Publications by authors named "Ziqun Han"
Article Synopsis
- This study examines the impact of inflammation (neutrophils) and nutrition (albumin) on the mortality of patients undergoing peritoneal dialysis (PD).
- Researchers analyzed data from 1,229 PD patients and found that those with a high neutrophil percentage-to-albumin ratio (NPAR) faced a significantly greater risk of all-cause and cardiovascular disease mortality during a median follow-up of over 34 months.
- Although high NPAR indicates increased mortality risk, the study suggests that it may not be a superior predictor compared to examining neutrophil and albumin levels individually.
Objective: To determine if prodrug conversion of fluorocytosine to fluorouracil by an engineered herpes virus, OncoVEX(GALV/CD), enhances oncolytic therapy of head and neck squamous cell carcinoma.
Design: We assessed the ability of OncoVEX(GALV/CD) and OncoVEX(GFP) to infect, replicate within, and lyse 4 head and neck squamous cell carcinoma lines in vitro. The effects of adding fluorocytosine with OncoVEX(GALV/CD) were evaluated.
We have previously developed an oncolytic herpes simplex virus-1 based on a clinical virus isolate, which was deleted for ICP34.5 to provide tumor selected replication and ICP47 to increase antigen presentation as well as tumor selective virus replication. A phase I/II clinical trial using a version of this virus expressing granulocyte macrophage colony-stimulating factor has shown promising results.
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