Room-Temperature CuI-Catalyzed -Arylation of Cyclopropylamine.

A general and efficient CuI/-carbazolyl-1-pyrrole-2-carbohydrazide catalyst system was developed for the -arylation of cyclopropylamine using aryl bromides at room temperature. Herein, 5 mol % CuI and 5 mol % of the ligand were used to synthesize -aryl cyclopropylamines in moderate to excellent yields. This protocol was scaled up to produce the desired product at gram levels and has been generalized for C-N coupling between aryl bromides and amines at room temperature.