A multi-center blinded prospective study of urine neural thread protein measurements in patients with suspected Alzheimer's disease.

Objective: To investigate the utility of a clinical laboratory ELISA format assay that measures neural thread protein (NTP) in urine in the assessment of patients presenting with cognitive symptoms.

Design: A prospective blinded multicentered study.

Setting: Eight US specialty clinics for the evaluation of cognitive or memory disorder or dementia, including memory disorder and dementia clinics, neurology clinics, and psychiatry clinics, in 8 states.