Durable asymmetric silk fabric with rapid heat conduction, spectral selectivity and sweat transfer capabilities for effective personal thermal-moisture management.

Silk fabric (SF) is a high-end textile frequently utilized in summer apparel. However, its ultraviolet absorption reduces the solar energy reflection, and the inherent hydrophilicity impedes effective sweat evaporation, thereby significantly compromising thermal-moisture comfort. Herein, we fabricated a multifunctional Janus SF with rapid heat dissipation, unidirectional moisture conduction and radiative cooling capabilities through a feasible two-step process.

Trustworthy Limited Data CT Reconstruction Using Progressive Artifact Image Learning.

The reconstruction of limited data computed tomography (CT) aims to obtain high-quality images from a reduced set of projection views acquired from sparse views or limited angles. This approach is utilized to reduce radiation exposure or expedite the scanning process. Deep Learning (DL) techniques have been incorporated into limited data CT reconstruction tasks and achieve remarkable performance.

Virtual-simulation boosted neural network dose calculation engine for intensity-modulated radiation therapy.

The Monte Carlo (MC) dose calculation method is widely recognized as the gold standard for precision in dose calculation. However, MC calculations are computationally intensive and time-consuming. This study aims to develop a neural network-based dose calculation engine using a virtual simulation database, producing dose distributions with accuracy comparable to MC dose calculations.

Sliver-doped manganese oxide hollow nanospheres as dual-functional textile coatings for antibacterial and formaldehyde elimination.

Nowadays, the widespread application of nanocatalysts is limited by their inhalable powder forms and low cost-efficiency. Herein, we demonstrate a feasible technique for fabricating composite textiles incorporated with sliver-doped manganese oxide hollow nanospheres (Ag@HM nanohybrids), which exhibit dual-functionality in eliminating indoor bacteria and formaldehyde (HCHO). Specifically, the Ag@HM nanohybrids were synthesized through a stepwise process involving silica-templated synthesis of manganese oxide (MnO), selective etching of sacrificial templates, and in-situ silver redox doping.

Avian Migration-Mediated Transmission and Recombination Driving the Diversity of Gammacoronaviruses and Deltacoronaviruses.

In the wake of pandemics like COVID-19, which have zoonotic origins, the role of wildlife as reservoirs for emerging infectious diseases has garnered heightened attention. Migratory birds, traversing continents, represent a potent but under-researched vector for the spread of infectious diseases, including novel coronaviruses. This study delves into the genetic diversity and transmission dynamics of coronaviruses in migratory birds, presenting pivotal findings.

Ultrasensitive electrochemical detection of gallic acid in beverages based on nitrogen-doped multi-walled carbon nanotube networks embellished with cobalt 2-methylimidazole nanoparticles.

This work presents a convenient and easy-to-operate method for synthesizing the functionally integrated nanocomposite of nitrogen-doped multi walled carbon nanotube networks (N-CNTs) and cobalt 2-methylimidazole (ZIF-67) nanoparticles. The N-CNTs@ZIF-67 nanocomposite was utilized to design a novel electrochemical sensing platform for detecting gallic acid (GA). The N-CNTs@ZIF-67 modified glass carbon electrode (GCE) demonstrated high sensitivity for GA electrochemical detection (LOD: 10.

Development of a machine learning predictive model for central venous catheter-associated thrombosis in patients undergoing abdominal surgery.

Background: Central venous catheters (CVCs) are placed where the vena cava meets the right atrium. Their common use raises the risk of catheter-related thrombosis (CRT), a potentially life-threatening complication.

Aim: This study leverages machine learning to develop a CRT predictive model for abdominal surgery patients, aiming to refine clinical decisions and elevate treatment quality.

A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with limited treatment efficacy despite advances in immune checkpoint blockade (ICB) therapy. The inherently weak immune responses in HCC necessitate novel strategies to improve anti-tumor immunity and synergize with ICB therapy. Kinesin family member 20A (KIF20A) is a tumor-associated antigen (TAA) overexpressed in HCC, and it could be a promising target for vaccine development.

Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia.

This study established an animal model of comorbid depression and insomnia by combining chronic unpredictable mild stress (CUMS) with sleep deprivation (SD). The pathogenesis of comorbid depression and insomnia may be associated with impaired AMPK/FOXO3a signaling, which mediates autophagy inhibition, leading to decreased pineal melatonin secretion. The findings revealed that CUMS + SD rats exhibited more pronounced depression-like behaviors, sleep disorders, increased central oxidative stress, and exacerbated neuroinflammation, accompanied by reduced levels of 5-hydroxytryptophan (5-HT) and melatonin in the pineal gland.

Research trends and key contributors in studies on influenza vaccines for children: A 20-year bibliometric analysis.

Globally, there are over 3 million severe cases of influenza each year, leading to up to half a million deaths. This study provides a comprehensive analysis of the current status of children's influenza vaccine research over the past 20 years and explores potential future research trends, including improvements in vaccine coverage and strategies to address vaccine hesitancy. We extracted all research data on children's influenza vaccines from 2004 to 2024 using the Web of Science Core Collection (WOSCC).

Pink1/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia.

Using a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression combined with insomnia were simulated. The abnormal mitochondrial autophagy signaling caused by the putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) signaling pathway directly affects the normal secretion of melatonin by the pineal gland, which may explain the pathogenesis of depression combined with insomnia. This study aims to explore the depression-like behavior, sleep changes, central oxidative stress response, pineal mitochondrial autophagy damage, melatonin secretion, histopathological changes of the pineal gland, and the expression of Pink1/Parkin signaling-related factors in CUMS+SD rats.

Room-temperature fabrication of zeolitic imidazolate framework-8 nanoparticles combined with graphitized and carbonylated carbon nanotubes networks for the ultrasensitive gallic acid electrochemical detection.

Gallic acid (GA) has important application value in several fields of foods, medicines, and chemical engineering. However, the excessive intake of GA may cause gastrointestinal discomfort and nerve damage. Herein, an economical room-temperature fabrication strategy was reported for the preparation of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles combined with graphitized and carbonylated carbon nanotubes (GCMCN) networks, which were used to achieve the ultrasensitive electrochemical detection of GA.

Predictive value of bone metabolism markers in the progression of diabetic kidney disease: a cross-sectional study.

Objective: This study aimed to investigate the relationship between bone metabolism markers, including serum klotho, fibroblast growth factor 23 (FGF23), 25(OH)D3, iPTH, calcium (Ca), and PHOS and the progression of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Additionally, the predictive value of these markers for DKD progression was evaluated.

Methods: This study involved 126 patients with T2DM between May 2021 and March 2023.

Integrated gut microbiome and UHPLC-MS metabolomics to reveal the prevention mechanism of pidanjiangtang granules on IGT Rats.

Introduction: Pidanjiangtang (PDJT) is a traditional Chinese medicine formula empirically used to treat impaired glucose tolerance (IGT) based on the "Pidan" theory from the classic ancient book Nei Jing. However, the mechanism of PDJT intervention for IGT remains to be studied.

Objective: This study aims to explore the mechanism of PDJT granules intervention in IGT by integrating gut microbiome and UHPLC-MS untargeted metabolomics.

Electrochemical Synthesis of Quinazolines: N-H/C(sp)-H Coupling of -Carbonyl Anilines with Amino Acids and Amines.

A mild and efficient electrochemical protocol for the synthesis of quinazolines through N-H/C(sp)-H coupling of -carbonyl anilines with natural amino acids/amines has been developed. The products quinazolines can easily be isolated in moderate to excellent yields under external chemical oxidant-free conditions. Moreover, this reaction can be safely conducted on gram scale.

Influence of S(IV) reduction on the reaction mechanisms and the generation of reactive oxygen species in B-Cu@Fe/PPS system.

Heterogeneous sulfite-based advanced oxidation process is extremely promising for the removal of various industrial pollutants owing to its generation of multiple reactive oxygen species (ROS), while the unclear mechanism of S(IV) conversion and ROS generation hinder its practical applications. Here, the iron-copper bimetallic was synthesized for potassium pyrosulfate catalysis, which was designed for insight into the mechanism of micropollutant degradation driven by sulfur species conversion. Experimental and theoretical calculations have shown that the reaction process and corresponding mechanisms can be significantly distinguished into three different stages.

Bibliometric analysis of orexin: A promising neuropeptide.

Background: Orexin is an excitatory neuropeptide produced in the lateral hypothalamus, playing a role in various physiological functions in humans. There is a growing body of literature on orexins. This paper utilizes CiteSpace software to organize and analyze a significant number of articles on orexin, providing readers with an intuitive overview of research trends and emerging hot topics in this field.

Sulfonyl Radical-Induced Regioselective Cyclization of Enamide-Olefin To Form Sulfonylated 6-7-Membered Cyclic Enamines.

Remarkable progress has been made in the radical cascade cyclization of heteroaryl- or aryl-tethered alkenes to construct benzene-fused frameworks via the cracking of aryl C-H bonds. In contrast, the radical cascade cyclization of linear dienes through the cracking of vinyl C-H bonds to construct nonbenzene-fused ring frameworks with endocyclic double bonds has significantly lagged behind, and major advances have largely been restricted to the generation of 5-membered heterocycles, such as pyrrolinones. Herein, we report the silver-mediated regioselective sulfonylation-cyclization of linear dienes with sodium sulfinates to form sulfonylated 6- and 7-membered cyclic enamines.

Subtypes of borderline personality features in adolescence: Insights from cross-lagged panel network analysis.

Borderline personality disorder (BPD) is a complex and severe psychiatric condition characterized by emotional, self-image, behavior, and relational instability. While adult BPD heterogeneity has been extensively studied, the phenomenological borderline personality features (BPFs) in adolescence remain uninvestigated. This study aimed to explore the potentially dynamic causal relationships between BPFs in adolescence and identify the subtypes through cross-lagged panel network (CLPN) analysis.

The positive role of transforming growth factor-β1 in ischemic stroke.

Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage.

Dual-Domain Collaborative Diffusion Sampling for Multi-Source Stationary Computed Tomography Reconstruction.

The multi-source stationary CT, where both the detector and X-ray source are fixed, represents a novel imaging system with high temporal resolution that has garnered significant interest. Limited space within the system restricts the number of X-ray sources, leading to sparse-view CT imaging challenges. Recent diffusion models for reconstructing sparse-view CT have generally focused separately on sinogram or image domains.