Publications by authors named "Zitong Song"

Background: Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome-, transcriptome- and proteome-wide association analyses.

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The separation of acetylene (CH) from ethylene (CH) and ethane (CH) is crucial for the production of high-purity CH and the recovery of other gases. Polyhedron-based metal-organic frameworks (PMOFs) are characterized by their spacious cavities, which facilitate gas trapping, and cage windows with varying sizes that enable gas screening. In this study, we carefully selected a class of PMOFs based on V-type tetracarboxylic acid linker ( containing benzene ring, containing urea group and recombinant reconstructed on the basis of ) to study the relationship between pore environment and C adsorption and separation performance.

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Article Synopsis
  • Genome-wide association studies have linked numerous genetic variants to obesity, but many have yet to reveal their biological significance, particularly in the brain's role in obesity development.
  • The researchers conducted proteome-wide association studies, finding 51 genes associated with obesity-related traits like body fat and waist circumference; these genes are involved in various metabolic processes and have potential for drug repurposing.
  • The findings highlight the connection between genetic variants and brain protein abundance in obesity, suggesting these proteins could be important targets for new obesity treatments in the future.
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Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of excessive adiposity and low muscle mass or function. Although obesity and sarcopenia are heritable conditions, the genetic determinants of SO have not been fully understood. We conducted a large-scale exome-wide association analysis of SO in a sequenced sample of 2 887 cases and 113 284 controls and an imputed sample of 4 003 cases and 161 990 controls in the UK Biobank cohort.

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Most human papillomavirus (HPV) types, including HPV16 and HPV18, are closely related to the occurrence of cervical cancer, predominantly through the action of viral oncoproteins E6 and E7. Curcumin, the active ingredient of the turmeric plant, has been gaining attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In the present study, the HPV-positive cervical cancer cells HeLa and CaSki were treated with curcumin, and the results showed that curcumin has a dose-dependent and time-dependent inhibitory effect on cell viability.

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Acetylene is an important industrial gas for the production of vinyl chloride and 1,4-butynediol, but its storage remains a major challenge because it is highly explosive. Flexible metal-organic frameworks (FMOFs) are always at the forefront of porous materials due to the transformation of the structure under the external stimuli. In this work, divalent metal ions and multifunctional aromatic N,O-donor ligands were chosen, and three FMOFs [M(DTTA)]·guest [M = Mn (), Cd (), and Cu ()] (HDTTA = 2,5-bis(1-1,2,4-trazol-1-yl) terephthalic acid) have been successfully constructed.

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An approach was proposed and developed to recover the 3D shape concealed in a shelter with a small hole only using three laser scatterings. This approach extends reconstruction of concealed 3D shape from "around a corner" to "through a small hole". Based on principle of rectilinear propagation of light, a simple geometric mapping tentative theoretical frame independent of scene was proposed to extract 3D information of concealed objects.

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