The analgesic efficacy of suprofen in periodontal and oral surgical pain.

Suprofen is a new, orally effective nonsteroidal antiinflammatory analgesic of the propionic acid chemical class. Three separate single-dose studies were performed to evaluate the efficacy of suprofen in acute pain associated with periodontal surgery and removal of impacted third molars. Study medications were: A--suprofen 200 mg, codeine 60 mg, propoxyphene HCl 65 mg, and placebo; B--suprofen 400 mg and 200 mg, aspirin 650 mg, and placebo; C--suprofen 400 mg and 200 mg, aspirin 650 mg with codeine 60 mg, aspirin 650 mg alone, and placebo.

Double-blind evaluation of suprofen and aspirin in the treatment of periodontal pain.

A double-blind, randomized, parallel group, placebo-controlled study was carried out to compare the safety and efficacy of single doses of suprofen (200 mg and 400 mg) with aspirin (650 mg) and placebo in relieving pain. In patients with pain resulting from periodontal surgery, a single dose of suprofen 200 or 400 mg was significantly better than placebo in reducing pain intensity and providing pain relief. The superiority of both doses of suprofen over placebo was demonstrated in every parameter in which pain intensity or pain relief was calculated.

[Endobrachyesophagus (Barrett's syndrome)--a not sufficiently familiar disease pattern (author's transl)].

The clinical picture of endobrachyesophagus (Barrett's Syndrome) which is little known among radiologists, is described, taking the authors' own observations into account. As soon as the complications leading to clinically manifest complaints occur, consisting of high or centrally positioned peptic stenosis and/or ulceration, diagnosis can be established by means of the usually characteristic findings when a barium sulfate contrast medium is made to pass through the esophagus. Endoscopic-bioptic exploration of the esophagus is mandatory to verify the diagnosis, and, in particular, to exclude any malignant process, the more so since malignant degeneration of cylindrical cell metaplasia, on which endobrachesophagus is based, must be reckoned with in up to 10% of the cases.

The differential diagnosis of Crohn's disease by conventional radiological examination.

The difficulties in the differential diagnosis of Crohn's disease are discussed on the basis of 35 patients observed at the Kantonsspital of Lucerne. The value of various radiographic signs as indicators of the stage and duration and the activity of the disease is critically analysed. Functional radiological signs, such as spasm, hypertonia and edema of the intestinal folds cannot be interpreted as early signs of Crohn's disease.