A symbiont fungal effector relocalizes a plastidic oxidoreductase to nuclei to induce resistance to pathogens and salt stress.

The root endophytic fungus Serendipita indica establishes beneficial symbioses with a broad spectrum of plants and enhances host resilience against biotic and abiotic stresses. However, little is known about the mechanisms underlying S. indica-mediated plant protection.

JFK Is a Hypoxia-Inducible Gene That Functions to Promote Breast Carcinogenesis.

Many carcinomas feature hypoxia, a condition has long been associated with tumor progression and poor prognosis, as well as resistance to chemoradiotherapy. Here, we report that the F-box protein JFK promotes mammary tumor initiation and progression in MMTV-PyMT murine model of spontaneous breast cancer. We find that is inducible under hypoxic conditions, in which hypoxia-inducible factor HIF-1α binds to and transcriptionally activates in breast cancer cells.

SCF is functionally linked to obesity and metabolic syndrome.

Dysregulation of lipid metabolism could lead to the development of metabolic disorders. We report here that the F-box protein JFK promotes excessive lipid accumulation in adipose tissue and contributes to the development of metabolic syndrome. JFK transgenic mice develop spontaneous obesity, accompanied by dyslipidemia, hyperglycemia, and insulin resistance, phenotypes that are further exacerbated under high-fat diets.

Factors affecting antimonate bioreduction by sp. AR-2 and sp. AR-3.

Unlabelled: The microbial reduction of antimonate (Sb(v)) to antimonite (Sb(iii)), which forms insoluble Sb compounds, is a promising approach to remove antimony (Sb) from wastewater. Among the bacterial strains capable of reducing Sb(v) via anaerobic respiration that have been isolated to date, sp. AR-2 and sp.

Microbial antimonate reduction and removal potentials in river sediments.

Antimony (Sb), a toxic metalloid, exists mainly as Sb(V) and Sb(III) in the aquatic environment. Sb(V) displays greater solubility and can be reduced to insoluble Sb(III) compounds by microbial activities under anaerobic conditions, thus affecting the environmental fate of Sb. This study was conducted to evaluate the potential of Sb(V) reduction and removal from the aqueous phase by microbial communities existing in river sediments with and without the impact of Sb mining activities.

Isolation and Characterization of Facultative-Anaerobic Antimonate-Reducing Bacteria.

Microbial antimonate (Sb(V)) reduction is a promising approach to remove Sb(V) from wastewater. However, current knowledge regarding microbial Sb(V) reduction is limited to strictly anaerobic conditions. This study was the first to isolate three facultative-anaerobic Sb(V)-reducing bacterial strains from the sludge collected from a wastewater treatment facility in an antimony products plant.

Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis.

Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great importance. We report here that the ubiquitin-specific protease USP43 is physically associated with the chromatin remodeling NuRD complex and catalyzes H2BK120 deubiquitination.

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component.

Background: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in melanoma carcinogenesis is still not fully understood.

Methods: We characterized JMJD6 expression in melanoma tissue array by immunohistochemistry analysis.

ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin.

EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor.

A novel magnetic nanoscaled FeO/CeO composite prepared by oxidation-precipitation process and its application for degradation of orange G in aqueous solution as Fenton-like heterogeneous catalyst.

In this work, magnetic nanoparticles (MNPs) FeO/CeO were firstly synthesized using three different preparation methods, including coprecipitation, impregnation oxidation-precipitation and impregnation reduction-precipitation, respectively. The catalytic activities of FeO/CeO MNPs, prepared by above three methods, were compared systematically in terms of the degradation of orange G (OG). The impregnation oxidation-precipitation process was economical and maneuverable due to the usage of air, no need of nitrogen protection and higher utilization efficiency of iron.