Publications by authors named "Zinah Majid"
This study aimed to evaluate the cardioprotective effects of ghrelin in septic mice, focusing on its anti-inflammatory and antioxidant properties. Thirty-five male Swiss mice (8-12 weeks old, 23-33g) were randomly assigned to five groups ( = 7 each): (1) Normal, fed usual diets, (2) Sham, subjected to anesthesia and laparotomy, (3) Sepsis, subjected to cecal ligation and puncture, (4) Vehicle, given an equivalent volume of intraperitoneal saline injections immediately after cecal ligation and puncture, and (5) Ghrelin-treated, administered 80 µg/kg ghrelin intraperitoneal injections immediately following cecal ligation and puncture. Serum levels of tumor necrosis factor-alpha (TNF-α), macrophage migration inhibitory factor (MIF), toll-like receptor 4 (TLR4), and 8-epi-prostaglandin F2 alpha (8-epi-PGF2α) were measured.
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- The research investigates the anti-inflammatory effects of ghrelin in mice models suffering from polymicrobial sepsis.
- A total of 35 male albino Swiss mice were randomly split into five groups, with some receiving ghrelin treatment and others undergoing different procedures to induce sepsis or serve as controls.
- Results showed that ghrelin-treated mice had significantly lower levels of inflammatory markers IL-1β, NF-κB, and TLR4 compared to the sepsis and vehicle groups, suggesting that ghrelin has protective effects on cardiac tissue during sepsis.