Peptidyl-prolyl isomerase F as a prognostic biomarker associated with immune infiltrates and mitophagy in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is among the most prevalent malignancies worldwide, with unfavorable treatment outcomes. Peptidyl-prolyl isomerase F () is known to influence the malignancy traits of tumor progression by modulating the bioenergetics and mitochondrial permeability in cancer cells; however, its role in LUAD remains unclear. Our study seeks to investigate the clinical significance, tumor proliferation, and immune regulatory functions of in LUAD.

Oncogenic HPV-induced high expression of ESM1 predicts poor prognosis and regulates aerobic glycolysis in cervical cancer.

The impact of endothelial cell-specific molecule 1 (ESM1) on the initiation and progression of diverse cancers has been extensively studied, yet its regulatory mechanisms in relation to cervical cancer remain insufficiently understood. Through bioinformatics analysis, we revealed that ESM1 was highly expressed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and correlated with dismal clinicopathological features. The activation of ESM1 is facilitated by the presence of oncogenic HPV E6 and E7.

Assessing the use of PEC and jf methods for strengthening the evaluation of new heat exchangers.

The new type of heat exchanger uses the micro heat pipe as the main heat transfer material. Compared with the traditional heat exchanger of the same kind, the performance of the new type of heat exchanger has significantly improved. By studying the evaluation method of strengthening the performance of the heat exchanger, the performance of the heat exchanger can be further optimized.

Occurrence of Anthracnose Caused by on in Southern China.

Vahl. is a Moraceae plant, named for its palm-like leaves. It is a widely used traditional medicinal material with definite curative effect.

Cyclin O promotes lung cancer progression and cetuximab resistance via cell cycle regulation and interaction.

Background: Cyclin O () is a novel cyclin family protein containing a cyclin-like domain, which plays a role in cell cycle regulation. Recent research suggests that inhibition of leads to cell apoptosis in gastric cancer, cervical squamous cell carcinoma, and post-operative lung cancer.

Methods: The protein expression and signal transduction were detected by Western blot (WB) and immunohistochemistry (IHC).

Ultra-rapid Idylla™ mutation screening followed by next-generation sequencing: An integrated solution to molecular diagnosis of non-small cell lung cancer.

Background: Rapid profiling of the mutations is crucial to help clinicians choose the optimal treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer (NSCLC). Unfortunately, current diagnostic techniques, including ARMS-PCR and NGS, generally require several days to deliver final results. This diagnostic delay may lead to treatment delays for patients who are worsening rapidly.

Hollow-core fiber with stable propagation delay between -150°C and +60°C.

Optical fibers with a low thermal coefficient of delay (TCD) have been developed for frequency and timing transmission/distribution. However, their temperature sensitivity changes as a function of temperature and, to date, no study of such fibers has demonstrated improved performance over extended temperature ranges, especially at sub-zero temperatures. Here, we show that a hollow core fiber (HCF) with a thin acrylate coating can have a TCD within ±2.

Acupuncture combined with balloon dilation for post-stroke cricopharyngeal achalasia: A meta-analysis of randomized controlled trials.

Background: The purpose of this study was to systematically evaluate the effectiveness of acupuncture combined with balloon dilatation in patients with post-stroke cricopharyngeal achalasia (CPA) according to the effective rate, videofluoroscopy swallowing study (VFSS) score and standardized swallowing function assessment scale (SSA) score through Meta-analysis.

Methods: English and Chinese language literature published before July 24,2022 were searched in ten electronic databases. The identified articles were screened, data were extracted, and the methodological quality of the included trials was assessed.

Acupuncture for neuropathic pain: A meta-analysis of randomized control trials.

Background: Neuropathic pain (NP) is expected to increase due to the high risk of global population aging. Acupuncture has a definite clinical effect on NP. Therefore, a systematic review and meta-analysis were conducted to evaluate the effect on pain intensity and safety of acupuncture in patients with NP.

Corrigendum: Negatively regulated by miR-29c-3p, MTFR1 promotes the progression and glycolysis in lung adenocarcinoma via the AMPK/mTOR signalling pathway.

[This corrects the article DOI: 10.3389/fcell.2021.

Low-loss microwave photonics links using hollow core fibres.

There are a host of applications in communications, sensing, and science, in which analogue signal transmission is preferred over today's dominant digital transmission. In some of these applications, the advantage is in lower cost, while in others, it lies in superior performance. However, especially for longer analogue photonics links (up to 10 s of km), the performance is strongly limited by the impairments arising from using standard single-mode fibres (SSMF).

Negatively Regulated by miR-29c-3p, MTFR1 Promotes the Progression and Glycolysis in Lung Adenocarcinoma the AMPK/mTOR Signalling Pathway.

Lung adenocarcinoma (LUAD) is the major form of lung cancer that presents a major peril to public health. Owing to the high rates of morbidity, mortality and chemoresistance, it is necessary to develop more effective therapeutic targets of LUAD. Mitochondrial fission regulator 1 (MTFR1) affects the occurrence and development of some diseases by regulating mitochondrial dynamics and is dysregulated in LUAD.

Thinly coated hollow core fiber for improved thermal phase-stability performance.

The optical phase accumulated when light propagates through an optical fiber changes with temperature. It has been shown by various authors that this thermal phase sensitivity is significantly smaller in hollow core fibers (HCFs) than in standard single-mode fibers (SSMFs). However, there have been considerable differences in the level of sensitivity reduction claimed, with factors in the range ×3 to ×20 improvement for HCFs relative to SSMFs reported.

Integrated bioinformatics analysis of differentially expressed genes and immune cell infiltration characteristics in Esophageal Squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a life-threatening thoracic tumor with a poor prognosis. The role of molecular alterations and the immune microenvironment in ESCC development has not been fully elucidated. The present study aimed to elucidate key candidate genes and immune cell infiltration characteristics in ESCC by integrated bioinformatics analysis.

Dietary supplements and herbal medicine for COVID-19: A systematic review of randomized control trials.

Background: The world is currently struggling with the Coronavirus disease 2019 (COVID-19) pandemic. Dietary supplements (DSs) and herbal medicine provide a potentially convenient and accessible method for its recovery, but direct evidence is limited.

Objective: This study aims to investigate the effectiveness of DSs and herbs in patients with COVID-19.

Let-7b-3p inhibits tumor growth and metastasis by targeting the BRF2-mediated MAPK/ERK pathway in human lung adenocarcinoma.

Background: Lung cancer is a malignant tumor with the highest morbidity and mortality rates worldwide, of which lung adenocarcinoma (LUAD) is the most common subtype. Overall, current treatments of LUAD are not satisfactory; therefore, novel targets need to be explored. Let-7b-3p is an important member of the let-7 family of microRNAs (miRNAs), and has not been studied separately in LUAD.

Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Design: Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score.

Oncogenic role of abnormal spindle‑like microcephaly‑associated protein in lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is a common malignant cancer worldwide. It is urgent to explore its underlying molecular mechanism and identify novel diagnostic biomarkers. Abnormal spindle‑like microcephaly (ASPM) has recently received considerable attention due to its function in tumor progression.

Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway.

Lung adenocarcinoma (LUAD) is the main subtype of lung cancer. In this study, we found that RBP Mex3a was significantly upregulated in LUAD tissues and elevated Mex3a expression was associated with poor LUAD prognosis and metastasis. Furthermore, we demonstrated that Mex3a knockdown significantly inhibited LUAD cell migration and invasion in vitro and metastasis in nude mice.

Tuina for cervical vertigo: A systematic review and meta-analysis of randomized controlled trials.

Background And Purpose: Cervical vertigo (CV), one of the most common causes of vertigo, makes patients feel dizzy, which seriously affects patients' lives. As a traditional Chinese bone-setting manipulation, Tuina is widely used to treat CV. This article aims to evaluate the effectiveness and safety of Tuina for CV.

The Effectiveness and Safety of Acupoint Catgut Embedding for the Treatment of Postmenopausal Osteoporosis: A Systematic Review and Meta-Analysis.

Purpose: To evaluate the effectiveness and safety of acupoint catgut embedding therapy (ACET) in postmenopausal osteoporosis (PMOP).

Methods: Review of some databases from their inception to June 2018 and randomized controlled trials (RCTs) in which ACET with PMOP were included. Two researchers extracted and evaluated the information independently.

Narrow-linewidth swept laser phase reconstruction and noise measurement technology and its applications.

A dynamic noise characterization technique for measuring narrow-linewidth frequency-sweep lasers based on phase reconstruction method is proposed. The phase and the frequency fluctuation power spectral density (PSD) of the swept optical field within a specific time window are recovered mainly by demodulating the differential phase information of the 120-degree phase difference interferometer. Then the details of the laser noise characteristics and the performance evolution law of the frequency sweep process can be observed by investigating the calculated frequency fluctuation PSD.

Ultra-low noise optical injection locking amplifier with AOM-based coherent detection scheme.

A novel optical injection locking amplifier with acousto-optic modulator based phase modulation and a coherent detection scheme for optical frequency transfer applications is experimentally demonstrated in this study. A commercial distributed feedback diode laser is injection-locked to the resonant frequency of the optical signal with an optical fiber path length of hundreds of kilometers. This provides approximately 59 dB gain and ensures that the input carrier frequency fractional stability can be as good as 10 at 1000 s.