Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression.

This study aimed to assess the impact of conditioned medium from epidermal neural crest stem cells (EPI-NCSCs-CM) on functional recovery following spinal cord injury (SCI), while also exploring the involvement of the PI3K-AKT signaling pathway in regulating neuronal apoptosis. EPI-NCSCs were isolated from 10-day-old Sprague-Dawley rats and cultured for 48 h to obtain EPI-NCSC-CM. SHSY-5Y cells were subjected with HO treatment to induce apoptosis.

Synergistic Phototherapy-Molecular Targeted Therapy Combined with Tumor Exosome Nanoparticles for Oral Squamous Cell Carcinoma Treatment.

Oral squamous cell carcinoma (OSCC) contributes to more than 90% of all oral malignancies, yet the performance of traditional treatments is impeded by limited therapeutic effects and substantial side effects. In this work, we report a combinational treatment strategy based on tumor exosome-based nanoparticles co-formulating a photosensitizer (Indocyanine green) and a tyrosine kinase inhibitor (Gefitinib) (IG@EXOs) for boosting antitumor efficiency against OSCC through synergistic phototherapy-molecular targeted therapy. The IG@EXOs generate distinct photothermal/photodynamic effects through enhanced photothermal conversion efficiency and ROS generation, respectively.

Upregulation of circ0000381 attenuates microglial/macrophage pyroptosis after spinal cord injury.

Neuroinflammation exacerbates secondary damage after spinal cord injury, while microglia/macrophage pyroptosis is important to neuroinflammation. Circular RNAs (circRNAs) play a role in the central nervous system. However, the functional role and mechanism of circRNAs in regulating microglia/macrophage pyroptosis after spinal cord injury are still poorly studied.

Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis.

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury. However, whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains unclear. In the present study, we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem cells.

Regulation of Impedance Matching and Dielectric Loss Properties of N-Doped Carbon Hollow Nanospheres Modified With Atomically Dispersed Cobalt Sites for Microwave Energy Attenuation.

The rational design of lightweight, broad-band, and high-performance microwave absorbers is urgently required for addressing electromagnetic pollution issue. Metal single atoms (M-SAs) absorbers receive considerable interest in the field of microwave absorption due to the unique electronic structures of M-SAs. However, the simultaneous engineering of the morphology and electronic structure of M-SAs based absorbers remains challenging.

NiO/Ni Heterojunction on N-Doped Hollow Carbon Sphere with Balanced Dielectric Loss for Efficient Microwave Absorption.

Hollow carbon spheres are potential candidates for lightweight microwave absorbers. However, the skin effect of pure carbon-based materials frequently induces a terrible impedance mismatching issue. Herein, small-sized NiO/Ni particles with heterojunctions on the N-doped hollow carbon spheres (NHCS@NiO/Ni) are constructed using SiO as a sacrificing template.

Near Field Communication-based Agricultural Management Service Systems for Family Farms.

This paper presents an agricultural management service system that aims to meet the needs of Internet of Things (IoT) information upgrades in China's family farms. The proposed agricultural management service system consists of Near Field Communication (NFC) tags, in-field service nodes, and smartphones. NFC tags are used as the core identifier of various agricultural management elements.

Mixed Two-Dimensional Organic-Inorganic Halide Perovskites for Highly Efficient and Stable Photovoltaic Application.

Solar cells made of hybrid organic-inorganic perovskite (HOIP) materials have attracted ever-increasing attention due to their high efficiency and easy fabrication. However, issues regarding their poor stability remain a challenge for practical applications. Engineering the composition and structure of HOIP can effectively enhance the thermal stability and improve the power conversion efficiency (PCE).

Magnesiation of pyridine N-oxides via iodine or bromine-magnesium exchange: a useful tool for functionalizing pyridine N-oxides.

Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl x LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.