Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia.

Microglia-mediated neuroinflammatory responses have a critical function in the spinal cord injury (SCI) mechanism, and targeted modulation of microglia activity has emerged as a new therapeutic strategy for SCI. Heme oxygenase 1(HO-1) regulates the close dynamic crosstalk between oxidative stress and inflammatory responses. This investigation aimed to study the molecular pathways by which HO-1 regulates the inflammatory response of microglia.

Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia.

Spinal cord injury (SCI) is a severe central nervous system disorder with no currently available effective treatment. Microglia are immune cells in the central nervous system that play crucial roles in the SCI occurrence, development, and recovery stages. They exhibit dynamic polarization over time and can switch between classical activation (M1) and alternative activation (M2) phenotypes to respond to environmental stimuli.

Calycosin activates Nrf2/Keap1 signaling to ameliorate hydrogen peroxide-induced spinal cord neuron death and mitochondrial dysfunction.

Oxidative stress is a hallmark of secondary injury of spinal cord injuries. Controlling oxidative stress is crucial for mitigating secondary injury and promoting functional recovery after spinal cord injuries. Calycosin is an O-methylated isoflavone with antioxidant activity.

Study on Adsorption Characteristics and Water Retention Properties of Attapulgite-Sodium Polyacrylate and Polyacrylamide to Trace Metal Cadmium Ion.

The adsorption mechanism of superabsorbent polymer (SAP) can provide theoretical guidance for their practical applications in different environments. However, there has been limited research on the mechanism of attapulgite-sodium polyacrylate. This research aimed to compare the Cd(II) adsorption characteristics and water retention properties of organic-inorganic composite SAP (attapulgite-sodium polyacrylate, OSAP) and organic SAP (polyacrylamide, JSAP).

Automatic Monitoring Alarm Method of Dammed Lake Based on Hybrid Segmentation Algorithm.

Mountainous regions are prone to dammed lake disasters due to their rough topography, scant vegetation, and high summer rainfall. By measuring water level variation, monitoring systems can detect dammed lake events when mudslides block rivers or boost water level. Therefore, an automatic monitoring alarm method based on a hybrid segmentation algorithm is proposed.

A Three-Dimensional Inversion Method for Small-Scale Magnetic Objects Based on Normalized Magnetic Source Strength.

The exploration of some dangerous or important small-scale magnetic objects requires accurate three-dimensional inversion results. In this paper, a three-dimensional inversion method for small-scale magnetic objects is proposed. Normalized magnetic source strength, which is weakly sensitive to the magnetization direction, is used for inversion, which avoids the influence of the remanence of magnetic objects.

A Small Target Localization Method Based on the Magnetic Gradient Tensor.

Currently, many small target localization methods based on a magnetic gradient tensor have problems, such as complex solution processes, poor stability, and multiple solutions. This paper proposes an optimization method based on the Euler deconvolution localization method to solve these problems. In a simulation, the Euler deconvolution method, an improved method of the Euler deconvolution method and our proposed method are analyzed under noise conditions.

Effects of Nanofibers Orientation and Aspect Ratio on Dielectric Properties of Nanocomposites: A Phase-Field Simulation.

Polymer-based dielectrics with high energy storage density are attracting increasing attention due to their wide applications in pulsed-discharge and power conditioning electronic fields. Despite some numerical simulation about effects of horizontally arranged and vertically arranged fibers on dielectric properties of composites already studied, the influence mechanism of the specific orientation and aspect ratio still remains to be studied. In this work, the effects of orientation angles and aspect ratios of nanofiber fillers on breakdown behavior and dielectric properties of composites are theoretically analyzed by the finite element and phase-field method.

Multiphase Engineered BNT-Based Ceramics with Simultaneous High Polarization and Superior Breakdown Strength for Energy Storage Applications.

Dielectric ceramics are crucial for high-temperature, pulse-power energy storage applications. However, the mutual restriction between the polarization and breakdown strength has been a significant challenge. Here, multiphase engineering controlled by the two-step sintering heating rate is adopted to simultaneously obtain a high polarization and breakdown strength in 0.

Phase-field modeling of the coupled domain structure and dielectric breakdown evolution in a ferroelectric single crystal.

The study of domain switching and dielectric breakdown behavior of ferroelectrics together with their relations is crucial for understanding the essence of ferroelectric physics and exploring their applications. In this work, a phase-field method is developed to reveal the coupled domain structure and dielectric breakdown evolution in a ferroelectric single crystal (FSC) by employing the Ginzburg-Landau kinetic equation and Griffith type energy criterion. Results show that the domain switching mobility, symbolizing the speed of polarization evolution, has a significant influence on ferroelectric properties, namely coercive field, dielectric breakdown strength (DBS), discharge energy density (DED), and energy storage efficiency (ESE).