Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis.

Objectives: To characterize individual participant level response distributions to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration from 1979 to 2016.

Design: Individual participant data analysis.

Population: 232 randomized, double blind, placebo controlled trials of drug monotherapy for major depressive disorder submitted by drug developers to the FDA between 1979 and 2016, comprising 73 388 adult and child participants meeting the inclusion criteria for efficacy studies on antidepressants.

Attraction Versus Action in Pedophilic Desire: The Role of Personality Traits and Childhood Experience.

Objective: Comparison of pedophilic individuals who do and do not refrain from sexually engaging with children may offer critically important information regarding the differential contributors to pedophilic attraction versus behavior. This study compared 5 traits that are potentially contributory to pedophilic attraction or behavior in both minor-attracted persons (MAPs) who refrain from sexually engaging with minors (nonacting MAPs) and those who have acted on pedophilic attractions and subsequently entered the criminal justice system (forensic MAPs).

Methods: Subjects included 195 nonacting MAPs, 50 forensic MAPs, and 60 healthy controls.

Qualitative Analysis of Attitudes Toward Adult-Child Sexual Activity Among Minor-Attracted Persons.

This study uses qualitative methodology to explore narrative responses to a question regarding the harmful versus beneficial effects of adult-child sex on children. Data were gathered from a survey of self-identified minor-attracted persons (MAPs). Two hundred and sixty-seven survey participants provided narrative responses.

Comparison of Self-Identified Minor-Attracted Persons Who Have and Have Not Successfully Refrained From Sexual Activity With Children.

The present study compares community-based minor-attracted persons (MAPs) with and without histories of sexual activity with children. MAP actors (N = 342) were significantly older than non-actors (N = 223), with longer duration of pedophilic attraction, more antisocial traits, greater attraction to boys, greater difficulty controlling their attraction, and more positive attitudes toward adult-child sexual activity. Additionally, more MAP actors reported prior mental health treatment, nonsexual offenses, and childhood sexual and nonsexual abuse.

Maladaptive interpersonal schemas as sensitive and specific markers of borderline personality disorder among psychiatric inpatients.

Diagnostic criteria for borderline personality disorder (BPD) and mood and psychotic disorders characterized by major mood episodes (i.e., major depressive, bipolar and schizoaffective disorder) share marked overlap in symptom presentation, complicating differential diagnosis.