Publications by authors named "Zitong Huang"

Article Synopsis
  • - The study highlights the rising incidence of rabies exposure in Guangzhou, China, with over 524,000 cases reported from 2020 to 2022, indicating a significant increase in risk for the population.
  • - Using specific statistical methods, the research assessed how accessible rabies post-exposure prophylaxis (PEP) clinics are for patients across different districts in Guangzhou, revealing disparities in accessibility based on geographic location.
  • - The findings emphasize the need for better resource allocation to address these accessibility issues, supporting the WHO’s goal of eliminating human deaths from dog-mediated rabies by 2030.
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Article Synopsis
  • The study investigates the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and Restless Legs Syndrome (RLS), finding a causal effect where ADHD increases the risk of developing RLS, but not vice versa.
  • Genetic analysis showed no significant correlation between the two disorders, although RLS may be linked to lower serum ferritin levels, indicating a genetic predisposition.
  • Limitations include the focus on European ancestry populations, which may affect the applicability of the findings to other groups, and the study highlights the importance of considering RLS in ADHD diagnoses.
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Background And Aims: The relationship between alcohol consumption and age-related diseases is inconsistent. Biological age (BA) serves as both a precursor and a predictor of age-related diseases; however, longitudinal associations between alcohol consumption and BA in middle-aged and older people remain unclear. We measured whether there was a longitudinal association between drinking frequency and pure alcohol intake with BA among middle-aged and older people.

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Objective: To investigate the longitudinal association between alcohol abstinence and accelerated biological aging among middle-aged and older adults and to explore the potential effect modifiers influencing the association.

Methods: Utilizing the clinico-biochemical and anthropometric data from the baseline and first repeat survey of the UK Biobank (UKB), we employed the Klemera and Doubal method (KDM) to construct the biological age (BA) and calculate BA acceleration. Change analysis based on multivariate linear regression models was employed to explore the association between changes in alcohol abstinence and changes in BA acceleration.

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Introduction: Although the global COVID-19 emergency ended, the real-world effects of multiple non-pharmaceutical interventions (NPIs) and the relative contribution of individual NPIs over time were poorly understood, limiting the mitigation of future potential epidemics.

Methods: Based on four large-scale datasets including epidemic parameters, virus variants, vaccines, and meteorological factors across 51 states in the United States from August 2020 to July 2022, we established a Bayesian hierarchical model with a spike-and-slab prior to assessing the time-varying effect of NPIs and vaccination on mitigating COVID-19 transmission and identifying important NPIs in the context of different variants pandemic.

Results: We found that (i) the empirical reduction in reproduction number attributable to integrated NPIs was 52.

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Background: The non-pharmaceutical interventions (NPIs) against COVID-19 may have affected the transmission of hand, foot and mouth disease (HFMD). We aimed to assess the impact of the NPIs on HFMD in the high epidemic area of HFMD, Guangdong Province.

Methods: The data of HFMD cases, etiological information, and meteorological factors in Guangdong from January 1, 2012, to December 31, 2021, were collected.

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Background: The biological aging process can be modified through lifestyle interventions to prevent age-related diseases and extend healthspan. However, evidence from population-based studies on whether tea consumption could delay the biological aging process in humans remains limited.

Methods: This study included 7931 participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) Study and 5998 participants aged 37-73 years from the UK Biobank (UKB) who participated in both the baseline and first follow-up surveys.

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Neuroimaging studies have identified significant differences in brain structure, function, and connectivity between endurance runners and healthy controls. However, the topological organization of large-scale functional brain networks remains unexplored in endurance runners. Using resting-state functional magnetic resonance imaging data, this study examined the differences in the topological organization of functional networks between endurance runners (n = 22) and healthy controls (n = 20).

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Exosomes are a class of extracellular vesicles released by bacteria and contain diverse biomolecules. In this study, we isolated exosomes from Vibrio harveyi and Vibrio anguillarum, which are both serious pathogens in mariculture, using a supercentrifugation method, and the proteins in the exosomes of these two vibrios were analyzed by LC-MS/MS proteomics. Exosome proteins released by V.

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Background: Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.

Methods: Using patch-clamp recording, immunostaining, molecular biological approaches and behaviour tests, we elucidated a critically functional role of tyramine in regulating membrane excitability and pain sensitivity by manipulating Kv1.

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Article Synopsis
  • - In May 2021, Guangzhou City in China experienced its first local outbreak of the SARS-CoV-2 Delta variant, prompting an analysis of its epidemiological characteristics and spatial-temporal clustering.
  • - Researchers analyzed 153 cases using the Knox test, revealing higher clustering among male pairs and a concentration of cases in individuals aged 18 or younger, as well as older than 60.
  • - Public health measures significantly reduced the clustering strength, indicating that timely interventions are critical in managing outbreaks with high transmission rates.
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Parkinson's disease (PD) can be classified into an akinetic-rigid (AR) and a tremor-dominant (TD) subtype based on predominant motor symptoms. Patients with different motor subtypes often show divergent clinical manifestations; however, the underlying neural mechanisms remain unclear. This study aimed to characterize the cortical and subcortical morphological alterations in motor subtypes of PD.

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Irritable bowel syndrome (IBS) is usually associated with chronic gastrointestinal disorders. Its most common subtype is accompanied with diarrhea (IBS-D). The enteric nervous system (ENS) modulates major gastrointestinal motility and functions whose aberration may induce IBS-D.

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Patchouli alcohol (PA) has been widely used for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) in traditional Chinese medicine, and the related mechanism remains to be fully understood. Our previous study has indicated that PA significantly reduced visceral sensitivity and defecation area in IBS-D rats. In this study, we prepared an IBS-D rat model and observed the dynamic intestinal motility and colonic longitudinal muscle and myenteric plexus (LMMP) neurons, as well as their subtypes at D14, D21, and D28.

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N-doped TiO-BiWO (NTB) three-component photocatalyst was prepared using a glycol solvothermal method. The photocatalysts and films were characterized, and applied to the degradation of tetracycline (TC) in milk and its effect on the quality of milk. The results show that the NTB photocatalyst exhibits good photocatalytic activity under visible light, and its TC degradation rate is increased by 1.

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Intracortical myelin is involved in speeding and synchronizing neural activity of the cerebral cortex and has been found to be disrupted in various psychiatric disorders. However, its role in obsessive-compulsive disorder (OCD) has remained unknown. In this study, we investigated the alterations in intracortical myelin and their association with white matter (WM) microstructural abnormalities in OCD.

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A novel diastereodivergent tricyclization of isocyanoacetates with -quinone methides was accomplished for the efficient synthesis of chromeno[2,3-]chromene derivatives. All three reactive centers of isocyanoacetate reacted sequentially with two -QMs, affording the products with four adjacent stereocenters in a diastereoselective manner. The asymmetric version was preliminarily investigated.

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Objectives: To investigate the activity of key rate-limiting enzymes of glucose metabolism after restoration of spontaneous circulation (ROSC), to explore the potential pathophysiological mechanism of impaired myocardial energy metabolism after cardiopulmonary resuscitation (CPR).

Methods: Twenty-one male Sprague-Dawley rats were randomized into three experimental groups assigned in accordance with different observation times after ROSC: Sham, instrumented rats without induced cardiac arrest or resuscitation; post-resuscitation (PR2 h); PR24 h. In these groups, CPR, including precordial compressions and synchronized mechanical ventilation, was initiated 6 min after asphyxia-induced cardiac arrest.

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