GraspDiff: Grasping Generation for Hand-Object Interaction With Multimodal Guided Diffusion.

Grasping generation holds significant importance in both robotics and AI-generated content. While pure network paradigms based on VAEs or GANs ensure diversity in outcomes, they often fall short of achieving plausibility. Additionally, although those two-step paradigms that first predict contact and then optimize distance yield plausible results, they are always known to be time-consuming.

Skeleton Extraction for Articulated Objects With the Spherical Unwrapping Profiles.

Embedding unified skeletons into unregistered scans is fundamental to finding correspondences, depicting motions, and capturing underlying structures among the articulated objects in the same category. Some existing approaches rely on laborious registration to adapt a predefined LBS model to each input, while others require the input to be set to a canonical pose, e.g.

Palbociclib and Michael-acceptor hybrid compounds as CDK4/6 covalent inhibitors: Improved potency, broad anticancer spectrum and overcoming drug resistance.

To search for potent CDK4/6 covalent inhibitors, total 14 compounds have been designed and synthesized by connecting different Michael-acceptor to the piperazine moiety of palbociclib. All the compounds displayed good antiproliferative activity against human hepatoma cell (HepG2), non-small cell lung cancer (A549), and breast cancer (MDA-MB-231 and MCF-7) cell lines. In particular, compound A4 showed the highest inhibitory activity to MDA-MB-231 and MCF-7 cells with IC values of 0.

Inhibition of oxygen dimerization by local symmetry tuning in Li-rich layered oxides for improved stability.

Li-rich layered oxide cathode materials show high capacities in lithium-ion batteries owing to the contribution of the oxygen redox reaction. However, structural accommodation of this reaction usually results in O-O dimerization, leading to oxygen release and poor electrochemical performance. In this study, we propose a new structural response mechanism inhibiting O-O dimerization for the oxygen redox reaction by tuning the local symmetry around the oxygen ions.

Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative.

Aims: CAA45 is a calothrixin A (CAA) analogue with anti-cancer activity at nanomolar concentration. This study aimed to investigate the anti-lung cancer activity of CAA45 and explore its mechanisms of actions.

Main Methods: CAA and CAA45 were synthesized and their inhibition on DNA topoisomerase I (Topo I) performed by evaluating the relaxation of supercoiled pBR322 plasmid DNA and their anti-lung cancer capacity determined by cytotoxic assays, cell migration, cell cycle, cell apoptosis, cell autophagy and related signaling proteins expression by western blot.

Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers.

We have developed a highly efficient asymmetric allylboration of ketimines with nonchiral γ,γ-disubstituted allylboronic acids by using a chiral amino alcohol as the directing group, which is otherwise challenging. The amino alcohol not only serves as a cheap source of nitrogen and chirality, but also dramatically enhances the reactivity. The versatility of this method was demonstrated by its ability to access all four stereoisomers with adjacent quaternary carbon centers.