms.

Facile synthesis of highly crystalline g-CN nanosheets with remarkable visible light photocatalytic activity for antibiotics removal.

g-CN has attracted much attention in photocatalysis field because of its good visible light response. However, its photocatalytic activity is still greatly limited by fast carriers recombination and small specific surface. In order to promote carriers separation and pollutants adsorption, a facile synthesis scheme combining hydrothermal method with secondary calcination process under N gas protection was developed, and highly crystalline g-CN nanosheets (HCCNNS) were successfully prepared.