Publications by authors named "Zini Jian"

Article Synopsis
  • - Fluorescence in Situ Hybridization (FISH) is a method for identifying macromolecules using DNA or RNA probes with fluorescent tags, allowing visualization of specific sequences in cells through microscopy.
  • - The analysis of FISH images is challenging due to the large number of cells and complex nucleic acid arrangements, often requiring time-consuming manual processing that can lead to errors.
  • - The proposed solution integrates medical imaging with deep learning to create an automated system that quickly detects fluorescent spots, outperforming traditional models like YOLO in accuracy, which is important for assessing cellular traits in cancer diagnosis.
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Fluorescence in situ hybridization (FISH) is a powerful cytogenetic method used to precisely detect and localize nucleic acid sequences. This technique is proving to be an invaluable tool in medical diagnostics and has made significant contributions to biology and the life sciences. However, the number of cells is large and the nucleic acid sequences are disorganized in the FISH images taken using the microscope.

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In recent years, the incidence of cerebrovascular diseases (CVD) is increasing, which seriously endangers human health. The study on hemodynamics of cerebrovascular disease can help us to understand, prevent, and treat the disease. As one of the important parameters of human cerebral hemodynamics and tissue metabolism, OEF (oxygen extraction fraction) is of great value in central nervous system diseases.

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The acquisition of functional magnetic resonance imaging (fMRI) images of blood oxygen level-dependent (BOLD) effect and the signals to be analyzed is based on weak changes in the magnetic field caused by small changes in blood oxygen physiological levels, which are weak signals and complex in noise. In order to model and analyze the pathological and hemodynamic parameters of BOLD-fMRI images effectively, it is urgent to use effective signal analysis techniques to reduce the interference of noise and artifacts. In this paper, the noise characteristics of functional magnetic resonance imaging and the traditional signal denoising methods are analyzed.

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Background: Clinically, doctors obtain the left ventricular posterior wall thickness (LVPWT) mainly by observing ultrasonic echocardiographic video stream to capture a single frame of images with diagnostic significance, and then mark two key points on both sides of the posterior wall of the left ventricle with their own experience for computer measurement. In the actual measurement, the doctor's selection point is subjective, and difficult to accurately locate the edge, which will bring errors to the measurement results.

Methods: In this paper, a convolutional neural network model of left ventricular posterior wall positioning was built under the TensorFlow framework, and the target region images were obtained after the positioning results were processed by non-local mean filtering and opening operation.

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Synopsis of recent research by authors named "Zini Jian"

  • - Zini Jian's research primarily focuses on innovative applications of image processing and machine learning in medical diagnostics, including the segmentation of fluorescent images and the enhancement of neuroimaging data analysis.
  • - The investigations include the development of an improved Nested U-Net network for efficient segmentation of FISH images, aimed at accurately detecting nucleic acid sequences despite crowded cellular environments.
  • - Additionally, Jian has contributed to the understanding of human brain oxygen extraction through reviews of MRI techniques and has worked on denoising BOLD-fMRI data using Bayesian estimation, showcasing advancements in both cerebrovascular health research and functional imaging methodologies.