Orientation-independent quantification of macromolecular proton fraction in tissues with suppression of residual dipolar coupling.

Quantitative magnetization transfer (MT) imaging enables noninvasive characterization of the macromolecular environment of tissues. However, recent work has highlighted that the quantification of MT parameters using saturation radiofrequency (RF) pulses exhibits orientation dependence in ordered tissue structures, potentially confounding its clinical applications. Notably, in tissues with ordered structures, such as articular cartilage and myelin, the residual dipolar coupling (RDC) effect can arise owing to incomplete averaging of dipolar-dipolar interactions of water protons.

An efficient C-glycoside production platform enabled by rationally tuning the chemoselectivity of glycosyltransferases.

Despite the broad potential applications of C-glycosides, facile synthetic methods remain scarce. Transforming glycosyltransferases with promiscuous or natural O-specific chemoselectivity to C-glycosyltransferases is challenging. Here, we employ rational directed evolution of the glycosyltransferase MiCGT to generate MiCGT-QDP and MiCGT-ATD mutants which either enhance C-glycosylation or switch to O-glycosylation, respectively.

Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of -Amplified Breast Cancer.

amplification occurs in breast cancer and currently lacks effective therapies. PKMYT1 as a synthetic lethal target for amplification holds promise for the treatment of -amplified breast cancer. Herein, we discover a series of 2-amino-[1,1'-biphenyl]-3-carboxamide derivatives as potent and selective PKMYT1 inhibitors using structure-based drug design.

Effect of liver abnormalities on mortality in Fontan patients: a systematic review and meta-analysis.

Background: Fontan-associated liver disease (FALD) is one of the most common complications following Fontan procedure, but the impact of FALD on survival outcomes remains controversial. The aim of this systematic review and meta-analysis was to examine and quantify the influence of liver disease on the survival of Fontan patients.

Methods: The Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed, and relevant human studies published from inception up to 12 August 2022 were searched.

Integrative metabolomics dictate distinctive signature profiles in patients with Tetralogy of Fallot.

Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CCHD) with multifactorial etiology. We aimed to investigate the metabolic profiles of CCHD and their independent contributions to TOF.

Methods: A cohort comprising 42 individuals with TOF and atrial septal defect (ASD) was enrolled.

Recyclable FeO@UiO-66-PDA core-shell nanomaterials for extensive metal ion adsorption: Batch experiments and theoretical analysis.

With the ever-increasing challenge of heavy metal pollution, the imperative for developing highly efficient adsorbents has become apparent to remove metal ions from wastewater completely. In this study, we introduce a novel magnetic core-shell adsorbent, FeO@UiO-66-PDA. It features a polydopamine (PDA) modified zirconium-based metal-organic framework (UiO-66) synthesized through a simple solvothermal method.

Edge-sharing bi-octahedral diruthenium(IV,IV) compounds containing Ru-Ru bonds chelated and bridged by two carbonate and two oxo groups.

From paddle-wheel starting material NaRu(CO)·6HO, a family of edge-sharing bi-octahedral (ESBO) diruthenium(IV,IV) compounds formulated as RuO(CO)(HO)L·HO [L = piperazine (1) or 2-methylpiperazine (2), = 4, and L = 2,2-dimethylpiperazine (3), = 12] and RuO(CO)(OH){M(HO)}·HO [M = Mg (4), = 4, and Ni (5), = 2] were prepared and structurally characterized. The Ru dimer is chelated and bridged by two CO and two μ-O in a manner, and the Ru-Ru distances fall in the range 2.3808(6)-2.

Right ventricular dilatation score: a new assessment to right ventricular dilatation in adult patients with repaired tetralogy of Fallot.

Background: Patients with repaired tetralogy of Fallot (rTOF) experience long-term chronic pulmonary valve regurgitation resulting in right ventricular (RV) dilatation. According to current guidelines, the evaluation of patients with rTOF for RV dilatation should be based on cardiac magnetic resonance (CMR). However, for many asymptomatic patients, routine CMR is not practical.

Excellent capture of Pb(II) and Cu(II) by hierarchical nanoadsorbent FeO@SiO@PAA-SOH: A combined experimental and theoretical study.

A novel magnetic nanoadsorbent (FeO@SiO@PAA-SOH) was synthesized by grafting acrylic acid and sulfonic group to FeO@SiO using a facile cross-link technology. The adsorbent presented water-stability and biocompatibility in wastewater, which exhibited high-selectivity capture for Pb(II) and Cu(II) of 182.5 mg/g and 250.

TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation.

Background: Trimethylamine-N-oxide (TMAO) has been shown to be an important player in cardiovascular disease (CVD) by promoting vascular inflammation and endothelial dysfunction. We recently found that exosomes (Exos) released from TMAO-activated hepatocytes (TMAO-Exos) could significantly induce inflammation and endothelial dysfunction. However, understandings of how are the Exos secreted by hepatocytes, where are they distributed , and what effects will they have on vascular inflammation remain limited.

A Comparison Study of the Effect on IBS-D Rats among Ginger-Partitioned Moxibustion, Mild Moxibustion, and Laser Moxibustion.

Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder that severely affects patients' life. Moxibustion is believed to be an effective way to treat IBS-D. However, the therapeutic effects and the underlying mechanisms in symptom management of IBS-D by different moxibustion therapies remain unclear.

Structural, spectroscopic and electronic properties of a family of face-shared bi-octahedral Ru complexes with a bridging 2,5-di(2-pyridyl)pyrrolide ligand.

A family of Ru2 dimers, [Ru2(μ-κ2N,N':κ2N',N''-dpp)2(μ-X)(X)2]q+ (X = Cl, Br, q = 0 and X = I, q = 1) is synthesized from a [Ru2(OAc)4Cl] paddlewheel starting material. The neutral products are mixed-valence Ru25+ dimers with a Ru-Ru bond order of 0.5, while the cationic iodide is a Ru26+ dimer with formal bond order of 1.

Enhancing magnetic hardness by sonication assisted synthesis of heterometallic carbonato spin-glass Na[Ni(HO)Ru(CO)]·3HO.

Control of magnetic performances of molecular magnets is essential but few efforts have been documented. A green and efficient sonication assisted synthesis of a new heterometallic diruthenium(ii,iii) carbonate, Na[Ni(H2O)4Ru2(CO3)4]·3H2O (1), was carried out by self-assembling in aqueous solution. Compound 1 exhibits spin-glass behavior below ∼5.

Lipoxin A inhibited the activation of hepatic stellate cells -T6 cells by modulating profibrotic cytokines and NF-κB signaling pathway.

Background: The deposition of extracellular matrix (ECM) during hepatic fibrosis is an intermediate process in the progression of multiple chronic liver diseases to cirrhosis. Because activated hepatic stellate cells (HSCs) are the main source of ECM, HSCs activation is the central link in the formation of liver fibrosis. It was reported that the analogs of lipoxin A (LXA) had anti-fibrotic effects, but the mechanisms are still not clear.

Alkali counterions tune diruthenium(iii,iii)-based ferrimagnetic chain structured antiferromagnets exhibiting step-like hysteresis loops.

The synthesis of antiferromagnets (AFMs) has attracted extensive attention in the area of magnetic devices, such as spintronics and memory devices. Following our initial work on the employment of the homo-valent diruthenium(iii,iii) paddle wheel species with high spin states (S = 2) as building blocks and active components for the construction of molecule-based magnetic materials, the reaction of mixed-valent diruthenium(ii,iii) phosphates Ru(HPO)(HPO)(HO)·2HO (1) with HO, Cu and ACl (A = K, Rb and Cs) in aqueous solution led to the formation of heterometallic copper diruthenium(iii,iii) phosphates A[Cu(HO)Ru(HPO)(PO)(HO)]·nHO [A = K (2); A = Rb and n = 2 (3); A = Cs and n = 3 (4)]. The compounds consist of chain structures in which each octahedral environment of Cu(HO) bonds to two [Ru(HPO)(PO)] units in a trans manner, forming a ferrimagnetic negative chain {Cu(HO)Ru(HPO)(PO)(HO)}, exhibiting anomalous magnetic properties.

Analysis of EEG records in an epileptic patient using wavelet transform.

About 1% of the people in the world suffer from epilepsy and 30% of epileptics are not helped by medication. Careful analyses of the electroencephalograph (EEG) records can provide valuable insight and improved understanding of the mechanisms causing epileptic disorders. Wavelet transform is particularly effective for representing various aspects of non-stationary signals such as trends, discontinuities, and repeated patterns where other signal processing approaches fail or are not as effective.