Background: Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome-, transcriptome- and proteome-wide association analyses.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2024
The separation of acetylene (CH) from ethylene (CH) and ethane (CH) is crucial for the production of high-purity CH and the recovery of other gases. Polyhedron-based metal-organic frameworks (PMOFs) are characterized by their spacious cavities, which facilitate gas trapping, and cage windows with varying sizes that enable gas screening. In this study, we carefully selected a class of PMOFs based on V-type tetracarboxylic acid linker ( containing benzene ring, containing urea group and recombinant reconstructed on the basis of ) to study the relationship between pore environment and C adsorption and separation performance.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
April 2024
Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of excessive adiposity and low muscle mass or function. Although obesity and sarcopenia are heritable conditions, the genetic determinants of SO have not been fully understood. We conducted a large-scale exome-wide association analysis of SO in a sequenced sample of 2 887 cases and 113 284 controls and an imputed sample of 4 003 cases and 161 990 controls in the UK Biobank cohort.
View Article and Find Full Text PDFMost human papillomavirus (HPV) types, including HPV16 and HPV18, are closely related to the occurrence of cervical cancer, predominantly through the action of viral oncoproteins E6 and E7. Curcumin, the active ingredient of the turmeric plant, has been gaining attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In the present study, the HPV-positive cervical cancer cells HeLa and CaSki were treated with curcumin, and the results showed that curcumin has a dose-dependent and time-dependent inhibitory effect on cell viability.
View Article and Find Full Text PDFAcetylene is an important industrial gas for the production of vinyl chloride and 1,4-butynediol, but its storage remains a major challenge because it is highly explosive. Flexible metal-organic frameworks (FMOFs) are always at the forefront of porous materials due to the transformation of the structure under the external stimuli. In this work, divalent metal ions and multifunctional aromatic N,O-donor ligands were chosen, and three FMOFs [M(DTTA)]·guest [M = Mn (), Cd (), and Cu ()] (HDTTA = 2,5-bis(1-1,2,4-trazol-1-yl) terephthalic acid) have been successfully constructed.
View Article and Find Full Text PDFAn approach was proposed and developed to recover the 3D shape concealed in a shelter with a small hole only using three laser scatterings. This approach extends reconstruction of concealed 3D shape from "around a corner" to "through a small hole". Based on principle of rectilinear propagation of light, a simple geometric mapping tentative theoretical frame independent of scene was proposed to extract 3D information of concealed objects.
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