Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank.

Background: Accelerated biological aging has been verified to be a critical risk factor for a number of age-related diseases, but its role in dementia remained unclear. Whether it modified the effects of genetic factors was also unknown. This study evaluated the associations between accelerated biological aging and dementia and the moderating role of accelerated biological aging in the genetic susceptibility to the disease.

Examining individual and contextual predictors of disability in Chinese older adults: A machine learning approach.

Background: There is a large gap of understanding the determinants of disability, especially the contextual characteristics. Therefore, this study aimed to examine the important predictors of disability in Chinese older adults based on the social ecological framework.

Methods: We used the China Health and Retirement Longitudinal Study to examine predictors of disability, defined as self-report of any difficulty for six activity of daily living items.

Long-term PM2.5 exposure and peak expiratory flow in middle-aged and older people in China: A quasi-experimental study.

China's Clean Air Act (CCAA) has been demonstrated to reduce the public health burden of ambient air pollution. Few studies have assessed the health effects of CCAA on lung function. We aimed to investigate the effects of CCAA and PM2.

Long-term effect of extreme temperature on cognitive function of middle-aged and older adults in China.

Background: Several studies have explored the association between temperature and cognitive function. However, few studies have examined the effect of extreme temperature on cognitive function. In this study, we aimed to quantify the long-term effect of extreme temperature (e.

Long-Term PM2.5 Exposure, Lung Function, and Cognitive Function Among Middle-Aged and Older Adults in China.

Background: Long-term exposure to PM2.5 is related to poor lung function and cognitive impairment, but less is known about the pathway involved in this association. We aimed to explore whether the effect of PM2.

The effect of PM levels on continuum functional capability among older adults: Potential cause-effect or statistical associations.

Background: Since there is limited knowledge about health effects of the clean air policy (CAP, i.e., a series of emission-control actions) on continuum functional capacity (CFC) among the older adults on a large representative data, our research was to fill this gap.

Theoretical Insights into the Selective Separation of Am(III)/Eu(III) Using Hydrophilic Triazolyl-Based Ligands.

Designing ligands with efficient actinide (An(III))/lanthanide (Ln(III)) separation performance is still one of the key issues for the disposal of accumulated radioactive waste and the recovery of minor actinides. Recently, the hydrophilic ligands as promising extractants in the innovative Selective ActiNide Extraction (i-SANEX) process show excellent selectivity for Am(III) over Eu(III), such as hydroxylated-based ligands. In this work, we investigated the selective back-extraction toward Am(III) over Eu(III) with three hydrophilic hydroxylated triazolyl-based ligands (the skeleton of pyridine , bipyridine , and phenanthroline ) using scalar-relativistic density functional theory.

Association of long-term exposure to PM with hypertension and diabetes among the middle-aged and elderly people in Chinese mainland: a spatial study.

Background: Epidemiological evidence has shown an association between long-term exposure to fine particulate matter (PM) and hypertension and diabetes, but few studies have considered the spatial properties of the samples. This study aimed to investigate the long-term effect of PM exposure on hypertension and diabetes among middle-aged and elderly people in China based on a spatial study.

Methods: We conducted a national cross-sectional study of the most recently launched wave 4 2018 data of the China Health and Retirement Longitudinal Study (CHARLS) to calculate the prevalence of hypertension and diabetes.

Seasonal prediction of daily PM concentrations with interpretable machine learning: a case study of Beijing, China.

Machine learning (ML) has shown high predictive ability in environmental research. Accurate estimation of daily PM concentrations is a prerequisite to address environmental public health issues. However, studies on the interpretability of ML algorithms were limited.

Theoretical Insights into the Separation of Am(III)/Eu(III) by Hydrophilic Sulfonated Ligands.

In this work, we focused on the separation of Am(III)/Eu(III) with four hydrophilic sulfonated ligands () based on the framework of phenanthroline and bipyridine through scalar relativistic density functional theory. We studied the electronic structures of [M(NO)] (M = Am, Eu) complexes and the bonding nature between metal and ligands as well as evaluated the separation selectivity of Am(III)/Eu(III). The tetrasulfonated ligand with a bipyridine framework has the strongest complexing ability for metal ions probably because of the better solubility and flexible skeleton.

Spatial analysis of the effects of PM2.5 on hypertension among the middle-aged and elderly people in China.

Hypertension is currently one of the most common chronic diseases with high global prevalence associated with a huge social and economic burden. In recent years, air pollution has become a focus of research, especially the effects of PM2.5 on hypertension.

Associations between modifiable lifestyle factors and multidimensional cognitive health among community-dwelling old adults: stratified by educational level.

Unlabelled: ABSTRACTBackground:Cognition is multidimensional, and each domain plays a unique and crucial part in successful daily life engagement. However, less attention has been paid to multi-domain cognitive health for the elderly, and the role of lifestyle factors in each domain remains unclear.

Methods: We conducted a cross-sectional study of 3,230 older adults aged 60+ years in Xiamen, China, in 2016.

Application of SCM with Bayesian B-Spline to Spatio-Temporal Analysis of Hypertension in China.

Most previous research on the disparities of hypertension risk has neither simultaneously explored the spatio-temporal disparities nor considered the spatial information contained in the samples, thus the estimated results may be unreliable. Our study was based on the China Health and Nutrition Survey (CHNS), including residents over 12 years old in seven provinces from 1991 to 2011. Bayesian B-spline was used in the extended shared component model (SCM) for fitting temporal-related variation to explore spatio-temporal distribution in the odds ratio (OR) of hypertension, reveal gender variation, and explore latent risk factors.

The association between renal sinus fat area and the progression-free survival in Chinese non-metastatic clear-cell renal cell carcinoma patients.

In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.

Orbicularis-levator-tarsus composite suture technique in double-eyelid operation.

Objective: Fold loss and suture extrusion are fairly common in double-eyelid surgeries. We hereby explore a new composite suture technique that aims to reduce such complications and to improve the long-term aesthetic outcome.

Methods: Based on the conventional external incision procedure, the suture procedure in our technique involves three stitches that fixate the orbicularis oculi, the levator aponeurosis, and the tarsal plate.

Interface-induced superconductivity and strain-dependent spin density waves in FeSe/SrTiO3 thin films.

The record superconducting transition temperature (T(c)) for the iron-based high-temperature superconductors (Fe-HTS) has long been 56 K. Recently, in single-layer FeSe films grown on SrTiO3 substrates, indications of a new record of 65 K have been reported. Using in situ photoemission measurements, we substantiate the presence of spin density waves (SDWs) in FeSe films--a key ingredient of Fe-HTS that was missed in FeSe before--and we find that this weakens with increased thickness or reduced strain.

[Analysis of apoptosis-related gene expression in different serum level of insulin-like growth factor-1 in mice breast cancer tissue].

Objective: A stable primary breast cancer model in liver-specific insulin-like growth factor 1 (IGF-1) deficient (LID) mice and control mice was established. To screen apoptosis related genes expression in different serum IGF-1 levels by gene chip and flow cytometry.

Methods: The LID mice and control mice were used.