T1rho MRI relaxation in knee OA subjects with varying sizes of cartilage lesions.

Background: The purpose of this investigation is to evaluate the T(1ρ) relaxation times of articular cartilage surrounding focal defects in the tibiofemoral joint.

Methods: Quantitative cartilage assessment was performed using 3T MRI with T(1ρ) mapping in 19 healthy individuals and 44 OA patients. Sagittal T2-weighted fast spin echo (FSE) images were acquired for lesion assessment.

Effects of endurance training on cardiorespiratory fitness and substrate partitioning in postmenopausal women.

We examined the effect of endurance training on energy substrate partitioning during rest and exercise in postmenopausal women. Ten healthy sedentary (55 +/- 1 years old) subjects completed 12 weeks of endurance exercise training on a cycle ergometer (5 d/wk, 1 h/d, 65% peak oxygen consumption [Vo(2)peak]). Whole-body energy substrate oxidation was determined by indirect calorimetry during 90 minutes of rest and 60 minutes of cycle ergometer exercise.

Training improves the response in glucose flux to exercise in postmenopausal women.

We examined the effects of endurance training on parameters of glucose flux during rest and exercise in postmenopausal women. Ten sedentary, but healthy women (55 +/- 1 yr) completed 12 wk of endurance exercise training on a cycle ergometer [5 days/wk, 1 h/day, 65% peak oxygen consumption (Vo(2peak))]. Flux rates were determined by primed continuous infusion of [6,6-(2)H]glucose (D(2)-glucose) during 90 min of rest and 60 min of cycle ergometer exercise during one pretraining exercise trial [65% Vo(2peak) (PRE)] and two posttraining exercise trials [the power output that elicited 65% pretraining Vo(2peak) (ABT) and 65% posttraining Vo(2peak) (RLT)].