Global prevalence of internet addiction among university students: a systematic review and meta-analysis.

Purpose Of Review: The prevalence of internet addiction among university students has been extensively studied worldwide, however, the findings have been mixed. This meta-analysis aimed to examine the global prevalence of internet addiction in university students and identify its potential moderators.

Recent Findings: A total of 101 eligible studies, comprising 128,020 participants across 38 countries and territories, were included.

Bending behavior and influence parameter optimization of connection joints of disc-buckle type formwork support.

In order to systematically study the bending behavior of the connection joints of the disc-buckle type formwork support, the accurate numerical model of the disc-buckle type connection joints was obtained through the experimental on the bending behavior of the connection joints of the disc-buckle type, and the bending moment-rotation curve of the joints was verified. The analysis of the failure mode and stress distribution of the joints reveals the importance of the bending behavior of each component. By establishing an accurate numerical model of the joint, the accuracy of the bending experiment of the joint was verified, and the parametric analysis of the influence factors such as the depth of the wedge insertion the disk-plate, the initial position of the wedge insertion the disk-plate, the thickness of the wedge, material constitutive of the wedge and the thickness of the disk-plate was carried out to grasp the influence of the relevant parameters on the bending behavior of the joint.

Thoracolumbar Sagittal Morphology and Segmental Inclination: A Cross-sectional Cohort Study of Asymptomatic Adult Volunteers.

Study Design: A cross-sectional cohort study.

Objective: To present a normative value reference of spinal segmental inclination stratified by age and pelvic incidence (PI), and to clarify the impact of segmental inclination on spinal sagittal morphology.

Summary Of Background Data: Thoracolumbar segmental inclination has been shown to correlate with the clinical outcomes of adult spinal deformity surgery.

Stress-strain characteristics of FRP-PVC confined spontaneous combustion gangue concrete columns.

A total of 40 fiber reinforced polymer (FRP) and polyvinyl chloride (PVC) confined spontaneous combustion gangue coarse-aggregate concrete (SAC) specimens were subjected to axial compression tests and theoretical studies. The main analysis focused on the impact of the replacement rate of spontaneous combustion gangue (SCG), the type of CFRP confinement, and the number of CFRP layers on the axial compression performance of CFRP-PVC confined SAC (CFRP-PVC-SAC). The results show that CFRP-PVC confinement can effectively enhance the axial compressive capacity, axial deformation, and lateral deformation of the components.

Escitalopram-induced QTc prolongation and its relationship with KCNQ1, KCNE1, and KCNH2 gene polymorphisms.

Background: Escitalopram can cause prolongation of the QT interval on the electrocardiogram (ECG). However, only some patients get pathological QTc prolongation in clinic. We investigated the influence of KCNQ1, KCNE1, and KCNH2 gene polymorphisms along with clinical factors on escitalopram-induced QTc prolongation.

Association between the upper instrumented vertebra screw angles and proximal junctional complications in patients with de novo degenerative lumbar scoliosis.

Objective: The aim of this study was to investigate the impact of upper instrumented vertebra (UIV) screw angles on proximal junctional complications in patients with de novo degenerative lumbar scoliosis (DNDLS).

Methods: A total of 120 patients with DNDLS who underwent posterior long-segment instrumentation and fusion were included. Patients were divided into a proximal junctional kyphosis/failure (PJK/PJF) group and a non-PJK/PJF group.

The Role of Thoracic Tilt in Identifying Thoracic Compensation and Predicting Proximal Junctional Kyphosis in Degenerative Lumbar Scoliosis.

Study Design: A retrospective cohort study of consecutive patients.

Objective: To investigate the clinical value of thoracic tilt (TT) in characterizing thoracic compensation and predicting proximal junctional kyphosis (PJK) in degenerative lumbar scoliosis (DLS).

Summary Of Background Data: Thoracic compensation has been shown to be associated with the development of PJK, while thoracic shape and morphology in patients with DLS remain understudied.

Interface slip of steel-concrete composite beams reinforced with CFRP sheet under creep effect.

Under the creep action of composite steel and concrete beams reinforced by carbon-fiber-reinforced polymer (CFRP) sheet, the face of the CFRP sheet, steel beam, and concrete slab beam produce relative slip. This slip affects the interface interaction, reduces the bearing capacity and stiffness of the members, and increases the deformation. In this paper, elastic and energy methods are used to analyze the interface forces between steel beams and concrete slabs reinforced by CFRP sheeting under the action of concrete creep.

Axial Compression Property Test of GFRP Tube-Confined Coal Gangue Steel Fiber Short Concrete Column.

In order to study the axial compression property of a GFRP (glass fiber-reinforced polymer) tube-confined coal gangue steel fiber short concrete column, a test was carried out. The whole process of deformation and failure of the specimen under axial compression load was observed, and the whole process of the stress-strain curve of the specimen was obtained. The results show that the thickness of the GFRP tube has the most significant effect on the mechanical properties.

Effective length correction factor of disc-buckle type scaffolding by considering joint bending stiffness and geometrical size.

Based on the theory of sway frame column, the equation of the effective length factor was derived in this paper. Combined with the characteristics of semi-rigid joints, the linear stiffness correction factor of horizontal bar was introduced, and the equation of effective length correction factor was obtained. By using MATLAB programming method, the three-dimensional relationship between the effective length correction factor and the influencing factors was obtained, and the entire process of the stability bearing capacity of the disc-buckle type high support system was described in detail, which improves the stability calculation theory of the high support system.

Combined HTR1A/1B methylation and human functional connectome to recognize patients with MDD.

Objectives: This study aimed to use a machine-learning method to identify HTR1A/1B methylation and resting-state functional connectivity (rsFC) related to the diagnosis of MDD, then try to build classification models for MDD diagnosis based on the identified features.

Methods: Peripheral blood samples were collected from all recruited participants, and part of the participants underwent the resting-state fMRI scan. Features including HTR1A/1B methylation and rsFC were calculated.

A Predictive Model of Risk Factors for Conversion From Major Depressive Disorder to Bipolar Disorder Based on Clinical Characteristics and Circadian Rhythm Gene Polymorphisms.

Background: Bipolar disorder (BD) is easy to be misdiagnosed as major depressive disorder (MDD), which may contribute to a delay in treatment and affect prognosis. Circadian rhythm dysfunction is significantly associated with conversion from MDD to BD. So far, there has been no study that has revealed a relationship between circadian rhythm gene polymorphism and MDD-to-BD conversion.

Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response.

Background: Most antidepressants have been developed on the basis of the monoamine deficiency hypothesis of depression, in which neuronal serotonin (5-HT) plays a key role. 5-HT biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (TPH2). TPH2 methylation is correlated with antidepressant effects.

Combination of spontaneous regional brain activity and HTR1A/1B DNA methylation to predict early responses to antidepressant treatments in MDD.

Background: Antidepressant medications are suggested as the first-line treatment in patients with major depressive disorder (MDD). However, the drug therapy outcomes vary from person to person. The functional activity of the brain and DNA methylation levels correlate with the antidepressant efficacy.

The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy.

Aims: Antidepressants are effective in the treatment of major depressive disorder (MDD), while many patients fail to respond to antidepressants. Both 5-HT1A (HTR1A) and 5-HT1B (HTR1B) receptors play an important role in antidepressant activity. Meanwhile, DNA methylation is associated with MDD and antidepressant efficacy.

The relationship of tryptophan hydroxylase-2 methylation to early-life stress and its impact on short-term antidepressant treatment response.

Introduction: The gene tryptophan hydroxylase 2 (TPH2) encodes the associated rate-limiting enzyme in the biosynthesis 5-HT (serotonin). Early life stress and adult variability in TPH2 can correspond with diminished response to antidepressants for patients with major depressive disorder (MDD). DNA methylation is an epigenetic mechanism mediating gene expression, often tempered by environmental factors.

Sequential adaptive variables and subject selection for GEE methods.

Modeling correlated or highly stratified multiple-response data is a common data analysis task in many applications, such as those in large epidemiological studies or multisite cohort studies. The generalized estimating equations method is a popular statistical method used to analyze these kinds of data, because it can manage many types of unmeasured dependence among outcomes. Collecting large amounts of highly stratified or correlated response data is time-consuming; thus, the use of a more aggressive sampling strategy that can accelerate this process-such as the active-learning methods found in the machine-learning literature-will always be beneficial.

Positron imaging for verification of irradiation field during radiotherapy.

Aim Of Study: The present study was designed to investigate the application of positron images from photonuclear reactions to verify the location of targeted radiation in vivo.

Materials And Methods: The phantom study was conducted with distilled water, porcine muscle, porcine adipose tissue, and graphite; these subjects were irradiated separately with 50 MV photons generated by an MM50 Racetrack Microtron. The positron emission activity was measured using a Geiger counter, and the radioactive decay curves for each of the irradiated materials were then established.

Mixing of collinear plane wave pulses in elastic solids with quadratic nonlinearity.

This paper derives a set of necessary and sufficient conditions for generating resonant waves by two propagating time-harmonic plane waves. It is shown that in collinear mixing, a resonant wave can be generated either by a pair of longitudinal waves, in which case the resonant mixing wave is also a longitudinal wave, or by a pair of longitudinal and transverse waves, in which case the resonant wave is a transverse wave. In addition, the paper obtains closed-form analytical solutions to the resonant waves generated by two collinearly propagating sinusoidal pulses.