Publications by authors named "Zipporah N Bukania"
Many statistical models have been proposed in the literature for the analysis of longitudinal data. One may propose to model two or more correlated longitudinal processes simultaneously, with a goal of understanding their association over time. Joint modeling is then required to carefully study the association structure among the outcomes as well as drawing joint inferences about the different outcomes.
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- - Cross-over designs in clinical trials allow researchers to compare treatments within the same subjects, providing more precise estimates of efficacy, especially for new drugs.
- - A recent study analyzed a new piecewise linear mixed-effects (PLME) model against traditional models—Grizzle's mixed-effects (GME) and Jones & Kenward's mixed-effects (JKME)—to evaluate their performance in analyzing cross-over trial data.
- - Results indicated that the PLME model outperformed the GME and JKME models in estimating variance-covariance parameters and achieved better model convergence, confirming the hypothesis that high-dose iodine salt significantly lowers diastolic blood pressure (DBP).
Diet is one of the modifiable lifestyle factors in management of kidney disease. We explored perceptions on adherence to dietary prescriptions for adults with chronic kidney disease on hemodialysis. This was a qualitative descriptive study.
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- Machakos and Makueni counties in Kenya face challenges related to land degradation, climate change, and food insecurity, impacting both women and children's dietary health.
- A study involving 277 woman-child pairs found no significant differences in food security or dietary diversity between lower midland agroecological zones LM4 and LM5.
- The research highlighted that severe food insecurity is linked to poor nutritional status in children, particularly older ones, indicating that a simple dietary diversity score could underestimate food insecurity in semi-arid regions.
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- Key risk factors for metabolic syndrome identified include raised blood pressure, increased waist circumference, and low HDL cholesterol, while issues like raised fasting glucose and triacylglycerides appear less frequently.
- The research highlights the need for greater awareness and preventive strategies from the Kenyan government, along with longitudinal studies to better understand the causes of metabolic syndrome in the country.