Publications by authors named "Ziqiong Wang"

Background: Triple-negative breast cancer (TNBC) is characterized by its rapid progression and aggressive nature, with limited effective therapeutic interventions currently available. Cyclovirobuxine D (CVB-D), a natural alkaloid extracted from the traditional Chinese herb Buxus sinica, is renowned for its cardioprotective and anti-ischemic effects, demonstrating notable anti-cancer properties. Nevertheless, the anti-tumor effects of CVB-D on TNBC remain unverified.

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Background: The local field potential (LFP) signals are a vital signal for studying the mechanisms of deep brain stimulation (DBS) and constructing adaptive DBS containing information related to the motor symptoms of Parkinson's disease (PD).

Objective: A Parkinson's disease state identification algorithm based on the feature extraction strategy of transfer learning was proposed.

Methods: The algorithm uses continuous wavelet transform (CWT) to convert one-dimensional LFP signals into two-dimensional gray-scalogram images and color images respectively, and designs a Bayesian optimized random forest (RF) classifier to replace the three fully connected layers for the classification task in the VGG16 model, to realize automatic identification of the pathological state of PD patients.

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Article Synopsis
  • * Nrf2 plays a vital role in reducing inflammation and oxidative stress, and its inhibition leads to worse inflammatory responses during renal IRI, as evidenced by increased NF-κB signaling activity.
  • * The study found that activating Nrf2 can reduce M1 macrophage polarization and mitigate the severity of renal IRI, suggesting that promoting Nrf2 activity could be a promising treatment strategy.
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Solar-light-driven reduction of CO into renewable fuels has great potential in the production of sustainable energy, addressing the energy crisis and environmental problems simultaneously. However, it is a significant challenge to achieve high selectivity for the conversion of CO into CH, which is a type of fuel with a high calorific value. Herein, carbon quantum dots (CQDs) were integrated with an oxygen vacancy modified nickel-based metal organic frameworks (NiMOFs) to form the CQDs-X/NiMOF series, which exhibited superior performance for CO photoreduction into CH compared with pure NiMOFs in the presence of hole scavengers under visible light irradiation.

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Lecithin:retinol acyltransferase (LRAT) is the main enzyme producing retinyl esters (REs) in quiescent hepatic stellate cells (HSCs). When cultured on stiff plastic culture plates, quiescent HSCs activate and lose their RE stores in a process similar to that in the liver following tissue damage, leading to fibrosis. Here we validated HSC cultures in soft gels to study RE metabolism in stable quiescent HSCs and investigated RE synthesis and breakdown in activating HSCs.

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As the primary component of anti-tumor immunity, T cells are prone to exhaustion and dysfunction in the tumor microenvironment (TME). A thorough understanding of T cell exhaustion (TEX) in the TME is crucial for effectively addressing TEX in clinical settings and promoting the efficacy of immune checkpoint blockade therapies. In eukaryotes, numerous cell surface proteins are tethered to the plasma membrane via Glycosylphosphatidylinositol (GPI) anchors, which play a crucial role in facilitating the proper translocation of membrane proteins.

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Background: Previous studies have shown social activity is associated with reduced risk of health outcomes. However, among older people (≥65 years) who were socially inactive at baseline, limited study explored whether increased participation in social activity in later life was associated with reduced risk of health outcomes; therefore, using the data from the Chinese Longitudinal Healthy Longevity Survey, the study was performed.

Methods: The study outcomes were 10-year all-cause mortality (sample number = 9,984) and 10-year heart diseases (sample number = 7,496).

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Objective: Social residents become increasingly concerned about Alzheimer's dementia (AD) as a global public health crisis. China's AD population is the largest and growing fastest. However, no study has examined Chinese social residents' knowledge and attitudes concerning Alzheimer's illness.

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Inflammation, apoptosis and oxidative stress play crucial roles in the deterioration of severe acute pancreatitis-associated acute respiratory distress syndrome (SAP-ARDS). Unfortunately, despite a high mortality rate of 45 %[1], there are limited treatment options available for ARDS outside of last resort options such as mechanical ventilation and extracorporeal support strategies[2]. This study investigated the potential therapeutic role and mechanisms of AQP9 inhibitor RG100204 in two animal models of severe acute pancreatitis, inducing acute respiratory distress syndrome: 1) a sodium-taurocholate induced rat model, and 2) and Cerulein and lipopolysaccharide induced mouse model.

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Background: Hypertension and frailty often coexist in older people. The present study aimed to evaluate the association of frailty status with overall survival in elderly hypertensive patients, using data from the Chinese Longitudinal Healthy Longevity Survey.

Methods: A total of 10,493 elderly hypertensive patients were included in the present study (median age 87.

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Background: α-1,3-mannosyltransferase (ALG3) holds significance as a key member within the mannosyltransferase family. Nevertheless, the exact function of ALG3 in cancer remains ambiguous. Consequently, the current research aimed to examine the function and potential mechanisms of ALG3 in various types of cancer.

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Background: The functional relevance of cyclic adenosine monophosphate (cAMP)-response element-binding protein 5 (CREB5) in cancers remains elusive, despite its significance as a member of the CREB family. The current research aims to explore the role of CREB5 in multiple cancers.

Methods: Pan-cancer analysis was performed to explore the expression patterns, prognostic value, mutational landscape as well as single-cell omic, immunologic, and drug sensitivity profiles of CREB5.

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NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.

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Background: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to drug therapy in various cancers remains unclear.

Methods: First, the expression, prognostic value, and genetic and epigenetic alterations of lactylation genes were systematically explored in a pan-cancer manner.

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Parkinson's disease patients have early vocal cord damage, and their voiceprint characteristics differ significantly from those of healthy individuals, which can be used to identify Parkinson's disease. However, the samples of the voiceprint dataset of Parkinson's disease patients are insufficient, so this paper proposes a double self-attention deep convolutional generative adversarial network model for sample enhancement to generate high-resolution spectrograms, based on which deep learning is used to recognize Parkinson's disease. This model improves the texture clarity of samples by increasing network depth and combining gradient penalty and spectral normalization techniques, and a family of pure convolutional neural networks (ConvNeXt) classification network based on Transfer learning is constructed to extract voiceprint features and classify them, which improves the accuracy of Parkinson's disease recognition.

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Article Synopsis
  • The study investigates how changes in frailty status affect all-cause mortality and cardiovascular deaths in older adults using data from the Chinese Longitudinal Healthy Longevity Survey.
  • It analyzes data from 2,805 participants over two time periods (2011 and 2014) and categorizes them into four frailty status groups to determine the associated risks.
  • Results show that individuals who improved in frailty status had significantly lower mortality rates, especially those who maintained robustness, highlighting the importance of frailty transitions in health outcomes for older populations.
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Introduction: The high incidence of breast cancer (BC) prompted us to explore more factors that might affect its occurrence, development, treatment, and also recurrence. Dysregulation of cholesterol metabolism has been widely observed in BC; however, the detailed role of how cholesterol metabolism affects chemo-sensitivity, and immune response, as well as the clinical outcome of BC is unknown.

Methods: With Mendelian randomization (MR) analysis, the potential causal relationship between genetic variants of cholesterol and BC risk was assessed first.

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Introduction: Hypertension increases the risk of cardiovascular disease. Uncontrolled nocturnal blood pressure is prevalent in patients taking antihypertensive medication, with an incidence rate of 30-60%. Although chronotherapy with antihypertensive agents may provide a new direction for effective control of nocturnal blood pressure, the clinical evidence base remains controversial.

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Background: Albumin to fibrinogen ratio (AFR), a new inflammatory marker, has emerged as a useful indicator to predict adverse outcomes for several diseases. However, whether AFR could be a new useful indicator to predict mortality in HCM patients remains to be evaluated. The study explored the predictive value of AFR for HCM-related death in adult HCM patients.

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Article Synopsis
  • - Sialylation, which is the process of synthesizing sialic acid glycans, significantly influences cancer progression, immune evasion, and treatment resistance, though its impact on patient outcomes and tumor environments is still not well understood.
  • - A study assessed sialylation-related gene expressions and their prognostic implications across various cancer types, revealing that tumors generally exhibit altered sialylation and that higher sialylation scores correlate with poorer outcomes, particularly in uveal melanoma and pancreatic adenocarcinoma.
  • - The findings suggest that sialylation scores are associated with immune cell infiltration and responsiveness to immunotherapy, indicating they could serve as valuable biomarkers for cancer prognosis and treatment strategies.
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Zinc (Zn) is an important trace element in the human body and plays an important role in growth, development, and male reproductive functions. Marginal zinc deficiency (MZD) is common in the human population and can cause spermatogenic dysfunction in males. Therefore, the aim of this study was to investigate methods to improve spermatogenic dysfunction caused by MZD and to further explore its mechanism of action.

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Introduction: This study aims to explore the mortality risk in older people who drank alcohol in the past by varying the duration of alcohol abstention.

Methods: In total, 31,999 participants aged ≥65 years from the Chinese Longitudinal Healthy Longevity Survey (Waves 1998, 2000, 2002, 2005, 2008, 2011, 2014) were included. Duration of alcohol abstention was assessed by designed questions, and the study outcome was all-cause mortality.

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Article Synopsis
  • Nucleosome assembly protein 1 (NAP1) is a key molecular chaperone for histone H2A-H2B, but its function in wheat has not been extensively studied.
  • Researchers conducted a genome-wide analysis and qRT-PCR to explore the expression of TaNAP1 genes in response to hormonal and viral stresses.
  • Findings indicated that TaNAP1 is more highly expressed in tissues with strong growth potential, like roots, and may play a role in plant defense against viruses, setting the stage for future research.
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Objective: A new inflammatory marker, namely monocyte-to-high-density lipoprotein cholesterol ratio (MHR), has emerged as a useful indicator for adverse outcomes in several cardiovascular diseases; however, the relationship between MHR and the prognosis of hypertrophic cardiomyopathy (HCM) remains to be evaluated. We examined the relationship between MHR and all-cause mortality (ACM) in Chinese adult patients with HCM.

Methods: We retrospectively performed clinical evaluation in 305 patients with HCM (median age: 52.

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Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it. Hypertension is a condition that is named after its clinical features.

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