Early-life ozone exposure and childhood otitis media: Unveiling critical windows of risk.

Background: Despite increasing evidence of a strong correlation between air pollution and otitis media (OM), the impact of early-life ozone (O) exposure on the development of OM in children remains uncertain.

Objectives: To explore the connection between early-life O exposure and OM, and to identify the critical time period(s) during which O exposure significantly influences the development of OM in children.

Methods: We conducted a study involving 8689 children living in Changsha, China.

Childhood Helicobacter pylori infection: Impacts of environmental exposures and parental stress.

Background: Helicobacter pylori infection (HPI) is extremely common in the world, particularly in less developed areas, but the primary causes of childhood HPI are unspecified.

Objectives: To determine the influences of exposure to home environmental factors (HEFs), outdoor air pollutants (OAPs), and parental stress (PS), as well as their interactions on children's HPI.

Methods: We implemented a retrospective cohort study with 8689 preschoolers from nine districts at Changsha, China, was conducted using questionnaires to collect data of health and HEFs.

High humidity and NO co-exposure exacerbates allergic asthma by increasing oxidative stress, inflammatory and TRP protein expressions in lung tissue.

Allergic asthma is a chronic inflammatory airway disease with a high mortality rate and a rapidly increasing prevalence in recent decades that is closely linked to environmental change. Previous research found that high humidity (HH) and the traffic-related air pollutant NO both aggregated allergic asthma. Their combined effect and mechanisms on asthma exacerbation, however, are unknown.

Combined exposure of polystyrene microplastics and benzo[a]pyrene in rat: Study of the oxidative stress effects in the liver.

Microplastics (MPs) and benzo[a]pyrene (B[a]P) are prevalent environmental pollutants. Numerous studies have extensively reported their individual adverse effects on organisms. However, the combined effects and mechanisms of exposure in mammals remain unknown.

Serum-based ATR-FTIR spectroscopy combined with multivariate analysis for the diagnosis of pre-diabetes and diabetes.

Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence that is causing worldwide concern. The pre-diabetes stage is the only reversible stage in the patho-physiological process towards DM. Due to the limitations of traditional methods, the diagnosis and detection of DM and pre-diabetes are complicated, expensive, and time-consuming.

Effects of pre-natal and post-natal exposures to air pollution on onset and recurrence of childhood otitis media.

Background: Despite mounting evidence linking outdoor air pollution with otitis media (OM), the role of air pollutant(s) exposure during which critical window(s) on childhood OM remains unknown.

Objectives: We sought to identify the key air pollutant(s) and critical window(s) associated with the onset and recurrent attacks of OM in kindergarten children.

Methods: A combined cross-sectional and retrospective cohort study involving 8689 preschoolers aged 3-6 years was performed in Changsha, China.

Tamoxifen resistance-related ceRNA network for breast cancer.

Tamoxifen (TMX) is one of the most widely used drugs to treat breast cancer (BC). However, acquired drug resistance is still a major obstacle to its application, rendering it crucial to explore the mechanisms of TMX resistance in BC. This aims of this study were to identify the mechanisms of TMX resistance and construct ceRNA regulatory networks in breast cancer.

Whole transcriptome sequencing and competitive endogenous RNA regulation network construction analysis in benzo[a]pyrene-treated breast cancer cells.

Breast cancer is the most common malignant tumor in women worldwide, and environmental pollutants are considered to be risk factors. Currently, most studies into benzo[a]pyrene (B[a]P)-induced breast cancer focus on biological effects such as proliferation, invasion, and metastasis, DNA damage, estrogen receptor (ER)-related molecular mechanisms, oxidative damage, and other metabolic pathways. This study aims to provide insights into the role of B[a]P in breast cancer development through RNA-seq and bioinformatics analysis and construction of a competing endogenous RNA (ceRNA) regulatory network.

Evaluation of acute toxicity response to the algae Chlorella pyrenoidosa of biosynthetic silver nanoparticles catalysts.

Biosynthetic of silver nanoparticles (AgNPs) by using fungi has attracted much attention due to its high catalytic efficiency and environmentally friendly characteristic. However, a few studies have focused on the ecological toxicity effects of biogenic AgNPs on algae. Here, we first investigated the catalytic reduction of 4-nitrophenol (4-NP) by WZ07-AgNPs biosynthesized by Letendraea sp.

The complete chloroplast genome of (Asteraceae).

L. is an important Chinese medicinal plant. In this study, we reported the complete chloroplast genome of .