Publications by authors named "Zirong Li"

Silk fabric (SF) is a high-end textile frequently utilized in summer apparel. However, its ultraviolet absorption reduces the solar energy reflection, and the inherent hydrophilicity impedes effective sweat evaporation, thereby significantly compromising thermal-moisture comfort. Herein, we fabricated a multifunctional Janus SF with rapid heat dissipation, unidirectional moisture conduction and radiative cooling capabilities through a feasible two-step process.

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The reconstruction of limited data computed tomography (CT) aims to obtain high-quality images from a reduced set of projection views acquired from sparse views or limited angles. This approach is utilized to reduce radiation exposure or expedite the scanning process. Deep Learning (DL) techniques have been incorporated into limited data CT reconstruction tasks and achieve remarkable performance.

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The Monte Carlo (MC) dose calculation method is widely recognized as the gold standard for precision in dose calculation. However, MC calculations are computationally intensive and time-consuming. This study aims to develop a neural network-based dose calculation engine using a virtual simulation database, producing dose distributions with accuracy comparable to MC dose calculations.

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Nowadays, the widespread application of nanocatalysts is limited by their inhalable powder forms and low cost-efficiency. Herein, we demonstrate a feasible technique for fabricating composite textiles incorporated with sliver-doped manganese oxide hollow nanospheres (Ag@HM nanohybrids), which exhibit dual-functionality in eliminating indoor bacteria and formaldehyde (HCHO). Specifically, the Ag@HM nanohybrids were synthesized through a stepwise process involving silica-templated synthesis of manganese oxide (MnO), selective etching of sacrificial templates, and in-situ silver redox doping.

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In the wake of pandemics like COVID-19, which have zoonotic origins, the role of wildlife as reservoirs for emerging infectious diseases has garnered heightened attention. Migratory birds, traversing continents, represent a potent but under-researched vector for the spread of infectious diseases, including novel coronaviruses. This study delves into the genetic diversity and transmission dynamics of coronaviruses in migratory birds, presenting pivotal findings.

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This work presents a convenient and easy-to-operate method for synthesizing the functionally integrated nanocomposite of nitrogen-doped multi walled carbon nanotube networks (N-CNTs) and cobalt 2-methylimidazole (ZIF-67) nanoparticles. The N-CNTs@ZIF-67 nanocomposite was utilized to design a novel electrochemical sensing platform for detecting gallic acid (GA). The N-CNTs@ZIF-67 modified glass carbon electrode (GCE) demonstrated high sensitivity for GA electrochemical detection (LOD: 10.

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Background: Central venous catheters (CVCs) are placed where the vena cava meets the right atrium. Their common use raises the risk of catheter-related thrombosis (CRT), a potentially life-threatening complication.

Aim: This study leverages machine learning to develop a CRT predictive model for abdominal surgery patients, aiming to refine clinical decisions and elevate treatment quality.

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Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with limited treatment efficacy despite advances in immune checkpoint blockade (ICB) therapy. The inherently weak immune responses in HCC necessitate novel strategies to improve anti-tumor immunity and synergize with ICB therapy. Kinesin family member 20A (KIF20A) is a tumor-associated antigen (TAA) overexpressed in HCC, and it could be a promising target for vaccine development.

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This study established an animal model of comorbid depression and insomnia by combining chronic unpredictable mild stress (CUMS) with sleep deprivation (SD). The pathogenesis of comorbid depression and insomnia may be associated with impaired AMPK/FOXO3a signaling, which mediates autophagy inhibition, leading to decreased pineal melatonin secretion. The findings revealed that CUMS + SD rats exhibited more pronounced depression-like behaviors, sleep disorders, increased central oxidative stress, and exacerbated neuroinflammation, accompanied by reduced levels of 5-hydroxytryptophan (5-HT) and melatonin in the pineal gland.

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Globally, there are over 3 million severe cases of influenza each year, leading to up to half a million deaths. This study provides a comprehensive analysis of the current status of children's influenza vaccine research over the past 20 years and explores potential future research trends, including improvements in vaccine coverage and strategies to address vaccine hesitancy. We extracted all research data on children's influenza vaccines from 2004 to 2024 using the Web of Science Core Collection (WOSCC).

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Using a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression combined with insomnia were simulated. The abnormal mitochondrial autophagy signaling caused by the putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) signaling pathway directly affects the normal secretion of melatonin by the pineal gland, which may explain the pathogenesis of depression combined with insomnia. This study aims to explore the depression-like behavior, sleep changes, central oxidative stress response, pineal mitochondrial autophagy damage, melatonin secretion, histopathological changes of the pineal gland, and the expression of Pink1/Parkin signaling-related factors in CUMS+SD rats.

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Article Synopsis
  • - The study aimed to compare dosimetric outcomes of vaginal brachytherapy using two methods: single-channel vaginal cylinder (SCVC) and free-hand interstitial needles (FIN) in treating gynecologic tumors after surgery and external beam radiation therapy.
  • - Out of 22 women treated, both methods achieved similar coverage of the high-risk clinical target volume (HR-CTV), but the FIN technique had better dose distribution and resulted in lower doses to critical organs like the rectum and bladder compared to SCVC.
  • - The findings suggest that the FIN technique is a more effective option for high-dose-rate vaginal brachytherapy in minimizing radiation exposure to surrounding organs while ensuring adequate treatment coverage.
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Gallic acid (GA) has important application value in several fields of foods, medicines, and chemical engineering. However, the excessive intake of GA may cause gastrointestinal discomfort and nerve damage. Herein, an economical room-temperature fabrication strategy was reported for the preparation of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles combined with graphitized and carbonylated carbon nanotubes (GCMCN) networks, which were used to achieve the ultrasensitive electrochemical detection of GA.

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Objective: This study aimed to investigate the relationship between bone metabolism markers, including serum klotho, fibroblast growth factor 23 (FGF23), 25(OH)D3, iPTH, calcium (Ca), and PHOS and the progression of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Additionally, the predictive value of these markers for DKD progression was evaluated.

Methods: This study involved 126 patients with T2DM between May 2021 and March 2023.

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Introduction: Pidanjiangtang (PDJT) is a traditional Chinese medicine formula empirically used to treat impaired glucose tolerance (IGT) based on the "Pidan" theory from the classic ancient book Nei Jing. However, the mechanism of PDJT intervention for IGT remains to be studied.

Objective: This study aims to explore the mechanism of PDJT granules intervention in IGT by integrating gut microbiome and UHPLC-MS untargeted metabolomics.

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A mild and efficient electrochemical protocol for the synthesis of quinazolines through N-H/C(sp)-H coupling of -carbonyl anilines with natural amino acids/amines has been developed. The products quinazolines can easily be isolated in moderate to excellent yields under external chemical oxidant-free conditions. Moreover, this reaction can be safely conducted on gram scale.

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Heterogeneous sulfite-based advanced oxidation process is extremely promising for the removal of various industrial pollutants owing to its generation of multiple reactive oxygen species (ROS), while the unclear mechanism of S(IV) conversion and ROS generation hinder its practical applications. Here, the iron-copper bimetallic was synthesized for potassium pyrosulfate catalysis, which was designed for insight into the mechanism of micropollutant degradation driven by sulfur species conversion. Experimental and theoretical calculations have shown that the reaction process and corresponding mechanisms can be significantly distinguished into three different stages.

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Article Synopsis
  • The Pidanjiangtang (PDJT) formula, based on traditional theories, is used clinically to treat impaired glucose tolerance (IGT) but lacks clarity on its bioactive ingredients and mechanisms.
  • A study was conducted using IGT rats to assess PDJT's therapeutic effects and mechanisms through various tests and proteomic analysis after treatment with different doses.
  • Results showed that PDJT improves glucose metabolism, restores islet function, and influences key proteins and pathways, particularly the JAK2/STAT1 pathway, suggesting its effectiveness in managing IGT.
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Background: Orexin is an excitatory neuropeptide produced in the lateral hypothalamus, playing a role in various physiological functions in humans. There is a growing body of literature on orexins. This paper utilizes CiteSpace software to organize and analyze a significant number of articles on orexin, providing readers with an intuitive overview of research trends and emerging hot topics in this field.

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Remarkable progress has been made in the radical cascade cyclization of heteroaryl- or aryl-tethered alkenes to construct benzene-fused frameworks via the cracking of aryl C-H bonds. In contrast, the radical cascade cyclization of linear dienes through the cracking of vinyl C-H bonds to construct nonbenzene-fused ring frameworks with endocyclic double bonds has significantly lagged behind, and major advances have largely been restricted to the generation of 5-membered heterocycles, such as pyrrolinones. Herein, we report the silver-mediated regioselective sulfonylation-cyclization of linear dienes with sodium sulfinates to form sulfonylated 6- and 7-membered cyclic enamines.

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Borderline personality disorder (BPD) is a complex and severe psychiatric condition characterized by emotional, self-image, behavior, and relational instability. While adult BPD heterogeneity has been extensively studied, the phenomenological borderline personality features (BPFs) in adolescence remain uninvestigated. This study aimed to explore the potentially dynamic causal relationships between BPFs in adolescence and identify the subtypes through cross-lagged panel network (CLPN) analysis.

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Article Synopsis
  • - The study introduces a new algorithm, multimodal image confidence (MMC), designed to improve the accuracy of tumor and organ boundary definition in medical images, which is essential for effective radiation therapy planning.
  • - MMC assigns a confidence measure to each voxel in the region of interest using data from multiple imaging modalities, creating detailed images that highlight both external boundaries and internal features without the need for prior model training.
  • - Evaluations of MMC on numerous cases of nasopharyngeal carcinoma and glioma showed that it accurately delineated lesions and correlated well with manual outline methods, suggesting its broad application for better precision in radiation therapy and other medical imaging tasks.
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Article Synopsis
  • - The study highlights challenges in using MoC and earth-abundant 3D transition metals as catalysts for hydrogen evolution reaction (HER) but presents a solution with a porous Ni/MoC composite catalyst through thermal treatment.
  • - The optimal loading of Ni nanoparticles on the MoC surface significantly enhances the catalyst's performance, with the Ni-40/MoC-17 variant showing superior efficiency in reducing onset overpotential in both acidic and alkaline conditions.
  • - The research confirms the synergistic effect between Ni and MoC, suggesting that this composite can efficiently balance hydrogen adsorption and desorption, paving the way for cost-effective and high-performance catalytic materials for water splitting in diverse pH environments.
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Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage.

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The multi-source stationary CT, where both the detector and X-ray source are fixed, represents a novel imaging system with high temporal resolution that has garnered significant interest. Limited space within the system restricts the number of X-ray sources, leading to sparse-view CT imaging challenges. Recent diffusion models for reconstructing sparse-view CT have generally focused separately on sinogram or image domains.

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